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116 results about "Autoimmune liver disease" patented technology

Autoimmune hepatitis, formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed.

Kit for joint or single detection of autoimmune liver disease related antibody and detection method of kit

InactiveCN102707055AEarly Diagnosis GuaranteeEarly Treatment BenefitMaterial analysisAntigenLiver disease
The invention discloses a kit for joint or single detection of an autoimmune liver disease related antibody, and a method for quantitative and qualitative detection of the autoimmune liver disease related antibody by using the kit. A sample is combined with a specific antigen which is connected with IgG or / and anti-human IgM or / and anti-human IgA of a label and corresponds to a detection antibody, a substrate of a luminescent system or a color development system or an exciting light system is added, then the signal value of the sample to be tested is read, and a quantitative or qualitative result is calculated or the quantitative or qualitative result is read through an immuno-chromatographic or an immuno-percolation method naked eye or an instrument, so that the type and the severity of an autoimmune liver disease are accurately diagnosed, medication performed by doctors is guided, and the method is high in sensitivity, strong in specificity and high in accuracy, and is suitable for a semi-automatic or full-automatic detection system or naked eye interpretation.
Owner:AUTOBIO DIAGNOSTICS CO LTD

Azathioprine Oral Suspensions and Methods of Use

Compositions of azathioprine oral suspensions are disclosed. Disclosed azathioprine oral suspensions may be used to administer azathioprine to subjects such as children and geriatric patients that may have difficulty in swallowing solid dosage forms. The disclosed azathioprine oral suspension may be used for treating autoimmune diseases such as rheumatoid arthritis, pemphigus, Behcet's disease, autoimmune hepatitis, and inflammatory bowel disease, among others. According to an embodiment, an aqueous or non-aqueous vehicle may be used for azathioprine oral suspension. According to a different embodiment, sugar free azathioprine oral suspension may also be produced.
Owner:PROFESSIONAL COMPOUNDING CENTS OF AMERICA PCCA

Novel death receptor 5 antibody fusion protein and application thereof

The invention relates to sDR5-Fc recombinant protein (ZJ501-5) with an amino acid sequence shown as SEQ ID NO: 2 and a gene shown as SEQ ID NO: 1 of the recombinant protein, and meanwhile, the invention discloses an application of the sDR5-Fc recombinant protein and the gene thereof in preparing medicines for treating immune liver diseases. In addition, bioactivity of the sDR5-Fc protein in vitro is 3 times higher than that of an sDR5-Fc product from R&D systems Company, the proportion of an N terminal splice variant is just about 1% and the sDR5-Fc protein is high in protein drug stability; and the sDR5-Fc protein provided by the invention, which can significantly improve a survival rate of mice having Con A induced acute autoimmune hepatitis, has a potential application value for treating autoimmune hepatitis in human being.
Owner:SHENZHEN ZHONGKE AMSHENN MEDICINE CO LTD

Polyazanaphthalene compounds and pharmaceutical use thereof

The present invention relates to an inhibitor of matrix metalloprotease (MMP) production and tumor necrosis factor (TNF) production, and medicines for the treatment of diseases such as chronic rheumatoid arthritis, osteoarthritis, allergic diseases, psoriasis, transplant rejection, arterial sclerosis, ischemic re-perfusion disorder, diabetic nephritic and ocular diseases, cancer, autoimmune glomerulonephritis, infectious diseases, Crohn's disease, inflammatory intestinal diseases and autoimmune hepatitis, each comprising certain polyazanaphthalene compounds or pharmaceutically acceptable salts thereof as active ingredients.
Owner:AJINOMOTO CO INC

Traditional Chinese medicine preparation for treating autoimmune hepatitis

InactiveCN105055738AHave the effect of regulating immunityIncrease the burdenDigestive systemImmunological disordersPinelliaGLYCYRRHIZA EXTRACT
The invention discloses a traditional Chinese medicine preparation for treating autoimmune hepatitis and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine preparation comprises the following components in parts by weight: 10-20 parts of rhizoma alismatis, 10-20 parts of pinellia ternate, 15-30 parts of astragalus membranaceus, 30-45 parts of capillary wormwood herb, 10-30 parts of rheum palmatum, 5-15 parts of Chinese thorowax root, 10-23 parts of rhizoma cimicifugae, 8-20 parts of polyporus umbellatus, 15-40 parts of white peony root, 8-15 parts of angelica sinensis, 16-28 parts of talc, 25-45 parts of poria cocos, 10-20 parts of liquorice, 10-20 parts of cassia twig and 30-50 parts of codonopsis pilosula. The traditional Chinese medicine preparation is obtained by decocting all components with water. According to the invention, different traditional Chinese medicines can be added according to different symptoms of the autoimmune hepatitis, and meanwhile, body nourishing and qi nourishing of patients are considered during treatment.
Owner:QINGDAO MUNICIPAL HOSPITAL

