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Liquid preparation for rhinitis/allergic rhinitis as well as preparation method and application thereof

A technology for allergic rhinitis and liquid preparations, applied in allergic diseases, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve problems such as large side effects, unsatisfactory effects of rhinitis/allergic rhinitis, etc., and achieve fast onset , The product quality is stable and controllable, and the effect of no toxic and side effects

Active Publication Date: 2013-09-04
XINJIANG INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a liquid preparation for rhinitis / allergic rhinitis and its preparation method and application, which overcomes the above-mentioned deficiencies in the prior art, and can effectively solve the current The curative effect of western medicine on rhinitis / allergic rhinitis is not satisfactory and the side effects are large

Method used

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  • Liquid preparation for rhinitis/allergic rhinitis as well as preparation method and application thereof
  • Liquid preparation for rhinitis/allergic rhinitis as well as preparation method and application thereof
  • Liquid preparation for rhinitis/allergic rhinitis as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1, the liquid preparation for rhinitis / allergic rhinitis, every 100ml of the liquid preparation for rhinitis / allergic rhinitis contains 10g to 20g of Scutellaria baicalensis extract, 10g to 20g of Artemisia annua extract, 5g to 11g of licorice extract, 1g to 7g of solvent, 0.5g to 3.5g of thickener, 0.02g to 0.20g of preservative and the rest of water for injection; wherein, the liquid preparation for rhinitis / allergic rhinitis is obtained by the following preparation method: the rest of Water for injection includes water for primary injection and water for secondary injection. First, dissolve the required amount of solubilizer and thickener into water for primary injection respectively to obtain a solubilizer solution and a thickener solution. After the solution is dissolved, it is centrifuged, and the supernatant is taken, and the Scutellaria baicalensis extract is added to the supernatant to completely dissolve the Scutellaria baicalensis extract, then a thi...

Embodiment 2

[0049] Example 2, the liquid preparation for rhinitis / allergic rhinitis contains 10 g or 20 g of Scutellaria baicalensis extract, 10 g or 20 g of Artemisia annua extract, 5 g or 11 g of licorice extract, 1 g or 7 g of solvent, 0.5 g or 3.5 g of thickener, 0.02 g or 0.20 g of preservative and the remainder of water for injection; wherein, the liquid preparation for rhinitis / allergic rhinitis is obtained by the following preparation method: the remainder of Water for injection includes water for primary injection and water for secondary injection. First, dissolve the required amount of solubilizer and thickener into water for primary injection respectively to obtain a solubilizer solution and a thickener solution. After the solution is dissolved, it is centrifuged, and the supernatant is taken, and the Scutellaria baicalensis extract is added to the supernatant to completely dissolve the Scutellaria baicalensis extract, then a thickener solution is added therein and mixed evenl...

Embodiment 3

[0050] Embodiment 3, as the preferred embodiment of the above, Artemisia argyi extract is obtained according to the following preparation method: by adding ethanol aqueous solution to the Artemisia argyi medicinal material and carrying out alcohol extraction 1 to 5 times, each alcohol extraction is carried out by one gram Artemisia medicinal material 6ml to 14ml of ethanol aqueous solution with a mass concentration of 30% to 95% is added to Artemisia annua medicinal material, the time of each alcohol extraction is 0.5 hours to 3 hours, and the temperature of alcohol extraction is 60°C to 80°C. Combine the alcohol extraction solutions obtained each time to obtain the alcohol extraction solution, and then volatilize the alcohol extraction solution with ethanol. Drying under reduced pressure to obtain Artemisia annua extract with a water mass content of 5% to 20%.

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Abstract

The invention relates to the technical field of liquid traditional Chinese medicine preparations and provides a liquid preparation for rhinitis / allergic rhinitis as well as a preparation method and application thereof. The liquid preparation is obtained by virtue of the following method: carrying out centrifugation after dissolving Artemisia rupetris extracts in a solubilizer solution, taking the supernatant, adding Scutellaria baicalensis extracts to the supernatant and completely dissolving the Scutellaria baicalensis extracts; then adding a thickener solution to the solution, mixing the solutions uniformly, then adding liquorice extracts to the mixture, stirring the mixture to dissolve the liquorice extracts, then adding a preservative to the solution, and fully stirring the solution to dissolve the preservative; and finally adding water for injection to the solution and mixing the substances uniformly, thus obtaining the liquid preparation for rhinitis / allergic rhinitis. The liquid preparation is simple in process, has stable and controllable quality, obvious curative effects and no toxic or side effect, directly acts on the surface of nasal mucosa, has high bioavailability, takes effect quickly, is convenient to use and has good patient compliance.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine liquid preparations, and relates to a liquid preparation for rhinitis / allergic rhinitis, a preparation method and application thereof. Background technique [0002] Allergic rhinitis is a common allergic disease. It is a chronic nasal mucosal inflammation characterized by recurrent sneezing, watery runny nose, and nasal congestion. The disease often causes adverse effects such as decreased sleep quality, emotional irritability, depression, etc., which limits daily activities and social communication. If drug reactions or various complications (sinusitis, nasal polyps, otitis media, asthma, etc.) occur in allergic rhinitis, it will be even worse. Due to the anatomical continuity of the upper respiratory tract and the lower respiratory tract, upper respiratory tract inflammation can easily spread downward, and many patients often suffer from allergic rhinitis and bronchial a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539A61P37/08A61P11/02
Inventor 顾政一贺金华沙先谊戎晓娟董先红杨国萍
Owner XINJIANG INST OF MATERIA MEDICA
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