67 results about "High variability" patented technology

The invention is directed to methods of generating sequence profiles of populations of nucleic acids, whose member nucleic acids contain regions of high variability, such as populations of nucleic acids encoding T cell receptors or B cell receptors. In one aspect, the invention provides pluralities of sets of primers for generating nested sets of templates from nucleic acids in such populations, thereby insuring the production of at least one template from which sequence reads are generated, despite such variability, or dispite limited lenghs or quality of sequence reads. In another aspect, members of such populations are bidirectionally sequenced so that further sequence information is obtained by analyzing overlapping sequence reads in the zones of highest variability.

The invention is directed to methods of generating sequence profiles of populations of nucleic acids, whose member nucleic acids contain regions of high variability, such as populations of nucleic acids encoding T cell receptors or B cell receptors. In one aspect, the invention provides pluralities of sets of primers for generating nested sets of templates from nucleic acids in such populations, thereby insuring the production of at least one template from which sequence reads are generated, despite such variability, or dispite limited lengths or quality of sequence reads. In another aspect, members of such populations are bidirectionally sequenced so that further sequence information is obtained by analyzing overlapping sequence reads in the zones of highest variability.

A system, method and program product for evaluating search algorithms. A method is provided that includes: defining a population of searches and database records from a search history database; applying a sampling method and direct sampling rates to each search / record pair in the population using a computing system, wherein search / record pairs having a higher variability relative to the population are assigned a relatively higher probability; randomly sampling a direct sample of search / record pairs with the computing system using the direct sampling rates to increase a likelihood of obtaining search / record pairs having the higher variability; running a search algorithm and measuring errors for the direct sample and / or for an associated indirect sample; and calculating an estimated error rate for the search algorithm using inverse probability weighting.

A method for forecasting a future inventory demand includes receiving historical demand data associated with a part number and statistically analyzing the historical demand data associated with one or more part numbers to identify each part number as one of a seasonal part number, a quasi-seasonal part number, a high variability part number, or a non-seasonal part number. If the part number is identified as a seasonal part number, a first inventory requirement for a first predetermined portion of a future demand period is estimated. If the part number is identified as a quasi-seasonal part number, a second inventory requirement for a second predetermined portion of a future demand period is estimated, wherein the second predetermined portion of the future demand period is a multiple of the first predetermined portion. If the part number is identified as a high variability part number, a third inventory requirement for a third predetermined portion of a future demand period is estimated.

The present invention relates to prompt-release oral pharmaceutical compositions containing one or more active principles solubilised, suspended or embedded in a suitably formulated amphiphilic matrix for improving in vitro and in vivo bioavailability of medicaments sparingly absorbed through the oral route and / or with problems of high variability of absorption in the gastrointestinal tract.

The invention provides a mitochondrial gene sequence for identifying authenticity and quality of Cordyceps sinensis and an operation method thereof. According to the method, differences of mitochondrial genes between ghostmoth and other lepidopteran insects are compared and thus high-variability areas can be searched. Specific primers of the ghostmoth are designed to obtain sequences of corresponding sections of mitochondria of host insects; if a nucleotide difference rate is less than 1-1.5 %, the insects are determined to be a same species but different individuals, and if the nucleotide difference rate is more than 6 %, the insects are determined to be a same genus but different species, thereby not only identifying whether to-be-detected samples are the Cordyceps sinensis formed with Hepialus larvae as the host insects, but also determining producing areas of the to-be-detected samples, and thus determining the authenticity and grades of the to-be-detected samples The method is simple in steps, easy to operate, and few in sample amount, and can minimize sample loss. According three pairs of the specific primers provided by the invention, the authenticity and the grades of the samples can be rapidly and conveniently detected through detecting whether the samples have same or similar nucleotide sequences as well as similarity of the nucleotide sequences.

The invention discloses a training method of a dialogue generation model and a dialogue generation method and device, and relates to the field of artificial intelligence. The method comprises the following steps: encoding a context sample to obtain a first hidden layer variable, and identifying the first hidden layer variable to obtain a prior hidden layer variable; encoding the reply sample to obtain a second hidden layer variable; encoding the reply similar sample to obtain a third hidden layer variable; according to the Gaussian mixture distribution of the first hidden layer variable, the second hidden layer variable and the third hidden layer variable, identifying to obtain a posterior hidden layer variable; and matching the prior hidden layer variable and the posterior hidden layer variable, and performing adversarial training on the dialogue generation model. According to the method, similar samples in a sample set are adopted, posteriori distribution of a dialogue generation model is fitted through Gaussian mixture distribution of the similar samples, the purpose of fitting more complex semantics is achieved, and complex semantics and high variability of dialogues can be captured.

A business process (BP) adaptation system (400) includes a High-Variability enriched Goal Model (HVGM) (402) that captures and refines goals of a business process (BP) while modeling alternative options where the model captures non-functional or quality attributes used in an evaluation of a performance of the BP and an estimation of how various BP alternatives affect the quality attributes. The system further includes a High-Variability workflow-level / directly Executable Model (HVEM) (404), where the system is based on goal modeling and analysis for eliciting intentions behind a BP to achieve a desired goal and the HVGM explicitly models non-functional or quality concerns. The system can further include a semi-automatic generator (604) of BP metrics based on the quality attributes specified in the HVGM and a runtime infrastructure (610) where each deployed BP instance reflects a configuration selected for that instance in a corresponding portion of the HVGM.

The invention discloses a device for automatically detecting the high pressure resistance and electric function of an electronic component product. In the device, by utilizing the self-gravitation of the product on a tapered slideway, the product automatically slides down; a jig for testing the pressure resistance and electric property is arranged on the slideway; and the device controls a device to distinguish the tested good products and defective products through signals fed back by a tester. The device for automatically detecting the high pressure resistance and electric function comprises a feeding mechanism, a high-pressure test part, an electric test part and an automatic defective product sorting part which are arranged on a work table panel in an inclined mode from the high-order end to the low-order end and are in communicated connection through the slideway in turn, and a high-pressure tester interface, an electric tester interface and a central control system connected with and controlling each part which are arranged inside the work table. The device for automatically detecting the high pressure resistance and electric function of the electronic component product has the advantages of high production efficiency, stable capacity, high variability, high applied elasticity and high device productivity, and has the advantages of saving resources and management cost, solving the problem of false reject of the product quality so as to achieve more stable product quality, reducing operation cost or device cost, and saving the labor.

The present invention relates to prompt-release oral pharmaceutical compositions containing one or more active principles solubilised, suspended or embedded in a suitably formulated amphiphilic matrix for improving in vitro and in vivo bioavailability of medicaments sparingly absorbed through the oral route and / or with problems of high variability of absorption in the gastrointestinal tract.

The invention discloses a measurement method of a continuous frequency-modulated wave-system radar water level gauge. Measurement of a water level under conditions of a large measuring range and high variability is realized by combining a Chirp-Z+FFT method with an automatic gain control method, and the continuous frequency-modulated wave-system radar water level gauge measurement method has the characteristics of high precision, high stability, low power consumption, high interference resistance, high repetitiveness and the like. The continuous frequency-modulated wave-system radar water level gauge can be independently used as a sensor for high-precision water level measurement, and also combined with an acquisition terminal to form an intelligent integrated monitoring device, so as to realize water level prewarning and unattended automatic water level monitoring.

Control transistors and memory cells within 3D NAND Flash memory arrays may both be created using the same technology, such as charge trapping structures, to simplify the fabrication process. However, the resulting control transistors may initially have higher variability in threshold voltages, when compared to traditional gate-oxide-based control transistors. Provided are exemplary techniques to trim control transistors to provide increased reliability and performance during array operation.

Bipolar integrated circuits employing SiGe technology incorporate the provision of mask-selectable types of bipolar transistors. A high-performance / high variability type has a thin base in which the diffusion from the emitter intersects the base dopant diffusion within the “ramp” of Ge concentration near the base-collector junction and a lower performance / lower variability type has an additional epi layer in the base so that the emitter diffusion intersects the Ge ramp where the ramp has a lower ramp rate.

