41 results about "Phosphatidyl serine" patented technology

The invention relates to an oral drug delivery system which delivers biologically active substances to the mucosal tissue of the intestine utilizing novel polymerized liposomes. Novel polymerizable fatty acids having a polymerizable group, a surfactant group, and a functional group, and optionally coupled to ligands which target mucosal tissue in the intestine are disclosed. Novel negatively charged polymerizable lipids which have phosphatidyl inositol (PI), phosphatidyl glycerol (PG) or phosphatidyl serine (PS) groups on a polymerizable backbone are also described.

The invention relates to an oral drug delivery system which delivers biologically active substances to the mucosal tissue of the intestine utilizing novel polymerized liposomes. Novel polymerizable fatty acids having a polymerizable group, a surfactant group, and a functional group, and optionally coupled to ligands which target mucosal tissue in the intestine are disclosed. Novel negatively charged polymerizable lipids which have phosphatidyl inositol (PI), phosphatidyl glycerol (PG) or phosphatidyl serine (PS) groups on a polymerizable backbone are also described.

The present invention provides formulas for producing compositions for the structural / functional nutritional support for those who struggle with poor focus, concentration and / or memory. In addition, the present invention provides compositions comprising nutritional / botanical factors helpful to those who subjectively experience transient mental fatigue or poor cognitive function. The compositions of this invention consist primarily of the following ingredients B-complex vitamins, antioxidants, minerals, phosphatidyl serine (PS), choline, dimenthyl-aminoethanol (DMAE), docosahexaenoic acid (DHA), L-pyroglutamic acid, as well as herbal extracts from Bacopa monniera, Vinca minor, and Huperzia serrata. The present invention also relates to the administration of these compounds to alleviate mental fatigue or poor cognitive function.

The invention relates to a polyamine micromolecular compound, comprising the following structures described in the specification, wherein M<x+> is 0, Zn<2+>, Ga<3+>, Gd<3+>, Ca<2+> or other divalent metal ions and trivalent metal ions; S is a reporter group (including a nuclide labeling prothetic group, a paramagnet, a fluorescein or a microvesicle), such as the nuclide labeling prothetic group: -<11>CH3, -CH2CH2<18>F, -CH2CH2(OCH2CH2)2NHCOC6H4<18>F-p or -CH2CH2(OCH2CH2)2NH-CH2CH2<18>F; R is -H, -OCH3, -OCH2CH3 or -Cl; and R1, R2, R3 and R4 are hydrogen, carboxyl, alkane, alkylene or heteroalkyl. The invention further relates to application of the compound in preparing cell death or apoptosis developers of target phosphatidyl serine (PS) and / or apoptotic cell early free Zn<2+>. The compound provided by the invention is a specific multiamine micromolecular developer for target phosphatidyl serine (PS) and / or apoptotic cell early free Zn<2+>, which can be used for monitoring curative effects of PS-related anti-tumor chemotherapy, radiotherapy, biological therapy and the like; the compound can be used for early differential diagnosis of neurodegenerative diseases (senile dementia and Parkinson's disease), cerebral apoplexy, AIDS (Acquired immune deficiency syndrome), thrombus, atheromatous plaque and myocardial infarction; and the compound can also be used for differential diagnosis and curative effect monitoring of other diseases related to PS expression in the cell death or apoptosis process, such as inflammation development and anti-inflammation therapeutic development.

The invention discloses an intelligence developmental brain tonic hygienic soft capsule and preparing method, which comprises the following parts: calico salmon carrier extract oil (1-5)%, condensed deep-marine fish oil (50-65)%, walnut oil (15-25) %, perilla oil (5-20)%, phosphatidyl serine (1-5)% and vitamin E (0.1-0.2)%. The manufacturing method comprises the following steps: (1) preparing calico salmon carrier extract oil, (2) allocating, (3) metering filled soft capsule.

A food item, preferably a bar of chocolate, that has a phosphatidyl serine content of 100 mg to 300 mg and a relatively high carbohydrate content.

Synthetic and semisythetic bodies having a three-dimensional structure, sized and shaped to resemble apoptotic cells and apoptotic bodies, and having phosphatidyl serine (PS) molecules on the surface thereof, are administered to a patient, to alleviate a variety of disorders such as T-cell mediated disorders (autoimmune conditions). The bodies are believed to trigger and apoptosis-like mechanism in the patient.

