Essential oil liposome as well as preparation method and application thereof

A technology of oily liposomes and orange red essential oil, which is applied in the chemical industry, can solve the problems of volatile essential oils, oral mucosa irritation, and low solubility, and achieve good anti-inflammatory effects, good stability, and good experience

Active Publication Date: 2020-12-29
GUANGZHOU XIANGXUE PHARMA CO LTD
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the following problems mainly exist in the preparation of the orange red essential oil product: 1) the main component of the orange red essential oil—limonene is easy to oxidize and deteriorate, and the essential oil is volatile, resulting in unstable product quality; 2) the solubility of the essential oil in water is very low, and many essential oil oral sprays, Essential oil mouthwash and other products usually use ethanol to help dissolve, but ethanol is irritating to the oral mucosa, and mild mouth spray and mouthwash without ethanol are limited by solubility, and the amount of essential oil added is very small, often not reaching the desired level. desired effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Essential oil liposome as well as preparation method and application thereof
  • Essential oil liposome as well as preparation method and application thereof
  • Essential oil liposome as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0061] The present invention also provides the preparation method of above-mentioned essential oil liposome, comprises the following steps:

[0062] ① Mix the phospholipids, cholesterol, emulsifier and water and homogenize to prepare mixture A;

[0063] ② Mix the mixture A with the citrus red essential oil, homogenize, and prepare the mixture B;

[0064] ③ Cool down the mixture B to below -15°C, keep warm, heat up, and homogenize;

[0065] ④ Repeat step ③ 1 to 2 times.

[0066] The inventor also found after paying a large amount of creative work that step 1., 2. and 3. the size of the shear velocity and the size of the pressure during homogenization all have a greater impact on the particle diameter of the essential oil liposome, and further affect the liposome. plastid stability. Specifically, if the shear velocity is too large or the pressure is too high, the liposome particle size is too small, less than 150nm, its surface tension is large, fusion is easy to occur, and t...

Embodiment 1

[0109] This embodiment provides an essential oil liposome and its preparation method and application.

[0110] (1) The composition of essential oil liposome:

[0111] 100 parts of egg yolk lecithin, 6 parts of cholesterol, 5 parts of orange essential oil, 5 parts of Span-60, 200 parts of water.

[0112] (2) Preparation of essential oil liposome:

[0113] ① Take egg yolk lecithin, cholesterol, Span-60 and water in the above composition ratio, and shear and homogenize at a speed of 10000r / min under the condition of 50°C, and homogenize under a pressure of 120MPa under high pressure, so that the mixture is evenly dispersed;

[0114] ②Then add the citronella essential oil at 50°C, shear and homogenize at a speed of 10,000r / min, and homogenize under a pressure of 120MPa to obtain an essential oil mixture;

[0115] ③Quickly cool down the essential oil mixture to -15°C, keep it for 30 hours, heat up to 35°C, shear and homogenize at a speed of 10,000r / min, and homogenize under a pre...

Embodiment 2

[0122]This embodiment provides an essential oil liposome and its preparation method and application.

[0123] (1) The composition of essential oil liposome:

[0124] 100 parts of soybean lecithin, 20 parts of cholesterol, 15 parts of orange essential oil, 25 parts of Span-80,

[0125] 400 parts of water.

[0126] (2) Preparation of essential oil liposome:

[0127] ①Take soybean lecithin, cholesterol, Span-80 and water in the above composition ratio, and shear and homogenize at a speed of 20,000r / min under the condition of 55°C, and homogenize under a pressure of 80MPa under high pressure to disperse the mixture evenly;

[0128] ②Add the essential oil of orange red at 55°C, shear and homogenize at a speed of 20,000r / min, and homogenize under a pressure of 80MPa to obtain an essential oil mixture;

[0129] ③Quickly cool down the essential oil mixture to -25°C, keep it for 15 hours, heat up to 50°C, shear and homogenize at a speed of 20,000r / min, and homogenize under a high pr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to an essential oil liposome as well as a preparation method and application thereof. The essential oil liposome is prepared from the following materials in parts by weight: 100parts of phospholipid, 3-25 parts of cholesterol, 3-20 parts of pummelo exocarp essential oil, 3-30 parts of emulsifier and 100-500 parts of water. The phospholipid is selected from at least one of the soybean lecithin and the egg yolk lecithin; and the emulsifier is selected from at least one of the span, the tween, the propylene glycol and the glycerol. It can effectively improve stability of the essential oil and has a slow-release performance. In addition, the essential oil liposome has the functions of reducing phlegm, relieving cough, anti-inflammatory and the like, and has a fragrant smell, mild and low irritation. When being used for preparing an essential oil liposome product, it has good effects in reducing phlegm, relieving cough and anti-inflammatory, also has good stability and good experience.

Description

technical field [0001] The invention belongs to the technical field of chemical industry, and in particular relates to an essential oil liposome and its preparation method and application. Background technique [0002] Huajuhong is the dried young fruit, immature or near-ripe dry outer pericarp of Citrus grandis 'Tomentosa' of the Rutaceae plant; or the immature or near-ripe dry outer pericarp of Citrus grandis (L.) Osbeck . It has the effects of regulating qi and widening the middle, drying dampness and resolving phlegm. Modern pharmacological studies have shown that the essential oil contained in Huajuhong has the effects of reducing phlegm, relieving cough, and anti-inflammatory, and has an aromatic smell. [0003] Applying orange red essential oil to oral care products can effectively relieve bad breath, sticky mouth, oral inflammation and other problems, and can also freshen breath. But the following problems mainly exist in the preparation of the orange red essentia...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K47/24A61K47/28A61K36/752A61P1/02A61P11/10A61P11/14A61P29/00
CPCA61K9/127A61K47/24A61K47/28A61K36/752A61P1/02A61P11/10A61P11/14A61P29/00
Inventor 王艳慧杨丽莹黄洁文黄绮韵吴舒楹秦群英
Owner GUANGZHOU XIANGXUE PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap