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Chinese medicine composition for treating autoimmune liver disease, and preparation method thereof

An autoimmune and compositional technology, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., can solve the problems of no obvious benefit in long-term survival rate of patients, poor patient compliance, and obvious side effects

Inactive Publication Date: 2013-09-11
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term studies have shown that these drugs have no significant benefit on the long-term survival rate of patients, cannot reduce the incidence of end-point events, and have obvious side effects and poor patient compliance

Method used

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  • Chinese medicine composition for treating autoimmune liver disease, and preparation method thereof
  • Chinese medicine composition for treating autoimmune liver disease, and preparation method thereof
  • Chinese medicine composition for treating autoimmune liver disease, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Party:

[0042] 1000 parts cooked rhubarb 1000 parts madder

[0043] 1000 parts of Forsythia 1000 parts

[0044] Gentiana 1000 parts licorice 1000 parts

[0045] Preparation:

[0046] (1) taking various raw materials according to the weight parts;

[0047] (2) Add 10 times the amount of water to the cooked rhubarb, madder, forsythia, scutellaria, Gentiana and licorice weighed in step (1), decoct twice for 1.5 hours each time, combine the decoctions, and filter , the filtrate is concentrated into a liquid medicine with a relative density of 1.10-1.20 (60°C);

[0048] (3) Add ethanol to the medicinal solution prepared in step (2) so that its alcohol content is 70%, stir fully, let it stand overnight, filter off the precipitate, and reclaim ethanol from the filtrate and concentrate to a relative density of 1.10 ~1.25(60℃) clear ointment, dried into dry powder;

[0049] (4) After adding the dry powder obtained in the step (3) into microcrystalline cellulose, granulati...

Embodiment 2

[0051] Party:

[0052] 1200 parts of cooked rhubarb and 1500 parts of madder

[0053] 1500 parts of Forsythia 1200 parts

[0054] Gentiana 1200 parts licorice 1000 parts

[0055] Preparation method: the preparation method is the same as in Example 1.

Embodiment 3

[0057] Party:

[0058] 1500 parts of cooked rhubarb and 1200 parts of madder

[0059] 1500 parts of Forsythia 1500 parts

[0060] Gentiana 1200 parts Licorice 1000 parts

[0061] Preparation method: the preparation method is the same as in Example 1.

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Abstract

The invention discloses a Chinese medicine composition for treating an autoimmune liver disease. The Chinese medicine composition is prepared from the Chinese medicinal materials, namely rheum officinale, radix rubiae, fructus forsythia, herba siegesbeckiae, large-leaved gentian and liquorice. The invention also discloses a preparation method of the Chinese medicine composition and application of the Chinese medicine composition. The composition has the effects of clearing away heat and toxic materials, smoothing liver-gallbladder, and promoting blood circulation to remove blood stasis, and is mainly used for treating autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, and more specifically relates to a traditional Chinese medicine composition for treating autoimmune liver disease and a preparation method thereof. Background technique [0002] Autoimmune liver diseases (AILD) are a group of autoimmune-mediated hepatobiliary system damage diseases, mainly including autoimmune hepatitis (AIH), primary biliary cirrhosis, PBC), primary sclerosing cholangitis (PSC), and overlap syndromes of any two of these three diseases. [0003] Epidemiological surveys show that AILD patients are on the rise in China, and more and more people are threatened by AILD. This group of diseases recurs and persists, and is an important cause of liver failure. At present, its intervention measures are mainly symptomatic and supportive treatment, and there is no radical cure. Various reports have shown that traditional Chinese medicine intervenes in autoimmune liver disease...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P1/16
Inventor 罗生强孙永强刘红虹浦仕彪张萍王伽伯肖小河
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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