Total flavone extract of lonicera macranthoides leaves, and preparation method and application thereof

The invention provides an extraction method and application of total flavone extract from lonicera macranthoides leaves. The total flavone of lonicera macranthoides leaves is furthest extracted by adopting a water-extraction and alcohol precipitation process; and the flavone compound is selectively separated through macroporous resin, and is concentrated and dried to obtain the flavone compound with high purity. The process is simple, and is suitable for large-scale industrial production, and the total flavone content of the total flavone extract prepared from the lonicera macranthoides leaves is higher than 50 percent. The total flavone extract has excellent activity in treating autoimmune hepatitis, hyperglycemia and hyperlipidemia syndromes.
Owner:CHONGQING ACAD OF CHINESE MATERIA MEDICA

Kit for detecting autoimmune liver disease related antibody autoantibody to nuclear antigen (ANA) and detection method thereof

InactiveCN102955030AEarly Diagnosis GuaranteeEarly Treatment BenefitChemiluminescene/bioluminescenceAntigenSemi automatic
The invention discloses a kit for detecting an autoimmune liver disease related antibody autoantibody to nuclear antigen (ANA). The invention also discloses a method for quantitatively and qualitatively detecting ANA by using the kit. The method comprises the following steps of: combining a detection sample with a specific antigen which corresponds to a marker-linked anti-human IgG or / and anti-human IgM or / and anti-human IgA and a detection antibody, adding substrates of a luminous system or a developing system or a light exciting system, reading a signal value of a sample to be detected, calculating a quantitative and qualitative result, and reading the sample through immunochromatography or immuno-infiltration naked eyes or instruments to obtain a quantitative and qualitative result, thus accurately diagnosing the type of severity of the autoimmune liver disease, and guiding the medication of a doctor. The kit and the detection method have high sensitivity, high specificity and high accuracy and are suitable for semi-automatic or full-automatic detection systems or naked eye interpretation.
Owner:AUTOBIO DIAGNOSTICS CO LTD

Pharmaceutical use of wedelolactone and its derivative

The invention relates to medical applications of wedelolactone and derivatives thereof, in particular to the applications in preparing medicines for treating T-cell mediated immunologic injury diseases (chronic hepatitis or autoimmune hepatitis). Traditional Chinese Medicine eclipta has a function of liver protection; wedelolactone is prepared after the active ingredient of eclipta is traced and separated, so the pharmaceutical function is proved to be produced by wedelolactone; the structure of wedelolactone is determined through the spectrum properties and physicochemical properties. Wedelolactone is provided with biological activities: high selective inhibition to ConA stimulated T lymphocyte proliferation, no inhibition to normal peripheral blood lymphocyte (NPBL), and no cytotoxicity; wedelolactone is the active ingredient of Traditional Chinese Medicine with liver protection function; the method for preparing a novel medicine from the active ingredient of eclipta, wedelolactone, has the advantages of discarding the dross and selecting the essential, clear medicinal ingredients, definite function, safety and effectiveness, controllable quality, reducing the adverse drug reaction, and can be suitable for mass production.
Owner:SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE

Traditional Chinese medicine for regulating liver regeneration and prevention and treatment method by using same

The invention discloses a compound composition of traditional Chinese medicine granules for regulating liver regeneration and prevention and treatment methods for chronic liver diseases by using the compound alone or in combination with antiviral medicine. The medicine is composed of: 5-30 parts of prepared Chinese foxglove root, 5-30 parts of virgate wormwood, 3-9 parts of turmeric, 3-12 parts of licorice, 3-15 parts of schisandra fruit, 5-15 parts of underleaf pearl, 5-30 parts of diffusa , 5-30 parts of poria, 5-30 parts of coix seed, 5-30 parts of salvia fruit, 1-10 parts of curcuma rhizome, 3-12 parts of dodder, and 5-15 parts of mistletoe For people suffering from chronic liver diseases (drug-induced liver disease, alcoholic or non-alcoholic fatty liver disease, autoimmune liver disease, viral hepatitis, etc.) which have high risk of liver failure, liver cirrhosis, and liver cancer, and people suffering from liver cancer or people after liver cancer surgery, clinical and experimental evidences show that the traditional Chinese medicine granules have synergies of regulation of liver regeneration and anti-virus, anti-liver injury, anti-liver fibrosis, and liver cancer prevention, and a relatively high level of clinical evidence based medicine evidences are obtained.
Owner:李瀚旻

