Calcium dobesilate injection

A technology of calcium dobesilate and injection, which is applied in the directions of anhydride/acid/halide active ingredients, medical preparations with non-active ingredients, cardiovascular system diseases, etc. and quality issues

Inactive Publication Date: 2007-10-31
SHENYANG XINGQI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oxidation, polymerization, etc. are prone to occur in the solution state, thereby reducing the stability and quality of the preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0011] Weigh 5g of calcium dobesilate, 5g of mannitol, and 0.5g of vitamin C, add 100mL of water for injection to dissolve, adjust the pH to 5.5, and filter through a 0.45μm microporous membrane; place the filtrate in the dark at 0°C for 6 hours , 0.1 μm microporous membrane filter, diluted with water for injection to 500mL, filled (2mL / bottle), or freeze-dried, sterilized by radiation, and packaged.

example 2

[0013] Weigh 5g of calcium dobesilate, 5g of mannitol, 0.5g of vitamin E and add 100mL of water for injection to dissolve, adjust the pH value to 5.5, filter through a 0.45μg microporous membrane; place the filtrate at 1°C for 10 hours, Filter through a microporous membrane, dilute to 500mL with water for injection, spray dry, potting (5mg / bottle), sterilize by radiation, and pack.

example 3

[0015] Weigh 5g of calcium dobesilate, 5g of mannitol, 0.5g of sodium sulfite and add 100mL of water for injection to dissolve, adjust the pH value to 5.5, and filter through a 0.45μm microporous membrane; Pore ​​membrane filtration, diluted with water for injection to 500mL, spray-dried, potted (5mg / bottle), sterilized by radiation, and packaged.

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PUM

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Abstract

The invention discloses an injection and powder needle injection for eyeball rear injection of benzyl sulfonic acid calcium, which is characterized by the following: allocating 0. 2-20 / mL benzyl sulfonic acid calcium and 0-50% medicinal findings; setting the medicinal findings as bone holding agent and antioxidant; choosing the bone holding agent from one of manna sugar, vitamin C, carbamide, antacidin, dextran, polyvinylpyrrolidone and aminoacetic acid or their mixture; choosing the antioxidant from one of vitamin C, vitamin E, sodium sulfite, sodium acid sulfite, sodium metabisulfite, natrium hyposulfidum, methilanin, thiourea, editic acid disodium and citric acid or their mixture. This powder needle injection is one of spraying or hot air dry injection, powder needle injection and freezing dry powder needle injection.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing calcium dobesilate. More specifically, it is an injection and a powder injection prepared from calcium dobesilate, and the present invention also relates to the injection being used for retroocular injection. Background technique [0002] Calcium Dobesilate is a new type of vascular protection agent, and its main pharmacological effects are: reduce its permeability, increase resistance; improve lymphatic fluid return, reduce edema; reduce blood plasma viscosity, correct albumin / The globulin ratio reduces the high aggregation of platelets, thereby preventing thrombus formation and improving the flexibility of red blood cells. This product can also inhibit the high permeability caused by vasoactive substances (histamine, 5-hydroxytryptamine, bradykinin, hyaluronidase, prostaglandin) on microvessels, reduce the damage of vascular intima, and improve the biological function of basem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/19A61K9/14A61K31/185A61K47/20A61K47/16A61K47/10A61P9/14A61P9/10
Inventor 刘继东杨宇春刘有平
Owner SHENYANG XINGQI PHARM CO LTD
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