The invention relates to a technique for preparing diacylglyceryl-phosphorylserine rich in unsaturated acid, which is characterized in that a reactor is preheated to 30 to 60 DEG C, squid lecithin and L-serine at the mass ratio of 1:1-15 is added, phosphatidase D2-15U / g is also added as reaction substrate, gas R134a is pumped to lead the pressure of the reactor to reach 4-6MPa, the pressure is reduced after agitating reaction for 2 to 8 hours, R134a is recycled after the reaction mixture comes into a separation pot which is communicated with the reactor under the temperature of 30 to 60 DEG C, reaction mixture is collected from the a sample receiving port of the separation pot, at last, the reaction mixture is washed by using acetone and centrifuged for 5 to 10 min to separate the solid phase for further purification. The diacylglyceryl-phosphorylserine prepared by the invention rich in high unsaturated fatty acid as the medium in catalytic reaction of phosphatidase D has the advantages of simple technique, low equipment input, short reaction time, high content of unsaturated fatty acid and high yield and the neglecting of organic solvent. Furthermore, R134a can be completely recycled after reaction, which is beneficial to the separation of products and repeated use of enzyme.

Two very important factors in human life—which play vital roles in promoting well being—includes returning the body to homeostasis and giving boost to body called lifeforce to get overall health free from diseases, i.e., its optimal balanced functioning ability. When the body is at homeostasis, there is no place for disease. It is only when the body is out of balance (something is deficient, in excess or stagnating) that pain, illness or disease can occur. The application described is based on returning the body to homeostasis (removing the problem and balancing the body) by providing lifeforce and not on dealing with the symptom (e.g., pain, vitamin deficiency). Imbalance results in various diseases and adverse health conditions (starting from aging to diabetes and cancers). This wonderful composition will interact with the body in a way that allows it to boost lifeforce and reach homeostasis no matter which direction it was. In this combination, in the form of liquid, all the 14 ingredients (Lepidium meyenii (Maca), Croton planstigma (Dragon's blood) tree sap, Uncaria tomentosa (Cat's Claw), Morinda citrifolia (Noni fruit) 4:1 PE, Lutein, Lycopene 5%, Flaxseed Oil (Omega-3-Fatty Acids), Vinpocetine, Phosphatidyl Serine 50%, Korean Ginseng 80%, Bacopa monnieri (Bacopin), CDP Choline (Cognizing), Guaranine (Guarana Seed PE 12%), Yerba Mate Ext. 8%) work as mixture for returning the body to homeostasis and give it lifeforce.

Chimeric proteins comprising soluble Tissue Factor (sTF) and another subunit (e.g., annexin V) are described. The proteins promote blood clotting and / or inhibit cancer by targeting sTF to specific receptors such as phosphatidyl serine (PS) on activated cells. These chimeric proteins are useful in treating patients with excessive bleeding due to inborn problems, drug therapy, trauma or surgery and / or as an anti-cancer therapy, for example by causing blood vessels feeding cancers to become clotted, thereby preventing adequate flow of blood to a tumor, which in turn will lead to tumor inhibition and death or may be used in a therapy to cause clotting within blood vessels that pose a threat in the subject in non-cancerous conditions.

The invention discloses a health-care food composition for assisting to improve memory and a preparation method thereof. The health-care food composition contains ginkgo leaf extract, gamma-aminobutyric acid, phosphatidyl serine, 2-aminoethanesulfonic acid, zinc lactate, vitamin C and vitamin B12. The invention also discloses a preparation method of the health-care food composition. The health-care food composition has the function of assisting to improve memory.

A pharmaceutical composition for the prevention, protective effect, or treatment of a neurodegenerative condition, is provided. The composition includes a combination of cannabidiol water soluble powder; astaxanthin; alpha-glyceryl phosphoryl choline; and phosphatidyl serine. Optional supporting ingredients may be provided also.

The invention provides a nutrient composition capable of relieving pressure as well as a preparation method and application of the nutrient composition. The nutrition composition comprises the following components in parts by weight: 0.5-2 parts of vitamin C, 0.2-0.6 part of a vitamin B group, 0.1-0.5 part of vitamin E, 0.0005-0.002 part of vitamin D, 2-8 parts of magnesium, 2-8 parts of curcumin,2-8 parts of betaine, 2-10 parts of gamma-aminobutyric acid, 1-8 parts of tea leaf theanine, 30-50 parts of licorice roots, 2-10 parts of phosphatidyl serine, 2-8 parts of L-tyrosine and 15-35 partsof ginseng. The nutrient composition can relieve pressure symptoms from the respects of improving sleep, resisting weariness, resisting inflammation and the like, and supports the adrenal gland function from a nutritive layer. Relevant nutrient components can be complemented pointedly. Through cooperative promotion of functions of various nutrient components, the capacity of pressure resistance oforganisms can be strengthened, and the entire health of pressure resistance systems is realized.