Chinese medicine composition for treating autoimmune liver disease, and preparation method thereof

The invention discloses a Chinese medicine composition for treating an autoimmune liver disease. The Chinese medicine composition is prepared from the Chinese medicinal materials, namely rheum officinale, radix rubiae, fructus forsythia, herba siegesbeckiae, large-leaved gentian and liquorice. The invention also discloses a preparation method of the Chinese medicine composition and application of the Chinese medicine composition. The composition has the effects of clearing away heat and toxic materials, smoothing liver-gallbladder, and promoting blood circulation to remove blood stasis, and is mainly used for treating autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis.
Owner:THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL

Application of compound HUBIN-1 in preparation of drug for preventing and/or treating liver inflammatory diseases

The invention relates to the field of drug research and development and particularly discloses an application of a compound HUBIN-1 in preparation of a drug for preventing and / or treating liver inflammatory diseases. Extensive and deep research discovers the hepatocyte protection function and the anti-inflammatory treatment function of the compound HUBIN-1 for the first time, the compound HUBIN-1 is applicable to various types of liver inflammations, and the application field of the compound HUBIN-1 is broadened. The novel drug for preventing and / or treating various liver inflammatory diseases such as acute hepatitis, chronic hepatitis and severe hepatitis (hepatic failure) which include viral hepatitis, drug-induced hepatitis, nonalcoholic fatty liver disease, alcoholic hepatitis, autoimmune hepatitis and the like is provided and has remarkable social benefits.
Owner:ZHEJIANG UNIV

Antagonists of CB1 Receptor

The invention relates to an antagonist of CB1 receptor for use in the treatment of a pathologic condition or disorder selected from the group consisting of bladder and gastrointestinal disorders; inflammatory diseases; cardiovascular diseases; nephropathies; glaucoma; spasticity; cancer; osteoporosis; metabolic disorders; obesity; addiction, dependence, abuse and relapse related disorders; psychiatric and neurological disorders; neurodegenerative disorders; autoimmune hepatitis and encephalitis; pain; reproductive disorders and skin inflammatory and fibrotic diseases.
Owner:UNIV DE BORDEAUX +1

Kit for detecting relevant autoantibody spectrum of autoimmune liver disease

InactiveCN104459159AOriginalityPlay the role of interpretationBiological testingAntigenNitrocellulose
The invention discloses a kit for detecting the relevant autoantibody spectrum of an autoimmune liver disease, and belongs to the technical field of biology. The kit comprises a membrane strip, an enzyme label liquid, a substrate and an enzyme label incubation buffer liquid, wherein the membrane strip is composed of a fixed plate as well as an antigen strip, a critical quality control strip and a functional quality control line which are sequentially fixed on a nitrocellulose membrane, wherein the antigen strip is formed by drawing 8 or 6 mutually independent drawing lines in AMA-M2, LKM-1, LC-1, SLA, F-action, gp210, Sp100 and La / SS-B on the nitrocellulose membrane. The kit can be used for detecting 8 relevant antibodies of the autoimmune liver disease, and can act as a basis for auxiliary diagnosis. The additionally arranged La / SS-B strip can be used for differentiating the autoimmune liver disease and liver injury caused by sicca syndrome, and thus providing a basis for the correct dosage regimen.
Owner:GUANGZHOU NATI BIOTECH CO LTD

Preparation method of membrane strip of kit for detecting autoantibody spectrum related to autoimmune liver disease (AILD) and kit composed of same

