74 results about "Calcium dobesilate" patented technology

The invention relates to a composition for eliminating the interference of a calcium dobesilate medicine on creatininase-method detection. The composition comprises an R1 reagent, an R2 reagent and ahigh molecular oxidant, wherein the high molecular oxidant is one or more of high molecular peroxy acid, high molecular selenium oxide, high molecular sulfur chloride ether, N-substituted imide, water-soluble tetrazole and a Dess-Martin oxidant. The high molecular oxidant in the composition disclosed by the invention can react with the calcium dobesilate in a sample to be detected, the calcium dobesilate loses the effect of interfering enzyme-method creatinine detection and the accuracy of sarcosine-oxidase-method detection is improved, so that the problem of serious negative interference, caused by high-concentration calcium dobesilate in blood of a patient, on an enzyme-method creatinine project detection result when the patient orally takes the calcium dobesilate medicine is solved.

The embodiment of the invention discloses a human serum creatinine content detecting reagent for resisting calcium dobesilate interference. The detection reagent comprises a first reagent, a second reagent and a third reagent, wherein the first reagent comprises sodium carbonate. The detection reagent is used for determining human serum creatinine based on an enzyme method, and besides, interference of calcium dobesilate drugs in serum can be avoided. The defect for detecting creatinine by a conventional enzyme method is overcome. The embodiment of the invention further provides a human serumcreatinine content detecting method for resisting calcium dobesilate interference.

The invention relates to a kit and a method for determining triglyceride. The kit comprises a reagent group 1 and a reagent group 2, wherein the reagent group 1 comprises magnesium salts, triphosadenine, glycerokinase, glycerol lipase oxidase, peroxidase and chromogen; the reagent group 2 comprises lipoprotein lipases and 4-amino-antipyrine, wherein the chromogen is N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethoxyaniline (DAOS) or comprises DAOS. The kit and the method provided by the invention have the advantage that the interference caused by calcium dobesilate and/or etamsylate existing in the sample during the triglyceride detection can be reduced.

The invention discloses a calcium dobesilate capsule and a preparation method thereof. The calcium dobesilate capsule is prepared from calcium dobesilate, croscarmellose sodium, magnesium stearate and polyvinyl pyrrolidone, wherein every 1000 calcium dobesilate capsules contain 500g of calcium dobesilate, 20-50g of croscarmellose sodium and 2-6g of magnesium stearate. In addition, a traditional preparation method is improved in the invention, and the improved method comprises the following steps: on the basis of taking the croscarmellose sodium as a disintegrating agent and taking the magnesium stearate as a lubricating agent, adding a proper amount of the polyvinyl pyrrolidone to prepare a bonding agent; preparing the bonding agent and the calcium dobesilate as well as the croscarmellosesodium into granules by a multi-step granulation method; and spraying the ethanol solution of the magnesium stearate onto the surfaces of the granules to obtain calcium dobesilate capsules with stable quality, high dissolution rate and small content uniformity.

The invention relates to a method for preparing medicinal high-purity calcium dobesilate. The method comprises the following steps of: 1, treating a coarse product of calcium dobesilate by using an organic solvent; and 2, re-crystallizing by using an aqueous solution of ethanol, wherein the organic solvent is acetone, ethyl acetate or a mixed solvent of acetone and ethyl acetate, and a volume ratio (V/V) of the acetone to the ethyl acetate is 1:5-5:1.

The present invention relates to a series of medicine combinations for remedying diabetic chronic complication and a preparation method thereof, which are compound oral preparations (comprising troche, dispersible tablet, effervescent tablet, capsule preparation, soft capsule and granule preparation) which are mainly made from at least two active components of mecobalamin, cobamamide, vitamin B12, epalrestat, lipoic acid and calcium dobesilate and pharmic acceptable auxiliary materials. The preferential combinations of the present invention are the mecobalamin plus the lipoic acid, the mecobalamin and the lipoic acid plus the calcium dobesilate, the mecobalamin and the epalrestat plus the calcium dobesilate, the mecobalamin, the lipoic acid and the epalrestat plus the calcium dobesilate, and the mecobalamin and the vitamin B12 plus cobamamide. The present invention is mainly used for remedying the nervous lesion of the diabetic chronic complication.

The invention relates to a series of combinations of chemical drug and natural drug used for treating diabetic chronic complications and the preparation method thereof, which are the combinations formed by one or a plurality of chemical drugs and one or a plurality of natural drugs, wherein, the chemical drug is any of mecobalamin, cobamamide, vitamin B12, epalrestat, lipoic acid and calcium dobesilate, and the natural drug is any of chondroitin sulfate, ginkgo biloba extract, astragalus polysaccharide, salvia miltiorrhiza, panax notoginseng and scrophularia. The preferred combination is: mecobalamin + lipoic acid + ginkgo biloba extract, mecobalamin + lipoic acid + ginkgo biloba extract + astragalus polysaccharide + salvia miltiorrhiza + panax notoginseng + scrophularia, mecobalamin + lipoic acid + calcium dobesilate + ginkgo biloba extract, mecobalamin + lipoic acid + chondroitin sulfate+ epalrestat + calcium dobesilate + ginkgo biloba extract, mecobalamin + lipoic acid + chondroitin sulfate + epalrestat + calcium dobesilate + ginkgo biloba extract + astragalus polysaccharide + salvia miltiorrhiza + panax notoginseng + scrophularia. The combinations are used for treating the microvessel and nerve lesions of diabetic chronic complications.

