Supercharge Your Innovation With Domain-Expert AI Agents!

Medicinal composition and tablet containing salicylic acid methyl ester lactoside and preparation methods thereof

A technology of methyl salicylate and lactose tablets, which is applied in the direction of drug combinations, medical preparations containing active ingredients, sugar-coated pills, etc., can solve the problems of difficult preparation and poor fluidity, and achieve low price and improved fluidity , Product quality is stable and controllable

Active Publication Date: 2012-07-04
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
View PDF1 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Methyl salicylate lactoside is one of the newly developed anti-inflammatory drugs, but there is no pharmaceutical formula or preparation containing methyl salicylate lactoside on the market, and because the active ingredient methyl salicylate lactoside is Amorphous powder, very poor fluidity, difficult to prepare various conventional dosage forms

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal composition and tablet containing salicylic acid methyl ester lactoside and preparation methods thereof
  • Medicinal composition and tablet containing salicylic acid methyl ester lactoside and preparation methods thereof
  • Medicinal composition and tablet containing salicylic acid methyl ester lactoside and preparation methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] This embodiment is used to illustrate the preparation method of the methyl salicylate lactose tablet provided by the present invention.

[0032] Tablet composition and dosage:

[0033]

[0034] Film coating composition and dosage:

[0035] Film-forming material:

[0036] Hypromellose 76g

[0037] Ethylcellulose 1.6g

[0038] Glyceryl Triacetate 1.6g

[0039] Coalescing aids:

[0040] Titanium dioxide 0.8g

[0041] Solvent:

[0042] 70% ethanol solution by volume 600mL

[0043] Preparation method: pass the above-mentioned amount of methyl salicylate lactoside, starch and sodium carboxymethyl starch through a 60-mesh sieve, and mix evenly; add starch slurry (1% by weight) to the granulator to granulate, and heat at 50°C Under the condition of vacuum drying for 3 hours, the water content of the granules is controlled between 1% and 2%. After sizing the granules with a 14 mesh sieve, the above-mentioned amount of magnesium stearate is added, and the tablets conta...

Embodiment 2

[0045] This embodiment is used to illustrate the preparation method of the methyl salicylate lactose tablet provided by the present invention.

[0046] Tablet composition and dosage:

[0047]

[0048] Film coating composition and dosage:

[0049] Film-forming material:

[0050] Hypromellose 47.5g

[0051] Ethyl cellulose 1g

[0052] Triacetin 1g

[0053] Coalescing aids:

[0054] Titanium dioxide 0.5g

[0055] Solvent:

[0056] 80% ethanol solution by volume 1000mL

[0057] Preparation method: pass the above-mentioned amount of methyl salicylate lactoside, cyclodextrin and crospovidone through a 60-mesh sieve, mix evenly; add polyvinylpyrrolidone K to the granulator 30 Ethanol solution (weight concentration 10%) is granulated, vacuum-dried at 60°C for 3 hours, and the water content of the granules is controlled between 1 and 2%. After sizing the granules with a 20-mesh sieve, add the above-mentioned amount of talcum powder, and press on a tablet machine. Methyl salic...

Embodiment 3

[0059] This embodiment is used to illustrate the preparation method of the methyl salicylate lactose tablet provided by the present invention.

[0060] Tablet composition and dosage:

[0061]

[0062] Film coating composition and dosage:

[0063] Film-forming material:

[0064] Hypromellose 58.2g

[0065] Ethylcellulose 0.9g

[0066] Glyceryl Triacetate 0.9g

[0067] Solvent:

[0068] Absolute ethanol 1000mL

[0069] Preparation method: pass the above-mentioned amount of methyl salicylate lactoside, microcrystalline cellulose and crospovidone respectively through a 60-mesh sieve, mix well, add 60mL of water as a binder, and stir evenly to make a soft material , placed in a wet granulator to make wet granules, dried in a vacuum drying oven at 75°C, controlling the moisture content of the granules between 1-2%, and adding the above-mentioned amount of stearic acid and The dry granules were mixed evenly, and the methyl salicylate lactoside tablets were obtained by compr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a medicinal composition containing salicylic acid methyl ester lactoside. The medicinal composition comprises the following raw materials in parts by weight: 100 parts of salicylic acid methyl ester lactoside, 20-300 parts of a thinner, 1-8 parts of a disintegrating agent, 20-400 part of a bonding agent and 0.5-6 parts of a lubricating agent. The invention further discloses a salicylic acid methyl ester lactoside tablet, which consists of a tablet core and a film coating uniformly coated on the surface of the tablet core, wherein the tablet core consists of the medicinal composition containing the salicylic acid methyl ester lactoside; and the film coating comprises the following raw materials in parts by weight: 20-200 parts of a film forming material, 0-50 parts of a film forming aid and 600-2,000 parts of a solvent. The invention further discloses a preparation method of the tablet. The medicinal composition provided by the invention is convenient to take, and has low toxic and side effects; the dissolution rate of the tablet is high, and the stability is high; and the preparation methods are easy to operate, and the prepared products have stable and controllable quality.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparation, and in particular relates to a pharmaceutical composition containing methyl salicylate lactoside, a tablet and a preparation method thereof. Background technique [0002] NSAIDs (Nonsteroidal Antiinflammatory Drugs, NSAIDs) are a class of anti-inflammatory drugs that do not contain a steroidal structure. Since aspirin was first synthesized in 1898, more than 100 brands of NSAIDs have been on the market for more than 100 years. Such drugs include aspirin, acetaminophen, indomethacin, naproxen, naproxen, diclofenac, ibuprofen, nimesulide, rofecoxib, celecoxib, etc. Anti-inflammatory, anti-rheumatic, analgesic, antipyretic and anti-coagulant effects are widely used clinically to relieve osteoarthritis, rheumatoid arthritis, various fevers and various pain symptoms. At present, NSAIDs are one of the most used drugs in the world, and about 30 million people in the wor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61K9/28A61P29/00
Inventor 何秀峰夏鹏飞王爱国刘冬孙宇张天泰杜冠华
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com