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Calcium dobesilate capsule composition

A technology of calcium dobesilate and composition, which is applied in capsule delivery, drug combination, anhydride/acid/halide active ingredients, etc. It can solve problems such as poor stability, light instability, easy oxidation, etc., and improve fluidity , stable sample quality and easy operation

Inactive Publication Date: 2012-07-18
KANGYA OF NINGXIA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The molecular structure of calcium dobesilate capsules contains 2 phenolic hydroxyl groups, which determine its chemical properties such as hygroscopicity, light instability and easy oxidation. The present invention solves the problem well by optimizing the prescription and process. The problem of poor stability in long-term storage, in order to ensure the quality of drugs

Method used

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  • Calcium dobesilate capsule composition
  • Calcium dobesilate capsule composition
  • Calcium dobesilate capsule composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The present invention is further described below by way of examples.

[0032] Embodiment one

[0033] prescription:

[0034]

[0035] Process:

[0036] 1. The calcium dobesilate is crushed through an 80-mesh sieve, and the microcrystalline cellulose is passed through an 80-mesh sieve;

[0037] 2. Weigh the prescription amount of calcium dobesilate and microcrystalline cellulose, and mix them;

[0038] 3. Use 45% ethanol as a wetting agent to make soft materials, pass through a 28-mesh sieve to granulate, dry the wet granules at 80°C, and take out the dry granules;

[0039] 4. Add the prescribed amount of liquid paraffin and silicon dioxide, mix evenly, pass through a 28-mesh sieve for granulation, and pack into No. 0 capsules.

Embodiment 2

[0041]

[0042] Process:

[0043] 1. The calcium dobesilate is crushed through an 80-mesh sieve, and the microcrystalline cellulose is passed through an 80-mesh sieve;

[0044] 2. Weigh the prescription amount of calcium dobesilate and microcrystalline cellulose, and mix them;

[0045] 3. Use 45% ethanol as a wetting agent to make soft materials, pass through a 28-mesh sieve to granulate, dry the wet granules at 80°C, and take out the dry granules;

[0046] 4. Add the prescribed amount of liquid paraffin and silicon dioxide, mix evenly, pass through a 28-mesh sieve for granulation, and pack into No. 0 capsules.

Embodiment 3

[0048]

[0049] Preparation Process:

[0050]1) The calcium dobesilate is pulverized through an 80-mesh sieve, and the filler is passed through an 80-mesh sieve;

[0051] 2) Weigh the prescription amount of calcium dobesilate, microcrystalline cellulose and lactose, and mix them;

[0052] 3) Use 45% ethanol as a wetting agent to prepare soft materials, pass through a 28-mesh sieve to granulate, dry the wet granules at 80°C, and take out the dry granules;

[0053] 4) Add the prescribed amount of silicon dioxide and liquid paraffin, mix evenly, pass through a 28-mesh sieve for granulation, and pack into No. 0 capsules.

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Abstract

The invention relates to a calcium dobesilate capsule composition, which comprises calcium dobesilate serving as an active ingredient, a filling agent and a lubricating agent, wherein the filling agent is microcrystalline cellulose preferably, the lubricating agent is a mixture of silicon dioxide and atoleine, and a weight ratio of the silicon dioxide to the atoleine is (1:1)-(1:3). According to the calcium dobesilate capsule composition, by optimizing a formula and a process, the problem of poor stability during long-term storage is solved well to ensure the quality of medicines.

Description

technical field [0001] The invention relates to a composition of calcium dobesilate capsules, in particular to a pharmaceutical preparation, formula composition and preparation method of calcium dobesilate. Background technique [0002] Calcium dobesilate (calcium dobesilate) is chemically called 2,5-dihydroxybenzenesulfonate calcium monohydrate, which is a chemically synthesized capillary protective drug, developed by the Swiss Dela Rand Company. The drug was included in the European Pharmacopoeia in 1997 and the British Pharmacopoeia in 1998, and was introduced to the domestic market in June 2001. In foreign countries, calcium dobesilate has been used to treat diabetes and varicose veins, hemorrhoids, myocardial infarction and itchy dermatitis caused by microcirculation disturbance since the 1970s. In areas with higher living standards, elderly people take it for a long time to improve microcirculation, and it is recognized as the only mature product for the prevention an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/185A61K47/44A61K47/38A61K47/04A61P9/14
Inventor 杨亚军李娟
Owner KANGYA OF NINGXIA PHARMA
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