Konjac glucomannan-liposome composite nano food delivery system and preparation method and application thereof

A technology of konjac glucomannan and delivery system, which is applied in food science and other fields, and can solve the problems of poor stability of the carrier system and difficulty in co-loading food functional factors.

Active Publication Date: 2018-09-28
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The first purpose of the present invention is to provide a kind o...

Method used

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  • Konjac glucomannan-liposome composite nano food delivery system and preparation method and application thereof
  • Konjac glucomannan-liposome composite nano food delivery system and preparation method and application thereof
  • Konjac glucomannan-liposome composite nano food delivery system and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] 1) Weigh 1 gram of KGM and disperse it in 500 mL of double distilled water, mechanically stir and swell for 12 hours at room temperature; obtain KGM1 dispersion;

[0095] 2) Weigh 0.4 g of sodium periodate and dissolve it in 20 mL of double-distilled water, add it dropwise to KGM dispersion 1, stir and react at room temperature in the dark for 48 hours; concentrate the reaction solution at 40°C to 100 mL under reduced pressure, filter, and use 3500 MW for dialysis The bag was dialyzed in double distilled water for 7 days, and then the dialysate was freeze-dried for 48 hours to obtain white DAK1 powder.

Embodiment 2

[0097] 1) Weigh 1 gram of KGM and disperse it in 500 mL of double-distilled water, mechanically stir and swell for 12 hours at room temperature to obtain a KGM2 dispersion;

[0098] 2) Weigh 0.6 g of sodium periodate and dissolve it in 30 mL of double-distilled water, add it dropwise into KGM dispersion 2, and stir for 36 hours at room temperature in the dark. The reaction solution was concentrated under reduced pressure at 45°C to 100 mL, filtered, dialyzed in double distilled water for 7 days using a 3500 MW dialysis bag, and then the dialysate was freeze-dried for 48 hours to obtain white DAK2 powder.

Embodiment 3

[0100] 1) Weigh 1 gram of KGM and disperse it in 500 mL of double-distilled water, mechanically stir and swell for 12 hours at room temperature to obtain a KGM3 dispersion;

[0101] 2) Weigh 0.8 g of sodium periodate and dissolve it in 40 mL of double-distilled water, add it dropwise into KGM dispersion 3, and stir for 24 hours at room temperature in the dark. The reaction solution was concentrated under reduced pressure at 50°C to 100 mL, filtered, dialyzed in double distilled water for 7 days using a 3500 MW dialysis bag, and then the dialysate was freeze-dried for 48 hours to obtain white DAK3 powder.

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Abstract

The invention discloses a konjac glucomannan-liposome composite nano food delivery system and a preparation method and an application thereof, which belong to the technical fields of a biomaterial andslow release. According to the invention, reduced alicyclic amine-grafted konjac glucomannan, cholesterol, egg yolk lecithin and food functional factors are subjected to composite assembly to the nano food delivery system through an ethanol injection method and a film hydration method. The special amphipathicity of system provides simultaneous loading of a plurality of hydrophilic and hydrophobiccomponents, realizes collaborative loading, protection, activity promoting and solubilization of a plurality of food functional factors, can obviously increase the physical and chemical stability andbioavailability, and endows the colon positioning performance and passive targeting. The product has the advantages of good biological compatibility and high entrapment rate, realizes positioning controlled release, stability augmentation and synergy for a plurality of food components, the preparation method is simple, and the method has wide application prospect in the fields of food functionalfactor delivery and synergism.

Description

technical field [0001] The invention relates to the technical field of biological materials and controlled release, in particular to a konjac glucomannan-liposome composite nano-food delivery system and its preparation method and application. Background technique [0002] The pressure of the working society brought about by the rapid development of today's social economy has led to an increasing number of sub-healthy populations, aging populations, and malnourished young people around the world. Therefore, nutrition, health, and safety have become the subjects of food development (Appetite, 2008, 51(3):456-67). However, functional food factors (FFC), mainly active polysaccharides, active peptides and proteins, active lipids, alcohols, vitamins, minerals, plant active ingredients, etc., exist in the process of food processing and storage. Sensitive to light, oxygen, temperature, moisture, acid and alkali, etc., easy to deteriorate, inactivate, and volatile (Food research int...

Claims

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Application Information

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IPC IPC(8): A23L29/00
CPCA23L29/03A23L29/04
Inventor 匡映姜发堂栾金玲倪学文吴考肖满
Owner HUBEI UNIV OF TECH
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