A mooring component comprises a plurality of different deformable elements formed of an elastomeric material. The component has a tensile length L and at least one of the elements has a length L′<L. As the mooring component comprises a plurality of different elastomeric elements, each having its own unique elastic (i.e. reversible) stress-strain response, the overall response of the component is a composite elastic response resulting from a combination of the responses of each of the plurality of elastomeric elements. The mooring component can form part of a mooring system for floating devices and sea-based structures such as renewable energy devices, including wave energy conversion devices, tidal turbines and tidal platforms, fish farms, oil rigs and off-shore wind farms, especially in low scope or high variability environments.

The invention relates to a production processing method of a subway train, particularly to a method for constructing a station-system beating type production mode of a subway train, so that technical problems that the application scope of the production line is small, the workers grouped based on skill types for working with high variability, the working management is confused, the production efficiency is low, various management measures can not be done truly, and the traceability is poor in the prior art are solved. The method comprises: standard stations are established, a production line of a whole subway train is cut into separate standard stations, when products flow on the production line, workers completes regulated working contents within one beat, and the workers and delivery men are separated by relative stay areas of the products; the time for completing two same products, two same services, or two same batches of products continuously is determined and thus the beat is determined; and then, with a standard station as a working organization unit, production is organized by assembly line work in a beating type balanced production mode.

The invention discloses a shuttling intracellular antibody TAT-4F for H3N2-type canine influenza virus. The H3N2 virus is A-type influenza virus, the main neutralizing antibody is from hemagglutinin (HA), therefore, the HA becomes an original main research target; then the influenza virus has high variability, the immune cross reaction among different variable branches is weaker, M1 antibody can be combined with M1 protein to inhibit the activity and disturb multiplication, transcription and release of the influenza virus so as to play a role in resisting the virus; therefore, the M1 protein is selected for preparing the corresponding antibody to obtain stable titer, coupling the antibody with TAT protein PTD (Protein Transduction Domain) capable of transducing biomacromolecules into cellsand expressing fusion protein TAT PTD-M1 ScFv, and then a shuttling antibody for resisting the canine influenza virus is prepared to provide a new path for treating the canine influenza virus.

The invention relates to a real-time video congestion control method and device based on data driving. The method is mainly used for an end-to-end internet video transmission application scene in a wireless network. The method mainly comprises a learning-based rate control strategy and a low-delay fairness model. According to historical data in a sliding window, a linear relation between link delay change and rate change is described by means of online linear regression; And according to the linear relation, an optimal sending rate can be decided by combining with the fairness function based on the load target provided by the invention. In the whole decision process, the characteristic that the wireless network has high variability is fully considered, the long-term change of the network environment is sensed through historical data, and the sending rate is adjusted by means of the link delay to adapt to the instantaneous fluctuation of the network, so that the purposes of improving the bandwidth utilization rate and reducing the link delay are achieved, and the user experience of real-time video application is improved.

A method and apparatus for establishing product items unique identity for purpose of anti-counterfeiting or anti-theft is disclosed. It employs a fluorescent taggant embedded in product item, template, digitally based Encoder and Decoder. The taggant comprising plurality of fluorescent entities which in turn may comprise such distinct geometric and spectral optical characteristics-attributes as relative locations, emission / absorption spectra, polarization degrees and post luminanc delay and duration times. Such uniqueness is determined by the presence of a combination of a wide variety of fluorescent materials used during the application. The set of fluorescent entities are result of a random process and form a product item's fingerprint. The said template is a particular digitized representation of a taggant. The Encoder may comprise a camera, LED array based activator, configured to follow a particular illumination sequence and computation unit. The said camera further comprises at least two polarizing filters and template generator and the respective controllers. The Decoder may comprise at least one camera identical to the of the Encoder, at least one template / taggant readers and a computation unit, which may be shared with the said Encoder. Product item identity is based on the fluorescent taggant uniqueness, with the later embedded into the product in a non separable way. After the extracted attribute values assiciated with the taggant, are digitized. Digitazing comprises mixing with chaff (spurious) patterns of the same format, error correction, transformation in a non invertible and compression and encryption. This forms a template, embedded in the product in a readable form. The decoding comprises feature extraction of taggant, reading template and decrypting, its content, error correction, decompression. Then the extracted and the decoding results are cross-matched in order to identify the product item. Irreproducibility of a plurality of fluorescent entities and high degree of security of its digital representation due to encryption, high variability of LED patterns and non-invertible transformation is a basis of a chaosmetric anti-counterfeiting solution disclosed in the present invention.

