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A nano liposome preparation of snake oil and preparation process thereof

A nano-liposome and nano-lipid technology, which is applied in skin care preparations, cosmetic preparations, dressing preparations, etc., can solve problems such as precipitation, leakage, and turbid appearance of preparations

Inactive Publication Date: 2006-12-13
苏州国纳生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Otherwise, it will not be possible to achieve the technical index requirements of particle size nanometerization and stable storage for more than one year, and adverse phenomena such as snake oil liposome particle fusion, flocculation, and precipitation will occur, and the appearance of the preparation will show turbidity, sedimentation, and snake oil leakage, etc. bad quality problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] According to 1000ml unit, the prescription is as follows:

[0023] Prescription one:

[0024] Snake Oil 50ml

[0025] Egg yolk lecithin (phospholipid purity 92%) 15.0g

[0026] Cholesterol (pharmaceutical grade) 5.0g

[0027] Tween 80 (chemically pure) 50ml

[0028] a-tocopherol (vitamin E, chemically pure) 0.5g

[0029] Glycerol (analytical pure) 25ml

[0030] Ethanol (analytical pure) 20ml

[0031] Add 10g / L polyvinylpyrrolidone aqueous solution to 1000ml

[0032] Preparation process parameters: Nitrogen flow throughout the whole process, the whole process control temperature is 70°C; high-speed homogenization process parameters: rotation speed 16000 rpm, homogenization time 10min; process control parameters in the high-pressure homogenization stage: working pressure 120MPa, cycle treatment times: 6 times.

[0033] Preparation sample appearance: clear transparent liquid.

[0034] Particle size detection method: dynamic laser light scattering method. Detectio...

Embodiment 2

[0037] According to 1000ml unit, the prescription is as follows:

[0038] Prescription two:

[0039] Snake Oil 80ml

[0040] Soybean yellow lecithin (phospholipid purity 92%) 20.0g

[0041] Cholesterol (pharmaceutical grade) 2.0g

[0042] a-tocopherol (vitamin E) 1.0g

[0043] Glycerol (analytical pure) 25ml

[0044] Ethanol (analytical pure) 10ml

[0045] Xanthan Gum 150g

[0046] Add 20g / L poloxamer 188 resin aqueous solution to 1000ml

[0047] Preparation process parameters: Nitrogen flow throughout the whole process, the whole process control temperature is 75°C; high-speed homogenization process parameters: rotation speed 12000 rpm, homogenization time 15min; process control parameters in the high-pressure homogenization stage: working pressure 100MPa, cycle treatment times: 9 times.

[0048] Preparation sample appearance: clear transparent liquid.

[0049] Particle size detection method: dynamic laser light scattering method. Detection instrument: ZetaPALS type...

Embodiment 3

[0052] According to 1000ml unit, the prescription is as follows:

[0053] Prescription three:

[0054] Snake Oil 30ml

[0055] Egg yolk lecithin (phospholipid purity 92%) 5.0g

[0056] Cholesterol (pharmaceutical grade) 1.0g

[0057] Tween 80 (chemically pure) 50ml

[0058] a-tocopherol (vitamin E, chemically pure) 0.52g

[0059] Glycerol (analytical pure) 20ml

[0060]Ethanol (analytical pure) 5ml

[0061] Add 20g / L polyvinylpyrrolidone aqueous solution to 1000ml

[0062] Preparation process parameters: Nitrogen flow throughout the whole process, the whole process control temperature is 65°C; high-speed homogenization process parameters: speed 6000 rpm, homogenization time 10min; process control parameters for high-pressure homogenization stage: working pressure 120MPa, number of cycles is 3 times.

[0063] Preparation sample appearance: clear transparent liquid.

[0064] Particle size detection method: dynamic laser light scattering method. Detection instrument: Ze...

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Abstract

The invention relates to a snake oil nano liposome preparation used for cosmetic products and process for preparing same, wherein the preparation is made from snake oil, phosphatidy icholine, cholesterin, anti-oxidant, solubilizing agent, thickening agent and glycerin as isotonic agent through the steps of proportioning raw materials according to formulation quantity, preparing oily phase and aqueous phase, mixing the oily phase and aqueous phase, venting nitrogen at 60-85 deg. C to obtain coarse dispersible article, then carrying out high pressure homogenization circulating treatment at 60-150MPa till transparency, finally cooling naturally.

Description

technical field [0001] The invention relates to a prescription of snake oil nano liposome preparation used in cosmetics and a preparation process thereof, belonging to the field of hygienic cosmetics. Background technique [0002] Snake oil is a common cosmetic raw material with clear efficacy, nourishing and caring for the skin, and it is widely used at home and abroad. In the current preparation of snake oil cosmetics, the snake oil is simply dispersed and mixed in the excipient matrix for use. Since the active ingredient of the snake oil extract is a macromolecular protein, it is difficult for it to penetrate the stratum corneum barrier of the skin and enter the deep layer of the skin to play a good role. effect. In recent years, with the development of nanoscience and technology, studies have found that nano-drug loading technology can carry drugs well to solve problems such as epidermal barrier, intestinal wall barrier, and brain-blood barrier, so that drugs can better...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61K8/14A61Q19/00
Inventor 张小宁郝艳丽韩伟卢永凯梁言慈
Owner 苏州国纳生物技术有限公司
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