108results about How to "Enhance secretory function" patented technology

The invention relates to a single chimeric converter for a T-cell signal and application thereof, which belongs to the fields of molecular biology and immunology. Specifically speaking, the single chimeric converter is formed by connection of a polypeptide highly efficiently bonding with immunosuppression molecules on the surfaces of tumor cells and/or tumor matrix cells to a transmembrane domain originated from a high-affinity receptor and an intracellular peptide fragment of a costimulatory signal molecule through a hinge structure. Out-membrane polypeptide receives a signal of the immunosuppression molecules on the surfaces of tumor cells and/or tumor matrix cells and transmits the signal into a cell, a second signal of immune cells is activated through the intracellular peptide fragment of the costimulatory signal molecule, so multiplication capacity of the immune cells and the secretion function of cell factors are enhanced, and the survival time of the activated immune cells is prolonged; thus, side-effects of a tumor immunosuppression microenvironment on adoptive cell therapy effector cells are overcome.

The invention provides an externally-used pharmaceutical composition for vaginal sanitation and treating gynaecologic diseases and its preparing process, wherein the medicament is prepared from bee glue extract, oil of aromatic turmeric, alkanna tinctoria extract and purple perilla seed as raw material through steps of supercritical CO2 separation and abstraction, molecular distillation, low-temperature sterilization and centrifugation, sound film separation. The medicament can be made into bottle-packed preparations or soft capsules.

The invention discloses special dietary seafood for postabortal and postpartum women. The special dietary seafood is prepared by mixing food-borne marine oligopeptide serving as a main raw material, active polysaccharide of a marine organism, dried marine algae powder, nutrient amino acid, oligosaccharide, nutrients, vitamins and mineral substances. The special dietary seafood can be prepared into powdery or granular food which is taken by dissolving in warm boiled water. The special dietary seafood is easy to dissolve, has the maximum biological absorbance and the maximum bioavailability to a human body, provides marine high-grade protein, active factors and nutrient components for the body, supplements various vitamins and mineral substances which are necessary to the human body, contributes to improving the nutritional status of the postabortal and postpartum women, can quickly restore the physique and improve the immunity of the body through the combined action of various factors such as the food-borne marine oligopeptide, bioactive ingredients in the active polysaccharide of the marine organism, the dried marine algae powder, the nutrient amino acid and the like, prevents changes in figure after abortion, keeps smooth skin, and is suitable for the postabortal and postpartum women.

Gel for preventing and treating gynecological inflammation is disclosed. Raw materials for preparation active components of the gel are composed of hydroxyethyl cellulose, phellodendron, common cnidium fruit, stemona, matrine, chlorhexidine acetate, menthol and borneol. By combining Chinese herbal medicines and chemical medicines for synergism, the gel has effects of rapidly inhibiting and killing pathogenic microorganisms such as staphylococcus aureus, mold, pseudomonas aeruginosa and the like, and has remarkable curative effects on chronic gynecological inflammations such as cervical erosion, leukorrhea with reddish discharge, trichomonas vaginitis and vaginal fungal infection, etc.

The invention belongs to the fields of molecular biology and immunology, and relates to chimeric chemokines receptors capable of making T cells tend to tumor locations. Specifically, the chimeric chemokines receptors are formed in a manner that a peptide fragment of a generated factor secreted by efficiently-combined tumor cells or tumor stromal cells is connected with a transmembrane region originated from a high-affinity receptor and a signal domain peptide fragment capable of making the T cells efficiently migrated through hinge structures. A membrane outer peptide fragment receives a corresponding factor signal and transfers the signal into cells, and a related path for promoting T cell chemotaxis is started through an intracellular region of the signal domain peptide fragment capable of promoting the migration of the T cells, so that the T cells modified by the chimeric chemokines receptors have a characteristic of migrating to the corresponding factor high concentration direction, and a normal tumor killing activity is not weaken, so as to ensure the tumor adoptive cell therapy effector T cells can efficiently reach the tumor nidus locations, and play a role in treatment.

The invention relates to a pre-stimulating stem cell as well as a preparation method and application thereof. The preparation method comprises the following steps of selecting non-target stem cells asauxiliary cells; inducing the auxiliary cells for pyroptosis; obtaining pyroptosis cells, secreta of pyroptosis cells and/or extracts of the pyroptosis cells for culturing stem cells. The preparationmethod provided by the invention can be used for obtaining the stem cells prestimulated by the secreta of the pyroptosis cells; the stem cells can adapt to the natural inflammatory environment; the restoration capability of the stem cells on the damage region can be improved; the method belongs to new breakthrough in the seed material pretreatment in the tissue engineering field; meanwhile, a feasible scheme is provided for pre-stimulating stem cells and solving the problem of clinic disease treatment.