The invention discloses equipment for testing the pins of electronic element products automatically, which consists of a machine shell, a chute device arranged on the machine shell obliquely, an air cylinder device arranged on the chute device, a feeding mechanism arranged on the upper part of the chute device and a material collecting device arranged in the lower middle part of the chute device, wherein the chute device is comprised of an upper testing chute and a lower testing chute, which both are provided an industrial camera component connected with an external computer; and the chute device is also provided with a plurality of pairs of sensors. Compared with the prior art, the equipment has the advantages of saving resources and management cost, solving the problem of product quality misjudgement, making product quality more stable, reducing product wire replacement time, improving equipment utilizability, saving labor, along with high production efficiency and high productivity stability, high variability and high application elasticity.

The invention concerns a portable device (1) for measuring the position, shape and / or size of an object. The device comprises a carrier element (2), at least one transmission unit for generating and transmitting visible radiation towards the object and at least one receiving unit for receiving the radiation imaging the object. The transmission unit and receiving unit are mounted in a defined position relative to each other on the carrier element (2). Modular construction provides high variability of the device (1) so that it can be used flexibly for various applications. In particular, the transmission unit is mounted to a first holding element (3) and the receiving unit to a second holding element (4), wherein the holding elements (3, 4) can be introduced together with the transmission unit or receiving unit from outside the carrier element (2) to predeterminable mounting positions (5, 6) of the carrier element (2) and be mounted there using mounting means (7, 8) which can be accessed from outside of the carrier element (2).

The invention provides a short-refraction investigation method for the undulating surface of the terrain high-variability area in the ultra-thick loess highland. The short-refraction investigation method for the undulating surface of the terrain high-variability area in the ultra-thick loess highland comprises the steps that 1, a short-refraction observing system is used, an encounter observing system is used, and shot points are laid in a certain receiving arrangement mode; 2, wave detectors are embedded, and coordinates of each receiving point and each shot point are actually measured according to channel distances arranged in a short-refraction mode; 3, pit cannon excitation is adopted, and selection of the well depth and the explosive quantity conforms to the safety standard; 4, short refraction is explained, refraction tomographic inversion is carried out, and an exquisite near-surface structural model is set up. According to the short-refraction investigation method for the undulating surface of the terrain high-variability area in the ultra-thick loess highland, exquisite near-surface investigation can be carried out on the high-variability area in the ultra-thick loess highland, the defect that near-surface information can not be extracted accurately and easily in similar areas is made up, and the method has high application and popularization value in the whole loess highland.

Methods, systems, and computer program products for suggesting sensor placements are provided herein. A method includes simulating the concentration of a pollutant over an area covered by a sensor network grid by applying models to an emission inventory corresponding to the area; computing any discrepancy between the simulated concentration and historical data; applying scaling vectors to the first version to generate scaled versions of the emission inventory; re-simulating the concentration of the pollutant by applying the models to the scaled versions, and computing any discrepancy between the re-simulated concentrations and the historical data; identifying each scaling vector that corresponds with a discrepancy within a pre-determined range; applying the identified scaling vectors to an emission inventory value of each of the grid blocks to generate scaled emission inventory values; determining the grid blocks having high variability within scaled emission inventory values; and suggesting a sensor placement at the determined grid blocks.