ActiveCN102937650AOriginalityPlay the role of interpretationMaterial analysisAntigenMicrobiology
The invention relates to a preparation method of a membrane strip of a kit for detecting autoantibody spectrum related to an AILD and the kit composed of the same. According to the preparation method of the membrane strip and the kit, the membrane strip is composed of a carrier piece and an antigen band, a critical quality control band and a functional quality control line which are sequentially fixed on the carrier piece. The antigen band is formed by at least two of AMA-M2, LKM-1, LC-1, SLA, F-actin, gp210 and Sp100 through independent marking to a nitrocellulose membrane or a nylon membrane. The ingenious critical quality control band is provided, one critical quality control band can play a role in interpreting two or even more detection bands (antigen bands), and result determination is simpler and more reliable.
Owner:SICHUAN XINCHENG BIOLOGICAL CO LTD

Intestinal microbial marker for distinguishing autoimmune hepatitis patients from healthy people and applications of intestinal microbial marker

The invention belongs to the technical field of biomedicine, and specifically relates to an intestinal microbial marker for distinguishing autoimmune hepatitis patients from healthy people and applications of the intestinal microbial marker. The intestinal microbial marker for distinguishing the autoimmune hepatitis patients from the healthy people provided by the invention is composed of microorganisms indicated by at least one gene shown in SEQ ID NO:1-5, and the microbial genes are obviously enriched or reduced in human intestines. The invention also provides an application of a detection reagent to preparation of a detection kit for distinguishing the autoimmune hepatitis patients from the healthy people, and an application of the detection reagent to establishing of an intestinal microbial model for distinguishing the autoimmune hepatitis patients from the healthy people. Therefore, the microbial gene distinguishing model provided by the invention realizes good distinguishing ability in the autoimmune hepatitis patients and the healthy people.
Owner:THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV

Use of arctigenin in preparing medicine for treating autoimmune hepatitis

The invention provides a use of arctigenin in preparing a medicine for treating autoimmune liver diseases, and belongs to the field of medicine. Arctigenin is an effective traditional Chinese medicine monomer obtained by extracting from a traditional Chinese medicine fructus arctii; when being used in treatment of the autoimmune liver diseases, arctigenin can significantly improve the proportion of immune cell factors of a patient, significantly reduces the aminotransferase level and the liver index of the patient, thereby playing effects of simultaneous treatment of principal and subordinate symptoms on the autoimmune liver diseases especially autoimmune hepatitis. Arctigenin has small toxic and side effect in a drug use process, and is definite in therapeutic effect, low in price and quite wide in medical application prospects.
Owner:LUNAN PHARMA GROUP CORPORATION

Traditional Chinese medicine composition for treating autoimmune hepatitis and preparation method of traditional Chinese medicine composition

The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for treating autoimmune hepatitis, and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine components in parts by weight: 45-60 parts of rhizoma alismatis, 5.5-7 parts of radix gentianae, 30-40 parts of tripterygium wilfordii hook. f, 25-30 parts of herba scutellariae barbatae, 30-35 parts of herba epimedii, 85-90 parts of radix et caulis acanthopanacis senticosi, 15-20 parts of herba hedyotis, 12-15 parts of radix puerariae, 5-10 parts of rhizoma corydalis, 9-15 parts of folium nelumbinis, 10-15 parts of radix astragali seu hedysari, 6-9 parts of rhizoma curculigins, 10-15 parts of radix glycyrrhizae. The traditional Chinese medicine composition is superior to the existing therapeutic drugs on the aspect of treating autoimmune hepatitis, and thus the traditional Chinese medicine composition is suitable for clinical popularization and use.
Owner:邹士东

Coumarether compound and use of its composition

InactiveCN101225087AModulating immunityHas the effect of regulating immunityOrganic active ingredientsOrganic chemistryMedicineEther
The invention discloses a coumaric grass ethers extracted from compositae plants, or a salt or an ester accepted in pharmacy, or the application of the plant extracts of the compound for the preparation of medicine for curing autoimmune liver disease and viral hepatitis. As shown by the vitro and vivo experiments to the animal body, the coumaric grass ethers extracted from compositae plants, or a salt or an ester accepted in pharmacy has the advantages of effective therapy and improvement of the symptoms of autoimmune liver disease and viral hepatitis.
Owner:XIANGBEI WELMAN PHARMA CO LTD

