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Coptis chinensis and donkey-hide gelatin composition for treating sicca syndrome and application of coptis chinensis and donkey-hide gelatin composition

A technology for Sjögren's syndrome and a composition is applied in the field of Coptis Ejiao composition for treating Sjögren's syndrome, and can solve the problems of limiting the clinical curative effect of Sjögren's syndrome, limiting the unification of disease cognition and thinking, and the actual curative effect is not very clear. Achieve the effect of improving mental state and immune function, satisfying clinical effect, and safe clinical use

Active Publication Date: 2015-06-03
SHAN DONG DONG E E JIAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of traditional Chinese medicine to treat Sjögren's syndrome has achieved certain curative effects. However, in the process of clinical diagnosis and treatment, most modern doctors are mostly limited to clinical observation and experience introduction. The diagnosis and treatment standards are very random, and the actual curative effect is not very clear. Clinicians It is limited to the individual understanding of the disease, which greatly limits the clinical curative effect of Sjogren's syndrome, and also limits the unity of understanding and thinking of the disease itself; currently there is no traditional Chinese medicine preparation for the treatment of Sjogren's syndrome with a more accurate curative effect on the market listing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Preparation of capsules

[0033] (1) Weigh the raw materials according to the following weights: Rhizoma Coptidis 800g, Ejiao 900g, White Peony Root 600g, Scutellaria baicalensis Georgi, 300g Sour date kernels

[0034] 600g, cinnamon 200g, albizia bark 600g;

[0035] (2) Extract the volatile oil from cinnamon, encapsulate the volatile oil and smash it for later use;

[0036] (3) Extract the cinnamon residue from the volatile oil together with Scutellaria baicalensis Georgi and Albizia Julibrissin with water for two times. Add water twice the weight for the first time and cook for 3 hours. Add water 4 times the weight for the second time and cook for 1 hour; Combine the cooking liquor, filter, and concentrate the filtrate to a relative density of 1.30 to 1.35 (55°C) to clear the cream; combine the two clear creams, spray dry, and set aside;

[0037] (4) Extract Rhizoma Coptidis, Radix Paeoniae Alba and Jujube Seed with 85% ethanol, and spray dry the extract for use;

[...

Embodiment 2

[0039] Example 2: Preparation of capsules

[0040] Prescription composition:

[0041] Coptis 280g Ejiao 315g White Peony 210g Scutellariae 105g

[0042] Jujube seed (fried) 210g cinnamon 70g albizia peel 210g

[0043] Preparation Process:

[0044] (1) Rhizoma Coptidis, Radix Paeoniae Rubra, Jujube Seed with 70% ethanol 6 times the amount of extraction 3 times, 1.5 hours each time, filtered, the filtrate recovered ethanol, concentrated to a relative density of 1.08 ~ 1.10 (60 ℃), spray dried Fine powder for later use;

[0045] (2) Add 12 times the amount of cinnamon to water. After soaking for 3 hours, extract the volatile oil for 3.5 hours. The volatile oil and the water extract are separately stored for later use, and the medicine residue is stored separately for later use. Take cinnamon volatile oil and add 10 times the amount of β-cyclodextrin and then add β-ring After mixing 3 times the amount of dextrin with 20% ethanol, grind it with a colloid mill for 15 minutes and refrigerate...

Embodiment 3

[0048] Example 3: Preparation of powder

[0049] Weigh the raw materials according to the following weights: Coptis 600g, donkey-hide gelatin 700g, white peony 400g, scutellaria 100g, jujube seed 400g, cinnamon 50g, and Albizia julibrissin 400g; the above-mentioned raw materials are crushed and passed through an 80-mesh sieve.

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Abstract

The invention discloses a coptis chinensis and donkey-hide gelatin composition for treating sicca syndrome and an application of the coptis chinensis and donkey-hide gelatin composition, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials: coptis chinensis, donkey-hide glue, white paeony root, scutellaria baicalensis, spina date seeds, cinnamon and cortex albiziae. The prescription has the efficacies of nourishing yin, moistening dryness, clearing away heat and toxic materials, activating blood circulation and removing stasis, meanwhile, the treatment effect on a sjogren syndrome is relatively obvious; the recovery rate is 62.9%; the total effective rate is 95.2%; and the coptis chinensis and donkey-hide gelatin composition has the characteristics of being good in curative effect, short in treatment course, free of a side effect and the like. The traditional Chinese medicine composition disclosed by the invention is safe in clinical application, and free of adverse reaction after being used by patients, and is capable of effectively improving the mental state and the immune function of the patients; and no dependent reaction is generated after the medicine disclosed by the invention is stopped.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a composition of coptis donkey-hide gelatin for treating Sjögren's syndrome and its application. Background technique [0002] Sjögren's syndrome (Sjogren Syndrome, SS) is a chronic autoimmune disease that invades exocrine glands, especially salivary glands and lacrimal glands. Its immune inflammatory response is mainly manifested in the epithelial cells of exocrine glands, so it is also called Autoimmune exocrine gland epithelial cell inflammation or autoimmune exocrine disease. The main clinical manifestations are keratoconjunctivitis sicca, xerostomia, and other important internal organs such as lung, liver, pancreas, kidney, blood system, and nerve complex clinical manifestations. The onset of this disease is often hidden, and the clinical manifestations are diverse. The main manifestations are related to glandular dysfunction. In recent years...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61P37/02A61K35/36
Inventor 张淹周祥山田守生王春艳李士栋
Owner SHAN DONG DONG E E JIAO
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