The invention discloses a preparation method of phosphatidyl serine, which comprises the following steps: taking coarse soybean lecithin as a raw material, adding water-saturated butyl acetate, stirring, and performing reflux degradation; evaporating the butyl acetate under reduced pressure, adding methanol into the concentrate, and performing reflux dissolution; recovering the methanol from the methanol layer under reduced pressure, thus obtaining a methanol solvend; preparing the methanol solvend and organic solvent into a solution, then preparing the organic phase and an enzyme-containing water solution into a water phase, mixing the organic phase and the water phase, and reacting; after the reaction is finished, separating out the organic phase, washing the organic phase with water, and removing the organic solvent in vacuum; and dissolving the concentrate with anhydrous ethanol, stirring, separating out an anhydrous ethanol insoluble substance, and performing vacuum drying to obtain the phosphatidyl serine product. Compared with the prior art, the preparation method has the following advantages: (1) the used raw material is the coarse soybean lecithin, so that the phosphatidylcholine content is low, and the price is low; and (2) the whole process is simple and easy to industrialize, the content of the prepared phosphatidyl serine is 40% or above, and the purity is high. Thus, the preparation method disclosed by the invention has important meanings for phospholipid industry, health food and medicine industry in China.

The present invention relates to a method for inhibiting a disease response in a subject comprising contacting dead or dying cells exposing an antigen selected from the group consisting of a phosphorylcholine (PC) determinant, a phosphatidyl serine (PS) determinant, a MDA determinant, and cardiolipin in the subject, with an antibody or recombinant protein that recognizes and binds the antigen that is exposed on the dead or dying cells, thereby inhibiting the pathologic response in the subject.

The invention provides functional sweets capable of relieving pressure and a making method of the functional sweets. The functional sweets comprise an nutrient composition and auxiliary materials, wherein the nutrient composition consists of the following components in parts by weight: 0.5-3 parts of a vitamin mixture, 2-10 parts of magnesium, 1-15 parts of calcium, 1-10 parts of gamma-aminobutyric acid, 1-10 parts of tea leaf theanine, 20-55 parts of licorice roots, 1-15 parts of phosphatidyl serine, 1-10 parts of L-tyrosine, 10-35 parts of ginseng, 1-15 parts of curcumin, and 1-15 parts of betaine, and the auxiliary materials are selectively added according to the type of the made sweets. The functional sweets can relieve pressure symptoms from the respects of improving sleep, resistingweariness, resisting inflammation and the like. Relevant functional components can be complemented pointedly, and through associated promotion of various nutrient functional components, the capacity of resisting pressure of organisms can be strengthened. The functional sweets can be used as sweets to be suitable for various crowds, have certain health-care efficacy, and conform to green and healthy diet view of modern consumers.

The invention discloses an odor-free DHA solid beverage capable of promoting mentality and invigorating brain and a preparation method thereof. The DHA solid beverage is prepared from algal oil DHA powder, sugar powder, mango powder, lemon powder, walnut powder, phosphatidyl serine (PS), beta-cyclodextrin, ascorbic acid, anhydrous citric acid, sodium bicarbonate, carotenes, sucralose and edible essence. The preparation method comprises the following steps: double embedding of DHA, pelletizing, blending, mixing and packaging by filling of inert gas. The odor-free DHA solid beverage is characterized in that the content of the added DHA is as high as 200mg / 7g, double embedding (spray fluidized drying) of the DHA is performed, carbon dioxide CO2 and nitrogen gas N2 are mixed in the optimal ratio of 3:7, and the antioxidation effect is the best. The high-content and odor-free formula DHA solid beverage product is developed by virtue of functional characteristics of different auxiliary materials and a double DHA embedding and taste-masking process, can be drunk happily by people and achieves the effects of invigorating brain, promoting mentality and improving cardiovascular and cerebrovascular diseases; and on-line leak detection can be performing by mixed gas packaging, nitrogen-filled packaging is adopted to ensure fat oxidation of products, the nitrogen gas content in air is high,detection of nitrogen gas cannot confirm whether packages leak, and oxidation rancidity and deterioration are ensured to be prevented in 24 months. When the DHA solid beverage is brewed to be drunk,consumers can feel effervescence reaction and hear bubble churning sound, so the interestingness in drinking is improved; and the brewed DHA solid beverage has soft mouthfeel and no alkaline taste (soapy water taste) which a traditional effervescent product has, has joyful fruity flavor which makes people feel relaxed and happy and is an essential leisure drink for home and travel.

