Composition for eliminating interference of calcium dobesilate medicine on creatininase-method detection

A technology of calcium dobesilate and a composition, applied in the field of medical testing, can solve problems such as interference in detection by creatinase method

Active Publication Date: 2018-10-09
WUHAN HANHAI NEW ENZYMES BIOLOGICAL TECH CO LTD
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a composition for eliminating the interference of cal

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  • Composition for eliminating interference of calcium dobesilate medicine on creatininase-method detection
  • Composition for eliminating interference of calcium dobesilate medicine on creatininase-method detection
  • Composition for eliminating interference of calcium dobesilate medicine on creatininase-method detection

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Embodiment Construction

[0023] The present invention provides a composition for eliminating the interference of calcium dobesilate drug on creatinine enzymatic detection. In order to make the purpose, technical scheme and effect of the present invention clearer and clearer, the present invention will be further described in detail below. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0024] The following test methods are conventional methods unless otherwise specified, and the test materials used can be easily obtained from commercial companies unless otherwise specified.

[0025] A composition for eliminating the interference of calcium dobesilate drugs on creatinine enzyme detection, which includes: R1 reagent, R2 reagent and polymer oxidant;

[0026] The polymer oxidant is one or more of polymer peroxyacids, polymer selenium oxides, polymer chlorosulfides, N-imides, water-soluble tetrazole, ...

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Abstract

The invention relates to a composition for eliminating the interference of a calcium dobesilate medicine on creatininase-method detection. The composition comprises an R1 reagent, an R2 reagent and ahigh molecular oxidant, wherein the high molecular oxidant is one or more of high molecular peroxy acid, high molecular selenium oxide, high molecular sulfur chloride ether, N-substituted imide, water-soluble tetrazole and a Dess-Martin oxidant. The high molecular oxidant in the composition disclosed by the invention can react with the calcium dobesilate in a sample to be detected, the calcium dobesilate loses the effect of interfering enzyme-method creatinine detection and the accuracy of sarcosine-oxidase-method detection is improved, so that the problem of serious negative interference, caused by high-concentration calcium dobesilate in blood of a patient, on an enzyme-method creatinine project detection result when the patient orally takes the calcium dobesilate medicine is solved.

Description

technical field [0001] The invention belongs to the field of medical testing, and in particular relates to a composition for eliminating the interference of calcium dobesilate medicine on creatinine enzymatic detection. Background technique [0002] Creatinine, the end product of creatine and creatine phosphate metabolism, is mainly produced by the non-enzymatic reaction of creatine phosphate in muscle. The determination of creatinine in the blood can tell the degree of renal function damage. The higher the creatinine detection value, the more serious the renal function damage. [0003] Alkaline picric acid method is a traditional creatinine detection method, which has been used for a long time. However, its stability is poor and has been gradually eliminated by various clinical laboratories; Precision, as well as high linear range, has become the main creatinine detection method in clinical departments. [0004] Calcium dobesilate is a vascular protective drug, mainly use...

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Application Information

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IPC IPC(8): G01N33/70G01N33/53
CPCG01N33/5306G01N33/70G01N2800/347
Inventor 王存理蔡凯杨广宇
Owner WUHAN HANHAI NEW ENZYMES BIOLOGICAL TECH CO LTD
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