Arthralgia relieving gel and preparation method thereof

A joint and gel technology, applied in the field of medicine, can solve the problems that hinder the clinical application of joint pain relief ointment, the volatile loss of volatile oil components, strong skin irritation and allergy, etc., to reduce skin irritation and allergy, easy to wash with water Effects of removing and improving compliance

Inactive Publication Date: 2014-09-03
ANHUI ANKE YULIANGQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the joint pain relief ointment is a rubber ointment, which uses natural rubber as the skeleton material and rosin as the tackifier. These materials have strong irritation and allergies to the skin, excessive adhesion, poor air permeability, and poor patient compliance. Thereby hindering the clinical application of joint pain relief ointment, in addition, because the joint pain relief ointment is applied to the joints where the patient often moves, not only the comfort is low when the patient is active, but also the joint pain relief ointment is easy to wrinkle, resulting in

Method used

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  • Arthralgia relieving gel and preparation method thereof
  • Arthralgia relieving gel and preparation method thereof
  • Arthralgia relieving gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of Joint Pain Relief Gel

[0030] 1) take capsicum, pulverize into coarse powder, add 1 times mass fraction to the capsicum coarse powder and be 85% ethanol (that is to say the mass addition of ethanol is 1 times of capsicum coarse powder), soak for 2 days, Percolating, collecting and filtering the percolation liquid, then concentrating the filtrate under reduced pressure at 30°C to a relative density of 1.30g / ml to obtain capsicum fluid extract;

[0031] 2) Weighing belladonna, crushing it into belladonna coarse powder, adding 2 times the mass fraction of 85% ethanol to the belladonna coarse powder, soaking for 2 days, percolating, collecting the percolating liquid and filtering, Recover ethanol under reduced pressure, cool naturally to room temperature, separate and remove chlorophyll, filter, concentrate the filtrate under reduced pressure to a thick shape, then add 10 times the mass fraction of 85% ethanol for precipitation, absorb the superna...

Embodiment 2

[0037] Example 2: Preparation of Joint Pain Relief Gel

[0038] 1) Weigh the pepper, crush it into coarse powder, add 3 times of ethanol with a mass fraction of 85% to the pepper coarse powder, soak for 3 days, percolate, collect the percolation liquid and filter, and then put The filtrate was concentrated under reduced pressure to a relative density of 1.30 g / ml to obtain capsicum liquid extract;

[0039] 2) Take belladonna, crush it into belladonna coarse powder, add 3 times the mass fraction of 85% ethanol to the belladonna coarse powder, soak for 3 days, percolate, collect the percolation liquid and filter, Recover ethanol under reduced pressure, cool naturally to room temperature, separate and remove chlorophyll, filter, concentrate the filtrate under reduced pressure to a thick shape, then add 10 times the mass fraction of 85% ethanol for precipitation, absorb the supernatant, and store at 30°C Concentrate the supernatant under reduced pressure to a thick paste with a r...

Embodiment 3

[0045] Example 3: Preparation of Joint Pain Relief Gel

[0046] 1) Weigh the pepper, crush it into coarse powder, add 1.5 times of ethanol with a mass fraction of 90% to the pepper coarse powder, soak for 2 days, percolate, collect the percolation liquid and filter, and then put the The filtrate was concentrated under reduced pressure to a relative density of 1.27g / ml to obtain capsicum liquid extract;

[0047] 2) Weigh belladonna, crush it into belladonna coarse powder, add 1.5 times of ethanol with a mass fraction of 90% to the belladonna coarse powder, soak for 2 days, percolate, collect percolation and filter, Recover ethanol under reduced pressure, cool naturally to room temperature, separate and remove chlorophyll, filter, concentrate the filtrate under reduced pressure to a thick shape, then add 10 times the mass fraction of 85% ethanol for precipitation, absorb the supernatant, and store at 25°C Concentrating the supernatant under reduced pressure to a thick paste wit...

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Abstract

The invention relates to the medicine field and specifically discloses an arthralgia relieving gel. The arthralgia relieving gel is prepared from raw materials including the following components in parts by weight: 160-240 parts of capsicum fluid extract, 90-140 parts of atropa belladonna fluid extract, 30-50 parts of dementholized peppermint oil, 70-90 parts of methyl salicylate, 160-240 parts of camphor, 10-15 parts of diphenhydramine hydrochloride, 1-10 parts of triethanolamine, 2-30 parts of carbomer, 1-3 parts of ethylparaben, 3-40 parts of hydroxypropyl methylcellulose, 50-100 parts of glycerin, 1-10 parts of ethanol, 1-5 parts of azone and a proper quantity of water; all the raw material components are of 1000 parts in total. The invention also discloses a preparation method of the arthralgia relieving gel. Compared with the existing arthralgia relieving plaster in the prior art, the arthralgia relieving gel has the advantages of good stability, easy absorption, remarkable medical effect, low skin irritation and safe production.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine for joint pain relief and a preparation method thereof. Background technique [0002] The traditional Joint Zhitong Ointment is a Chinese patent medicine, which has the functions of promoting blood circulation, dispelling blood stasis, warming the meridian and relieving pain. It is clinically used to treat rheumatic arthralgia and joint sprains caused by cold-damp stasis blocking the meridian, and the curative effect is remarkable. But the joint pain relief ointment is a rubber ointment, which uses natural rubber as the skeleton material and rosin as the tackifier. These materials have strong irritation and allergies to the skin, excessive adhesion, poor air permeability, and poor patient compliance. Thereby hindering the clinical application of joint analgesic ointment, in addition, because joint analgesic ointment is to stick to the joint position that the...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K9/06A61P29/00A61P19/02
Inventor 刘道芳刘海兵谢红星田湘玲徐莉莉廖华宁
Owner ANHUI ANKE YULIANGQING PHARMA
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