The present invention belongs to the field of
pharmaceutical technology, and relates to
docetaxel triglyceride prodrugs and their lipid preparations, as well as
docetaxel-
triglyceride prodrugs mediated by lymphatic transport and their lipid preparations and their application in the preparation of oral
chemotherapy drugs. The present invention provides a lipid preparation of
docetaxel-
triglyceride prodrug, which comprises a docetaxel-triglyceride
prodrug and excipients. The excipients include
phospholipid emulsifiers, short-chain
alcohol or
ether co-emulsifiers, and liquid oil phases. By weight percentage, the liquid
oil phase accounts for 30%-85% of the lipid preparation, the
phospholipid emulsifier accounts for 10%-45% of the lipid preparation, and the short-chain
alcohol or
ether co-emulsifier accounts for 5%-25% of the lipid preparation; the docetaxel-triglyceride
prodrug accounts for 1%-10% of the total weight of the excipients. The docetaxel-triglyceride prodrug of the present invention promotes the lymphatic transport of docetaxel, avoids the first-pass effect, and thus improves its oral absorption.