The invention discloses externally-applied skin gel as well as a preparation method and application thereof, belongs to the technical field of medicines and relates to preparation of the externally-applied skin gel from calcium dobesilate and any one active pharmaceutical ingredient of metronidazole, tinidazole and ornidazole for the first time. In weight, per 100.0g of externally-applied skin gel contains 1.0g to 8.0g of calcium dobesilate and 0.1g to 3.0g of metronidazole, or tinidazole or ornidazole. The externally-applied skin gel can be used for treating acne rosacea and acne; the calcium dobesilate in the gel can be used for improving the blood circulation of skin and reducing the telangiectasis of the skin; and metronidazole, or tinidazole or ornidazole has an effect of exterminating worms and mites on the skin.

The invention provides a preparation method of stable calcium dobesilate and overcomes the defect in the prior art. According to the invention, a dry granulating method is used for controlling water content in the preparation process, and obviously reducing degradation and increasing stability. Acceptable carrier or excipients and other pharmaceutic adjuvants are added into the prescription for preparing common tablet, oral disintegrating tablet, chewing tablet, film coated tablet, effervescent tablet, particulate agent, capsule, electuary, powder, suspension or sustained release agent.

The present invention discloses a calcium dobesilate dispersible tablet and a preparation method thereof. The calcium dobesilate dispersible tablet contains, by weight, a main drug calcium dobesilate, and auxiliary materials such as 1-42% of cross-linked povidone, 0.5-42% of microcrystalline cellulose, 2-44% of lactose and 0.01-15% of magnesium stearate. According to the present invention, a direct powder tabletting method is adopted to prepare the calcium dobesilate dispersible tablet; the method has characteristics of simple operation, time saving, reduction of times of calcium dobesilate exposed to air and light, and reduction of moisture absorption and light instability; the prepared calcium dobesilate dispersible tablet has a smooth surface morphology, and can be completely disintegrated within 2 min and screened with a 2# sieve, and the dissolution rate of the prepared calcium dobesilate dispersible tablet in water and a dilute hydrochloric acid solution within 5 min can achieve more than 90%; and the preparation method has characteristics of simple preparation process and time saving, and the prepared calcium dobesilate dispersible tablet has characteristics of smooth surface, good dispersion uniformity and high dissolution rate, and is suitable for industrial production.

The invention belongs to the technical field of medicine preparation, and in particular relates to a calcium dobesilate capsule composition. The calcium dobesilate capsule composition is characterized by being prepared from the following components in parts by weight: calcium dobesilate, carboxymethyl starch sodium, magnesium stearate, 90 percent of zein and a proper amount of ethanol solution. The long-term stability of the composition is obviously improved.

The invention provides a calcium dobesilate medical composition with high drug loading capacity. The composition comprises a quick release part and a slow release part and is combined by the two parts in a single unit or multiple units. The calcium dobesilate in the quick release part accounts for 10-40% of total weight of calcium dobesilate, while the calcium dobesilate in the slow release part accounts for 60-90% of total weight of calcium dobesilate. The single dose of the composition comprises 500-100mg of calcium dobesilate. According to Chinese pharmacopoeia, in pH6.8 buffer liquid, the quick release part of the calcium dobesilate medical composition is quickly released within 30 minutes by a dissolution rate detection slurry method, and the total release amount of calcium dobesilate reaches over 80% of the total weight in 12-16 hours. According to the invention, not only is medicine in initial period relatively more released to solve the problem of over-slow effect of the medicine, but also good slow release effect can be obtained just by relatively less amount of slow release auxiliary materials because calcium dobesilate in the slow release part is reduced, thereby avoiding the problem that the preparation in unit dosage is overlarge and hard to swallow. The composition has greater clinical application value. The composition provided by the invention is simple and accessible and is suitable for industrialized production.

The invention relates to a creatinine kit capable of eliminating negative deviation interference in a creatinine determination caused by calcium dobesilate and etamsylate drugs in serum and a preparation method thereof. Key points of a technical scheme of the invention are that the creatinine kit includes a reagent R1 and a reagent R2, wherein the reagent R1 includes buffer, creatinase, sarcosineoxidase, ascorbic acid oxidase, peroxidase or catalase, serum albumin, nonionic surfactant, preservative, Trinder's reagent A, laccase or metalic acid salt; and the reagent R2 includes buffer, serum albumin, creatinine enzyme, preservative and Trinder's reagent B. The invention overcomes a defect of inaccurate creatinine determination due to the presence of the negative deviation caused by calciumdobesilate and etamsylat in serum samples when the clinical tests of creatinine determination are being carried out in various hospitals, and the invention is suitable for the detection of serum creatinine by an automatic biochemical analyzer.

