Novel flavane derivative and its preparation method and uses

A kind of derivative, flavan technology, applied in the new flavan derivative and its preparation and use field

Active Publication Date: 2006-05-03
SHANHE PHARMA GUANGZHOU CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the curative effect and quality of this product cannot be determined by the content of active ingredients

Method used

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  • Novel flavane derivative and its preparation method and uses
  • Novel flavane derivative and its preparation method and uses
  • Novel flavane derivative and its preparation method and uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Operate according to the process flow diagram shown in accompanying drawing 1, 70g dried monkey earring leaves are crushed in a blender, extracted twice with 350ml of 95% ethanol solution under reflux, filtered, and the combined filtrate is concentrated to a specific gravity of about 1.05 (65°C) Crude extract 200ml. Separation on a macroporous resin column according to the conventional method, after the crude extract passes through the column, it is eluted with a gradient of 0-95% water-alcohol solution, the eluate of 40-95% ethanol is collected, the solvent is recovered, concentrated in vacuo, and dried to obtain The dry product of effective part A is 8.2 g, and the content of cyperol is determined to be 32% by the above-mentioned colorimetric method.

Embodiment 2

[0085] With the method of Example 1, operate according to the process flow diagram shown in accompanying drawing 1, take 70g dried monkey earring leaves, extract with 95% ethanol solution, separate on the macroporous resin column on the crude extract, 0-95% water- Gradient elution with alcohol solution, collecting the eluate of 40-65% ethanol, recovering the solvent, concentrating in vacuo and drying to obtain 5.3 g of active site I. Using the above-mentioned thin-layer scanning method, the content of saicinol I was determined to be 11.7%; the eluate of 65-95% ethanol was collected, the solvent was recovered, concentrated in vacuo, and dried to obtain 1.5 g of active site II. Using the above-mentioned thin-layer scanning method, the content of cylinol II was determined to be 17.7%.

[0086] Take 0.7g of active site I, separate it on a silica gel column (30g), and use chloroform:methanol:formic acid for elution in a solvent system with a volume ratio of 6:1:0.5. Evaporate to d...

Embodiment 3

[0091]Operate according to the process flow diagram shown in accompanying drawing 1, get 200g monkey earring dried leaves and add water 1800ml to decoct and extract twice at a time, medicinal liquid ultrafiltration, merging and concentrating get specific gravity about 1.05 (65 °) and take crude extract 2020ml , separated on a polyamide column according to a conventional method, and after the crude extract passed through the column, it was eluted with a gradient of 0-95% water-alcohol solution, and the eluate of 40-95% ethanol was collected, the solvent was recovered, concentrated in vacuo, and dried. 21 g of the crude product of active site A was obtained. Refined with acetone-water solvent system to obtain 15 g of refined product of active part. The content of the monkey earring phenol was 32.5% by colorimetric method.

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Abstract

The invention for new flavan derivate with preparation method and application relates to extract and separate to obtain the product from Pithecellibium Clypearia Benth. The structure formula is shown as right with R as H or gallicacyl. This invention can be used in preparing antivirus drug.

Description

technical field [0001] The present invention relates to a new compound obtained by extracting and separating Chinese medicinal material monkey earring (Pithecellibium Clypearia Benth). '-Tetrahydroxyflavan and its derivatives. Background technique [0002] Pithecellibium Clypearia Benth, a traditional Chinese medicine, is a plant of the genus Saliva in the Mimosa subfamily of Fabaceae. It is widely distributed in various provinces in southern my country. Pithecellibium Clypearia Benth is now available in anti-inflammatory tablets and capsules for the treatment of upper respiratory tract infections, acute pharyngitis, Acute tonsillitis, acute gastroenteritis, and included in the sixth volume of "National Drug Standard Chinese Patent Medicine". Monkey ear ring anti-inflammatory tablets and capsules are made from the water extract of monkey ear ring plant, which is concentrated into an extract. The content of the product is determined for gallic acid, and gallic acid has long b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/60A61K31/352A61P31/12
Inventor 药凤荷李药兰黄荣春黄詹秀美
Owner SHANHE PHARMA GUANGZHOU CITY
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