Pregnane glycoside compounds with orthoester groups and applications thereof

ActiveCN102532229ASignificant in vitro immunosuppressive activityPrevent proliferationOrganic active ingredientsDigestive systemDiseaseOrthoester
The invention relates to pregnane glycoside compounds with orthoester groups, medical compositions with the compounds and applications of the medical compositions in the preparation of immunosuppressive agents, and in particular relates to pregnane glycoside compounds which are extracted from Periploca plants and contain the orthoester groups, medical compositions with the compounds, and applications of the medical compositions in the preparation of the immunosuppressive agents which are used to prevent and / or treat immunological rejection after cell / organ transplantation, or autoimmune diseases which contain rheumatoid arthritis, multiple sclerosis, autoimmune hepatitis, etc.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI

Antagonists of CB1 Receptor

The invention relates to an antagonist of CB1 receptor for use in the treatment of a pathologic condition or disorder selected from the group consisting of bladder and gastrointestinal disorders; inflammatory diseases; cardiovascular diseases; nephropathies; glaucoma; spasticity; cancer; osteoporosis; metabolic disorders; obesity; addiction, dependence, abuse and relapse related disorders; psychiatric and neurological disorders; neurodegenerative disorders; autoimmune hepatitis and encephalitis; pain; reproductive disorders and skin inflammatory and fibrotic diseases.
Owner:UNIV DE BORDEAUX +1

Methods and Compositions for Diagnosis of Inflammatory Liver Disease

The present disclosure provides methods and compositions that find use in facilitating a diagnosis of inflammatory liver disease in a subject. The methods and compositions generally involve detection of eotaxin-3 (E3) levels, either alone or with levels of eotaxin-1 (E1), and optionally, with levels of CCL22 and, further optionally, with levels of IL15. These levels can be used to facilitate a diagnosis of a liver disease of at least one of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), and / or to facilitate a differential diagnosis between AIH, PBC, and PSC. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject.
Owner:MEDIZINISCHE HOCHSCHULE HANNOVER +1

Kit for detecting LC-1 antibody relative to autoimmune liver diseases, and detection method with kit

The invention discloses a kit for detecting LC-1 antibody relative to autoimmune liver diseases, and a quantitative and quantitative detection method for the LC-1 antibody with the kit. The detection method comprises the following steps of: combining a sample with IgG or / and anti-human IgM or / and anti-human IgA, which is / are connected with marker(s), and specific antigen corresponding to the detected antibody; adding a substrate of a luminescence system or a developing system or a light exciting system into the sample, and then reading a signal value of the sample to be detected; and calculating a quantitative and quantitative result or reading a quantitative and quantitative result of the sample by naked eyes or instruments according to immunochromatography or immuno-infiltration, thereby accurately diagnosing the type and severity of the autoimmune liver diseases to guide a doctor to dispense medicines. The quantitative and quantitative detection method has the advantages of high sensitivity, strong specificity and high accuracy, and is applicable to interpretation by semi-automatic or full-automatic detection systems or naked eyes.
Owner:AUTOBIO DIAGNOSTICS CO LTD

Application of rosemary compound in drug for preventing and treating autoimmune hepatitis

The invention provides an application of a rosemary compound in a drug for preventing and treating autoimmune hepatitis. The rosemary compound can significantly reduce ConA-induced hepatitis / liver injury, and inhibit the production of inflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin 6(IL-6), interferon-gamma(IFN-gamma) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), by reducing serum transaminase ALT / AST level, play an anti-inflammatory role and relieves hepatitis / liver injury. The invention also provides a drug for preventing and treating autoimmune hepatitis, which comprises the rosemary compound.
Owner:江西华普康明生物科技有限公司

Immunotherapy and prevention of autoimmune hepatitis

InactiveUS20100310656A1Increase attractivenessInferior in their clinical efficacyBiocidePowder deliveryDiseaseAutoimmune responses
The invention is within the field of immunology and microbiology, more specifically the field of virology and is related to immunotherapy and prophylaxis of hepatitis and autoimmune diseases. The composition useful for these purposes is disclosed, including the methods of making and using said composition.
Owner:IMMUNITOR USA

Autoimmune hepatitis risk prediction model and construction method thereof

The invention provides an autoimmune hepatitis risk prediction model and a construction method thereof. According to the construction method, noninvasive clinical data are collected and multi-factor logistic regression analysis is performed by selecting and classifying unknown-cause liver damage cases to obtain risk factors and decision coefficients of AIH, and a logistic regression model for predicting the autoimmune hepatitis risk is obtained, or an autoimmune hepatitis risk prediction nomogram model is established by the logistic regression. The autoimmune hepatitis risk prediction model provided by the invention can be used for early risk prediction of AIH of a patient with unknown-cause liver damage, has higher resolution, accuracy and clinical application value, is helpful for doctors to effectively persuade the patient with unknown-cause liver damage to receive the suggestion of liver biopsy as soon as possible, and enables the real patient with autoimmune hepatitis to be diagnosed and treated properly.
Owner:SHANGHAI SIXTH PEOPLES HOSPITAL