Chimeric proteins comprising soluble Tissue Factor (sTF) and another subunit (e.g., annexin V) are described. The proteins promote blood clotting and / or inhibit cancer by targeting sTF to specific receptors such as phosphatidyl serine (PS) on activated cells. These chimeric proteins are useful in treating patients with excessive bleeding due to inborn problems, drug therapy, trauma or surgery and / or as an anti-cancer therapy, for example by causing blood vessels feeding cancers to become clotted, thereby preventing adequate flow of blood to a tumor, which in turn will lead to tumor inhibition and death or may be used in a therapy to cause clotting within blood vessels that pose a threat in the subject in non-cancerous conditions.

The present invention provides medicaments for allergic diseases (atopic dermatitis, asthma, and the like), and a tool useful for pathology analysis of allergic diseases. A medicament containing as an effective component an activity modulator for suppressing inhibitory signal transduction of a CD300a-expressing myeloid cell, which activity modulator contains a substance that inhibits binding of CD300a to phosphatidyl serine, can be used for treatment or prophylaxis of an allergic disease. A CD300a gene-deficient mouse can be used as a model mouse in which the allergic disease is hardly induced after administration of a substance that induces the allergic disease, which may be used for carrying out pathology analysis of an allergic disease, or for screening of a possible candidate substance for an effective component of a therapeutic agent or prophylactic agent for the disease.

Synthetic and semisynthetic bodies having a three-dimensional structure, sized and shaped to resemble apoptotic cells and apoptotic bodies, and having phosphatidyl serine (PS) molecules on the surface thereof, are administered to a patient, to alleviate a variety of disorders such as T-cell mediated disorders (autoimmune conditions). The bodies are believed to trigger an apoptosis-like mechanism in the patient.

The invention discloses cream free of trans-fatty acid, which is prepared from the following raw materials: sunflower seed oil, walnut oil, eucommia seed oil, nutritional powder, soybean oligosaccharide, skimmed milk powder, lactobacillus bulgaricus, purple potato starch, phosphatidyl serine, soluble soybean polysaccharide, propolis and water. The cream free of trans-fatty acid, provided by the invention, is scientific in proportioning, rich in nutrient and easy to absorb, contains unsaturated fatty acid, has the fat content of lower than 30% and the trans-fatty acid content of lower than 0.3%, and is capable of promoting gastrointestinal functions, expelling toxins and beautifying the face, preventing and treating cardiovascular and cerebrovascular diseases, nourishing the brain and developing intelligence, enhancing resistance, resisting oxidation, aging and tumors and keeping the body young; the nutritional powder contains dietary fiber and vitamins and is capable of promoting gastrointestinal functions, resisting oxidation and accelerating trans-fatty acid decomposition; the extraction time of the purple potato starch is shortened by 1 / 4, and the starch extraction rate is improved by 18%, so that the cost is saved; and the shelf life of the cream at normal temperature is 90 days, so that the production cost and storage cost are obviously reduced.

The present invention provides formulas for producing compositions for the structural / functional nutritional support for those who struggle with poor focus, concentration and / or memory. In addition, the present invention provides compositions comprising nutritional / botanical factors helpful to those who subjectively experience transient mental fatigue or poor cognitive function. The compositions of this invention consist primarily of the following ingredients B-complex vitamins, antioxidants, minerals, phosphatidyl serine (PS), choline, dimenthyl-aminoethanol (DMAE), docosahexaenoic acid (DHA), L-pyroglutamic acid, as well as herbal extracts from Bacopa monniera, Vinca minor, and Huperzia serrata. The present invention also relates to the administration of these compounds to alleviate mental fatigue or poor cognitive function.

The invention relates to the technical field of veterinary albendazole preparation, in particular to an albendazole liposome and a preparation process thereof. A liposome of albendazole comprise thatfollowing component in parts by weight: 8 to 15 parts by weight of albendazole; 1- Palmitoyl group- 2- 25 to 35 part of oleoyl phosphatidyl glycerol, 6 to 15 part of dipalmitoyl phosphatidyl serine, 10 to 20 part of dierucyl phosphatidylethanolamine, 1 to 5 part of antioxidant, 2 to 6 part of additive. A liposome of albendazole and its preparation method, It can improve the solubility of albendazole, slow down drug release, increase the absorption rate of albendazole, increase the bioavailability of albendazole, increase the targeting and pertinence of the drug, and has high encapsulation efficiency and ABZ drug loading capacity. In addition, the preparation method is simple in production, easy in operation and low in cost.

