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Injection containing nervonic acid and phospholipid compound as well as preparation method and application of injection

A technology of nervous acid and water for injection, which is applied in the field of medicine, can solve the problem of not finding the compound composition of phospholipid and nervous acid

Active Publication Date: 2015-04-22
哈尔滨医大药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Neural acid or phospholipids have been processed into various health foods, such as soft capsules, tablets, etc., but no compound composition of phospholipids and phospholipids has been found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136] Embodiment 1, lecithin nervonic acid fat emulsion injection and preparation method thereof

[0137] The prescription quantity is calculated by weight percentage and contains:

[0138] Lecithin 1% to 5%, preferably 1.5%,

[0139] Nervous acid 0.03%~1.5%, preferably 0.1%,

[0140] Add water for injection to 100%;

[0141] Preparation: (1) Ingredients: Weigh lecithin and nervonic acid according to the formula, add them to water for injection, set the volume to the required production volume, stir, mix and disperse evenly;

[0142] (2) Emulsification: Put the liquid prepared in (1) in the emulsification tank, and continuously feed 20-30L / min nitrogen or carbon dioxide from the bottom of the emulsification tank, when the liquid temperature is 65-80°C and the stirring speed is greater than 2500r Under the condition of 1 / min, carry out the emulsification operation for 10-20 minutes, and then pass through the interlayer cooling water to cool the injection solution to 25°C wi...

Embodiment 2

[0147] Embodiment 2, Yuanbao Maple Seed Oil Neural Acid Fat Emulsion Injection and Preparation Method thereof

[0148] The prescription quantity is calculated by weight percentage and contains:

[0149] Lecithin 1% to 10%, preferably 2%,

[0150] Ingot maple seed oil (neuric acid content ≥ 4.0%) 0.05% to 2%, preferably 0.15% (based on nervous acid content),

[0151] Add water for injection to 100%;

[0152] Preparation: degumming, deacidification, decolorization, adsorption, deodorization, filtration and high temperature sterilization of ingot maple seed oil in advance, so that the color, acid value, peroxide value, unsaponifiable matter and moisture content meet the quality standards of pharmacopoeia refined vegetable oil , and the nervonic acid content ≥ 4.0%, the refined ingot maple seed oil is used in this embodiment as a nervonic acid donor;

[0153] (1) Ingredients: Weigh lecithin and ingot maple seed oil according to the formula, add them to water for injection, set ...

Embodiment 3

[0159] Embodiment 3, nervonic acid fat emulsion injection and preparation method thereof

[0160] The prescription quantity is calculated by weight percentage and contains:

[0161] Lecithin 0.5%~5%, preferably 1.2%,

[0162] Nervous acid 0.03%~1.5%, preferably 0.2%,

[0163] Soybean oil 3%~15%, preferably 10%,

[0164] Add water for injection to 100%;

[0165] Preparation: degumming, deacidification, decolorization, adsorption, deodorization, filtration and high-temperature sterilization of soybean oil in advance, so that the color, acid value, peroxide value, unsaponifiable matter and moisture content meet the quality standards of refined vegetable oil in the Pharmacopoeia, or Soybean oil of commercially available drug injection grade is used in this embodiment;

[0166] (1) Ingredients: Weigh lecithin, nervous acid, and soybean oil according to the formula, first dissolve nervonic acid in soybean oil completely, then add lecithin into water for injection, set the volume...

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Abstract

The invention provides a fat milk injection containing phospholipid, nervonic acid and water for injection. In the injection, the content of the water for injection is larger than 70% in weight ratio; the particle size of fat globules in the injection is smaller than 1 micrometer; the phospholipid comprises lecithin, phosphatidyl ethanolamine and phosphatidyl inositol, wherein the phospholipid and the nervonic acid are combined by a weight ratio of 1:(0.005-1). The invention also provides a preparation method of the fat milk injection and application of the fat milk injection in injection and replenishment of the nervonic acid, the phospholipid, unsaturated fatty acid and medicines for preventing and treating diseases such as cranial nerve degenerative changes, cerebral injuries and disordered brain function.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to injection medicine containing nervonic acid and phospholipid compound, as well as its preparation method and application. Background technique [0002] Neural acid, cis-15-tetradecenoic acid, is a long-chain monounsaturated fatty acid, which is an important component of biological membranes in nervous tissue, a symbolic component of cerebroside medulla, cranial nerve fibers and nerve The core natural component of cells is also an essential nutrient for the growth, regeneration and function maintenance of nerve cells, especially brain cells, optic nerve cells, and peripheral nerves. It mainly exists in human brain tissue in the form of glycosphingolipids and sphingomyelin. It plays an important role in the biosynthesis of the sheath, and plays an important role in regulating information transmission and information processing through ion channels and receptors on the nerve cell m...

Claims

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Application Information

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IPC IPC(8): A61K31/685A61K31/683A61K9/107A61P3/02A61P25/00A61P25/28A61P9/00A61P9/10A61P3/06A61P9/12A61P1/16A61K31/201
CPCA61K9/0019A61K9/107A61K31/201A61K31/683A61K31/685A61K2300/00
Inventor 张耿元王保红白东跃唐湘成俞世宏
Owner 哈尔滨医大药业股份有限公司
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