Kit for detecting AMA (anti-mitochondrial antibody)-M2 relative to autoimmune liver diseases, and detection method with kit

InactiveCN102955028AAccurate diagnosisChemiluminescene/bioluminescenceAnti-mitochondrial antibodyAntigen
The invention discloses a kit for detecting AMA (anti-mitochondrial antibody)-M2 relative to autoimmune liver diseases, and a quantitative and quantitative detection method for the AMA-M2 with the kit. The detection method comprises the following steps of: combining a sample with IgG or / and anti-human IgM or / and anti-human IgA, which is / are connected with marker(s), and specific antigen corresponding to the detected antibody; adding a substrate of a luminescence system or a developing system or a light exciting system into the sample, and then reading a signal value of the sample to be detected; and calculating a quantitative and quantitative result or reading a quantitative and quantitative result of the sample by naked eyes or instruments according to immunochromatography or immuno-infiltration, thereby accurately diagnosing the type and severity of the autoimmune liver diseases to guide a doctor to dispense medicines. The quantitative and quantitative detection method has the advantages of high sensitivity, strong specificity and high accuracy, and is applicable to interpretation by semi-automatic or full-automatic detection systems or naked eyes.
Owner:AUTOBIO DIAGNOSTICS CO LTD

Autoimmune hepatitis model and medicine screened by using autoimmune hepatitis model

The invention discloses an autoimmune hepatitis model and medicine screened by using the autoimmune hepatitis model. Firstly, an AAGL-induced AIH-like mouse hepatitis model is built; the model is notsensitive on the treatment of a conventional immunosuppressor, and can be clinically used as an animal model for conventional immunological suppression treatment on non-sensitive patients. The invention further provides the medicine screened by using the model for treating the autoimmune hepatitis. The result shows that glatiramer acetate can obviously relieve the autoimmune hepatitis symptom of the animal model. The condition indicates that the glatiramer acetate can be used for treating the autoimmune hepatitis. Therefore the invention provides a novel purpose of the glatiramer acetate. Novel medicine is provided for the treatment of the autoimmune hepatitis.
Owner:WUHAN UNIV

Kit for detecting LKM (anti-liver-kidney microsomal antibody)-1 relative to autoimmune liver diseases, and detection method with kit

The invention discloses a kit for detecting LKM (anti-liver-kidney microsomal antibody)-1 relative to autoimmune liver diseases, and a quantitative and quantitative detection method for the LC-1 antibody with the kit. The detection method comprises the following steps of: combining a sample with IgG or / and anti-human IgM or / and anti-human IgA, which is / are connected with marker(s), and specific antigen corresponding to the detected antibody; adding a substrate of a luminescence system or a developing system or a light exciting system into the sample, and then reading a signal value of the sample to be detected; and calculating a quantitative and quantitative result or reading a quantitative and quantitative result of the sample by naked eyes or instruments according to immunochromatography or immuno-infiltration, thereby accurately diagnosing the type and severity of the autoimmune liver diseases to guide a doctor to dispense medicines. The quantitative and quantitative detection method has the advantages of high sensitivity, strong specificity and high accuracy, and is applicable to interpretation by semi-automatic or full-automatic detection systems or naked eyes.
Owner:AUTOBIO DIAGNOSTICS CO LTD

Purposes of PMNs in preparation of medicine for treating and/or preventing autoimmune hepatitis

The invention relates purposes of PMNs in preparation of medicine for treating and / or preventing autoimmune hepatitis, and belongs to the field of medicine. On one hand, the invention provides the purpose of the PMNs in the preparation of the medicine for treating and / or preventing autoimmune hepatitis and the purpose in preparation of medicine for clearing apoptotic hepatocytes. On the other hand, the invention also provides an auxiliary diagnostic kit for the autoimmune hepatitis. The application of the invention can provide a novel option for the clinic diagnosis and treatment of the autoimmune hepatitis; the pain caused by the autoimmune hepatitis on a patient is favorably relieved; and important social benefits and economic benefits are realized.
Owner:SICHUAN UNIV
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