The invention discloses a method for manufacturing an MEMS microphone support plate with porous sound inlet and single-hole sound transmission, and the method can omit a traditional microphone mounting process for realizing the cavity expansion of a sound transmission path through the chip mounting through a hole steel sheet through the design of embedding a sound cavity in the support plate, thereby simplifying the chip mounting process, and reducing the cost investment. Through the design of embedding the sound cavity in the support plate, the sound transmission sound cavity with high variability is formed in the sound path of the microphone, which is conducive to improving the frequency response and improving the performance of the microphone. Through the miniature porous design of thesound inlet sound hole, the sound inlet volume can be ensured, the dustproof effect is achieved, the butt joint with the chip through the single sound transmission hole in the embedded sound cavity isachieved, and the sound transmission performance of the microphone can be greatly improved; And the single-process production process is mature, the production cost investment is low, the improvementeffect is remarkable, and the performance of terminal products is improved.

A method for forecasting a future inventory demand includes receiving historical demand data associated with a part number and statistically analyzing the historical demand data associated with one or more part numbers to identify each part number as one of a seasonal part number, a quasi-seasonal part number, a high variability part number, or a non-seasonal part number. If the part number is identified as a seasonal part number, a first inventory requirement for a first predetermined portion of a future demand period is estimated. If the part number is identified as a quasi-seasonal part number, a second inventory requirement for a second predetermined portion of a future demand period is estimated, wherein the second predetermined portion of the future demand period is a multiple of the first predetermined portion. If the part number is identified as a high variability part number, a third inventory requirement for a third predetermined portion of a future demand period is estimated.

A radio frequency (RF) micro-electro-mechanical systems (MEMS) switch and high yield manufacturing method. The switch can be fabricated with very high yield despite the high variability of the manufacturing process parameters. The switch is fabricated with monocrystalline material, e.g., silicon, as the moving portion. The switch fabrication process is compatible with CMOS electronics fabricated on Silicon-on-Insulator (SOI) substrates. The switch comprises a movable portion having conductive portion selectively positioned with a bias voltage to conductively bridge a gap in a signal line.

The present invention relates to an HIV (human immunodeficiency virus) immunogen that stimulates broad-spectrum neutralizing antibodies and a vaccine prepared from the HIV immunogen. The HIV immunogen contains a peptide sequence which comprises HIV 4E10 and / or 2F5 and / or Z13 epitope sequences. The immunogen of this invention can stimulate HIV-specific broad-spectrum neutralizing antibodies, and overcomes the delaying problem of antibody induction due to high variability of HIV in the prior art. Animal immune experiments show that the peptide immunogen of the invention supplemented with adjuvants can induce production of specific antibodies in sera of immunized animals, and the induced antibodies has the capacity of broadly neutralizing representative HIV infected cells, and has the potential for development of clinical vaccines against HIV and auxiliary enhancement of HIV vaccine.

The present invention relates to organometallic compounds useful in the treatment of metastasis. The organometallic compounds comprise a ligand that is covalently bound to a bioactive compound, which is an inhibitor of a resistance pathway or a derivative thereof. Preferably, the organometallic compounds are half-sandwich (“piano-stool”) compounds. The compounds of the present invention offer a high variability with respect to the bioactive compound and to the nature of the ligand bound to a central transition metal.

Self-similar data communication in network traffic is modeled real time and is analyzed using a Markov modified Poissen process (MMPP) to characterize the traffic flow and to accommodate high variability in traffic flow from one time period to the other. The analysis is performed at multiple time levels using a bottom-up approach. The parameters of the model are adjustable at each level according to the traffic parameters at that level. Each model consists of 2 states of network traffic behavior comprising a bursty state representing heavy traffic conditions and an idle state representing light traffic conditions. A transition window defines the upper time interval for the receipt of packets in the bursty state and the lower time interval for the receipt of packets in the idle state. If the inter-rival times for the bursty state and the idle state become approximately equal, the model defaults to a single state model.