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Externally-applied skin gel as well as preparation method and application thereof

A gel and skin technology, applied in the field of medicine, can solve unseen problems and achieve the effects of excellent curative effect, improved curative effect and reduced quantity

Inactive Publication Date: 2012-08-22
段亚东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing pharmaceutical market, there is no report on the research and drug production of calcium dobesilate and any one of the active ingredients of metronidazole, tinidazole, ornidazole, which is made into skin external gel

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Preparation of Calcium Dobesilate Metronidazole Skin External Gel

[0031] Prescription composition: calcium dobesilate 2.5g, metronidazole 0.75g, carbomer 0.8g, hydroxypropyl methylcellulose 0.2g, hydrogenated hard castor oil 1.0g, boric acid 1.0g, propylene glycol 1.0g, sodium chloride 0.5 g, 0.025 g of ethylparaben, and water for injection were added to the full amount to prepare 100.0 g of gel for external use on the skin.

[0032] Preparation method: Dissolve calcium dobesilate and metronidazole with appropriate amount of water for injection, stir with hydroxypropyl methylcellulose, hydrogenated hard castor oil, boric acid, propylene glycol, sodium chloride, and ethylparaben respectively, and heat Dissolve it completely to form a metronidazole solution; sprinkle carbomer in water for injection, swell into a gel solution, add the above solution, autoclave, cool, filter, subpackage, and pack to obtain the product.

Embodiment 2

[0033] Example 2: Preparation of Calcium Dobesilate Metronidazole Skin External Gel

[0034] Prescription composition: calcium dobesilate 1.0-8.0g, metronidazole 0.1-3.0g, carbomer 0.1-10.0g, hypromellose 0.04-20.0g, hydrogenated hard castor oil 0.01-5.0g, boric acid 0.3-3.0g, propylene glycol 0.1-5.0g, sodium chloride 0.5-1.0g, ethylparaben 0.01-0.05g, water for injection was added to the full amount, and 100.0g of external skin gel was prepared.

[0035] Preparation method: with embodiment 1.

Embodiment 3

[0036] Example 3: Preparation of Calcium Dobesilate Tinidazole Skin External Gel

[0037] Prescription composition: calcium dobesilate 2.5g, tinidazole 0.75g, carbomer 0.8g, hydroxypropyl methylcellulose 0.2g, hydrogenated hard castor oil 1.0g, boric acid 1.0g, propylene glycol 1.0g, sodium chloride 0.5 g, 0.025 g of ethylparaben, and water for injection were added to the full amount to prepare 100.0 g of gel for external use on the skin.

[0038] Preparation method: the preparation method is the same as in Example 1, except that metronidazole is replaced by tinidazole.

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PUM

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Abstract

The invention discloses externally-applied skin gel as well as a preparation method and application thereof, belongs to the technical field of medicines and relates to preparation of the externally-applied skin gel from calcium dobesilate and any one active pharmaceutical ingredient of metronidazole, tinidazole and ornidazole for the first time. In weight, per 100.0g of externally-applied skin gel contains 1.0g to 8.0g of calcium dobesilate and 0.1g to 3.0g of metronidazole, or tinidazole or ornidazole. The externally-applied skin gel can be used for treating acne rosacea and acne; the calcium dobesilate in the gel can be used for improving the blood circulation of skin and reducing the telangiectasis of the skin; and metronidazole, or tinidazole or ornidazole has an effect of exterminating worms and mites on the skin.

Description

technical field [0001] The present invention belongs to the technical field of medicine, and relates to calcium dobesilate and any one of metronidazole, tinidazole and ornidazole, which can be used as an external gel for the treatment of rosacea and acne. Background technique [0002] Rosacea is a chronic inflammation of the nasal skin caused by the infection of worms and mites, with skin flushing and telangiectasia as the main symptoms. Acne is a chronic inflammation of the facial skin due to the blockage of skin hair follicles and sebaceous glands, accompanied by infection by Demodex mites and Corynebacterium acnes, with symptoms such as skin flushing, erythema, inflammatory papules, and telangiectasia. Metronidazole gel is the most commonly used drug for the treatment of rosacea and acne. This drug can only kill Demodex mites and Corynebacterium acnes, but cannot reduce or eliminate skin telangiectasia. Calcium dobesilate is an anti-varicose blood vessel protective agen...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61K9/06A61P17/10A61P33/14A61P33/10A61K31/185
Inventor 段亚东
Owner 段亚东
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