The invention provides a calcium dobesilate dispersible tablet and a preparation method thereof. The calcium dobesilate dispersible tablet comprises the following raw materials: calcium dobesilate, afilling agent, a disintegrating agent, an adhesive and a lubricating agent, wherein the weight parts of the calcium dobesilate, the filling agent, the disintegrating agent, the adhesive and the lubricating agent account for 29 to 50 percent, 35 to 55 percent, 3 to 13 percent, 0.2 to 1 percent and 0.4 to 2 percent of the total weight of the calcium dobesilate dispersible tablet. According to the scheme, the bioavailability of the calcium dobesilate can be improved.

The invention relates to a calcium dobesilate capsule composition, which comprises calcium dobesilate serving as an active ingredient, a filling agent and a lubricating agent, wherein the filling agent is microcrystalline cellulose preferably, the lubricating agent is a mixture of silicon dioxide and atoleine, and a weight ratio of the silicon dioxide to the atoleine is (1:1)-(1:3). According to the calcium dobesilate capsule composition, by optimizing a formula and a process, the problem of poor stability during long-term storage is solved well to ensure the quality of medicines.

Antirust lubricating oil is disclosed. The lubricating oil includes, by weight, 65-80 parts of mineral oil, 12-16 parts of dicyclopentadiene, 7-13 parts of methacrolein, 5-9 parts of methacrylamide, 8-12 parts of 5-norbornene-2-methanol, 2-5 parts of calcium dobesilate, 1-4 parts of dolomite dust, 9-13 parts of ethopabate, 7-12 parts of sodium naphthalene-1-acetate, 5-10 parts of 5-hydroxytryptophan, 4-8 parts of zinc hypophosphite, 12-17 parts of 4-bromophenoxybenzene and 6-11 parts of acetazolamide. The lubricating oil has good antiwear, antirust and lubricating effects and a production process is simple.

The invention belongs to the technical field of medicines, and concretely discloses a calcium dobesilate capsule composition and a preparation method. Calcium dobesilate is used as a raw material, and the composition also comprises one or a plurality of pharmaceutically acceptable excipients. The preparation method of the composition comprises the following steps: mixing calcium dobesilate with magnesium stearate to obtain a mixture, mixing the mixture with a selectable diluent, adding a proper amount of an adhesive to prepare a soft material, sieving to prepare wet particles, drying the wet particles, sieving for granulation, adding a corresponding lubricant, mixing, and filling to a capsule. The composition has the advantages of simple preparation method, consistency of a dissolution curve with that of reference listed drugs, and guarantee of the effective plasma concentration and the safety. The composition can be used for the diabetic microangiopathy.

The invention relates to a calcium dobesilate tablet and a preparation method thereof, and belongs to the technical field of medicine. The calcium dobesilate tablet is prepared from, by weight, 200-300 parts of calcium dobesilate, 5-15 parts of mannitol, 2-4 parts of sodium dihydrogen citrate anhydrous, 6-8 parts of sodium metabisulfite, 0.2-0.5 part of anhydrous citric acid, 30-50 parts of absolute ethyl alcohol and 20-40 parts of magnesium stearate. According to the prepared calcium dobesilate tablet, through 6-month accelerated test inspection, the characters all meet the specification, the dissolution rate is qualified, the dry weight loss change range does not exceed +/-0.5%, related substances have the little rising tendency, the total impurity increasing amplitude does not exceed 0.02%, and the content ranges from 98 percent to 101 percent; all the inspection indexes do not change obviously, the quality is stable, and therefore the calcium dobesilate tablet can be more suitable for clinical application.

The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for treatment of diabetic retinopathy. The traditional Chinese medicine composition comprises the following components: rhizoma acori graminei, semen cassiae, cistanche, root of kudzu vine, feather cockscomb seed, radix codonopsis, fructus viticis, Chinese wolfberry, semen plantaginis, radix paeoniae alba, dogwood, licorice, dodder seed, rhizoma cimicifugae, hedge prinsepia nut, chrysanthemum, butterflybush flower, Rhizoma Chuanxiong, polygonati rhizoma processed with yellow wine, prepared rehmannia root, Phellodendron amurense and Radix Astragali. The traditional Chinese medicine composition has good effects on preventing and treating the diabetic retinopathy, and can significantly reduce the production of retinal microangioma of the diabetic retinopathy, and compared with commonly-used diabetic retinopathy therapeutic drug calcium dobesilate, the traditional Chinese medicinecomposition is more remarkable in curative effect.

The invention relates to a calcium dobesilate capsule and a preparation method, and belongs to the technical field of pharmaceutical preparations. According to the technical scheme, the calcium dobesilate capsule is prepared from a therapeutically effective dose of calcium dobesilate, filler and a lubricant. The capsule is characterized by being produced with a wet granulation and dry granulation combined process. The materials are subjected to wet granulation before the dry granulation process, the problem of poor mobility due to too large proportion of calcium dobesilate in a prescription is solved, and the problem of high variability of each sample in the early stage of the dissolution process is also solved.