The present disclosure relates to a method of targeting stems cells, in particular non-apoptotic stem cells, employing a GLA domain, capable of binding surface exposed phosphatidyl serine.

The invention provides a biosensor for a phosphatidyl serine (PS) exosome and a preparation method of the biosensor. According to the method, a PS specific recognition peptide serves as a recognitionmodule, a biosensing electrode assembled by the recognition peptide serves as a capture substrate, and an electrochemiluminescence probe formed by a g-C3N4 nanosheet, luminol-AuNPs and the recognitionpeptide serves as a signal probe. The PS exosome in the sample is specifically recognized by the capture substrate and the signal probe in order to form a sandwich structure, and a detection signal is generated through the signal probe. The PS recognition peptide can be specifically combined with the PS on the exosome of a tumor source, and the PS recognition peptide is simple in structure, highin affinity and selectivity, not prone to be influenced by environmental factors such as pH and temperature, and good in stability. According to the biosensor and the preparation method of the biosensor, high-sensitivity and high-selectivity PS exosome detection can be realized.

Provided is a composition comprising a phosphatidyl serine receptor ligand for use in immune therapy. The composition may include an antigen or allergen together with the phosphatidyl serine receptor ligand. The compositions may be used for any type of immune therapy, such as immune modulation to an environmental antigen or allergen, down regulation of immune hypersensitivity reactions, and stimulation of antigen or allergen specific IgA and / or IgG4.

The present invention relates to the technical field of production and preparation of phosphatidylserine, in particular to a method for rapidly and stably preparing phosphatidylserine for food, comprising the following steps: A, dispersing phospholipase D in an ionic liquid to obtain a mixed system; B, Add soybean lecithin and serine into the mixed system and let it stand to obtain phosphatidylserine; the present invention makes the enzyme have good catalytic activity and temperature stability through ionic liquid, adds soybean lecithin and serine to the ionic liquid, and adds emulsifying Agent, through ultrasonic treatment, phospholipase D quickly catalyzes the synthesis in ionic liquid to form phosphatidylserine, the reaction time is short and the yield is high. The product is suitable to be added to health foods such as milk and beverages, and has significant effects on preventing cognitive impairment and alleviating fatigue.

The invention discloses a preparation method of phosphatidyl serine. The preparation method comprises the following steps of (1) mixing phosphatidylchline and chloroform to prepare a mixture M1; (2) adding L-serine and water into the mixture M1 to prepare a mixture M2; (3) adding phosphatidase D into the mixture M2, thus preparing a phosphatidyl serine crude product; (4) adding chloroform into the phosphatidyl serine coarse product, mixing, and then collecting a chloroform layer; (5) concentrating the chloroform layer collected in the step (4); after the concentration, adding acetone; mixing, then performing suction filtration; taking filter cake; drying to prepare the phosphatidyl serine. The phosphatidylchline and the chloroform are firstly mixed; then, the L-serine and the water are added into the mixture; then, the phosphatidase D is added; the chloroform is added on the basis of the phosphatidyl serine coarse product, and mixing is performed; then the chloroform layer is subjected to concentration, then, concentrated materials are taken and are added into the acetone; the suction filtration is performed; drying is further performed; the high-purity phosphatidyl serine is prepared.

Synthetic and semisynthetic bodies having a three-dimensional structure, sized and shaped to resemble apoptotic cells and apoptotic bodies, and having phosphatidyl serine (PS) molecules on the surface thereof, are administered to a patient, to alleviate a variety of disorders such as T-cell mediated disorders (autoimmune conditions). The bodies are believed to trigger an apoptosis-like mechanism in the patient.

The invention discloses a preparation technology of an oral vaccine for resisting salmonella. The preparation technology comprises the following steps of constructing escherichia coli for expressing antigens of salmonella SEF14 and SEF21 fimbriaes, carrying out fimbrial antigen purification by a protein purification technology, dissolving dipalmitoyl phosphatidyl choline, dipalmitoyl phosphatidylserine and cholesterol in an organic solvent, fully mixing, drying mixed lipid, adding a certain amount of the antigens of SEF14 and SEF21 into a mixed lipid membrane, fully mixing, and carrying out lipid membrane vortex-type dispersion to obtain the oral vaccine. The preparation technology greatly improves the purity of salmonella antigens, and realizes stable, simple and controllable production having a high yield and high purity. The oral vaccine obtained by the preparation technology has effects of effectively resisting an acid environment and a damage caused by a body enzyme system. Through the preparation technology, SEF14 and SEF21 fimbriae protein antigens can be applied by an oral method. The preparation technology realizes complete detoxification and high immunogenicity and does not produce environmental pollution.