The invention discloses composite type freshwater fish phagostimulant which comprises the following raw materials in parts by weight: dimethyl-beta-propiothetin, glycine betaine, earthworm powder, locust powder, amino acid, nucleotide, a sweetening agent, a flavoring agent, an acidulant, a piquancy agent and a flavor enhancer. The phagostimulant is prepared by the following steps: weighting the raw material according to the ratio, putting the raw material into a mixing machine, and stirring for 10-15 minutes at the rotation speed of 200-400 r/minutes so as to uniformly mix the raw materials till the variable coefficient of the obtained mixture is less than or equal to 3%, thereby obtaining the composite type freshwater fish phagostimulant. The composite type freshwater fish phagostimulant integrates the effects of the sweetening agent, the flavoring agent, the acidulant, the piquancy agent and the flavor enhancer, is a natural additive, and can effectively increasing the feeding amount and the growth speed of freshwater fishes, shortening the growth period, improving the immunity of fish bodies and increasing the survival rates; by using the phagostimulant as an additive of freshwater feed, the feeding rate of the freshwater fishes to feed hard to digest is increased, the use range and the use amount of non-ordinary feed raw materials are increased, the feed cost is lowered, and the production benefits are increased.

The invention relates to a separation culture method for chick germinal crescent source PGCs. The method comprises the following steps that firstly, according to a separation method, a clean chick embryo without yolk contamination is extracted from a hatching egg through a filter film pasting method, and then germinal crescent tissue is obtained from the chick embryo; secondly, the germinal crescent tissue is digested into single cells through pancreatin, and purification is carried out on the PGCs in the single cells; thirdly, the purified PGCs are placed in a culture system including a BRL-3A cell feed layer and a PGCs complete culture solution to be cultured. The PGCs come from the chick embryo germinal crescent zone, the PGCs content of the 5-8 HH period chick embryo germinal crescent zone is high, better proliferation vitality is achieved, and high-level pluripotency is maintained. The chick embryo germinal disc is separated through the filter film pasting method, operation is easy, repeatability is good, the clean chick embryo without yolk contamination is separated from the hatching egg, and the purified PGCs are obtained. The PGCs cultured through separation can be proliferated to the maximum for later experiment operation.

The invention relates to a preparation method of the activation immune health-preserving water which is prepared by activating water with medical stone and Tourmaline ore. For the health-preserving water, contaminating and harmful matters in water are absorbed and removed and the water is radiated by far infrared rays and anions so as to effectively enhance the water quality and disintegrate macromolecular beams in water to convert the macromolecular beams into micro-molecular beams which are more activated and beneficial to health. Drinking the health-preserving water can drain the harmful matters in cells of body so as to promote metabolism, adjust the central nervous system and antagonistic system, activate cells, promote metabolism and purify blood, thus achieving the ideal effects of eliminating fatigue, prolonging life and keeping health.

The invention discloses gynecological gel, which is mainly prepared from the following raw materials in part by weight: 3 to 20 parts of gallic acid, 5 to 15 parts of himalayan mayapple, 3 to 8 parts of echinacea purpurea extract, 4 to 11 parts of morinda citrifolia extract, 3 to 9 parts of propolis, 1 to 19 parts of Chinese globeflower flower, 8 to 20 parts of rhodiola, 7 to 17 parts of lightyellow sophora root, 3 to 12 parts of realgar, 3 to 8 parts of coptis, 4 to 13 parts of saffron, 2 to 6 parts of vitamin E and 2 to 8 parts of borneol. While curing diseases, the gynecological gel avoids destroying environment of the genital tract, killing beneficial bacteria, arousing medicine resistance and tolerance and wounding human bodies. The gynecological gel disclosed by the invention is more suitable and safer to use, can reduce damage caused by the toxic and side effect of medicines to human bodies, and can improve the immunity of human bodies to protect patients against the toxic and side effect of the medicines.

The invention provides a skin-care composition containing lotus active ingredients and a preparation method of the skin-care composition. The skin-care composition comprises the following components: glycerin, 1,3-butanediol, squalene, polydimethylsiloxane, modified polydimethylsiloxane, dicaprylyl carbonate, isopropyl myristate, cetearyl alcohol, white beeswax, titanium dioxide, iron oxides, sodium chloride, nuciferine, lotus pollen, allantoin, sodium hyaluronate, methylparaben, propylparaben, diazolidinyl urea, iron oxide red, iron oxide yellow, essence and deionized water. The skin-care composition is a powder product which takes full advantage of the lotus active ingredients, and the types and consumption of the various components are set reasonably; by adoption of the reasonable preparation method, the color of the prepared skin-care product approximates the human skin color, and the color difference is avoided after the skin-care product is applied to the skin surface; and meanwhile, the skin moisturizing degree is improved obviously, the skin trans-epidermal water loss is reduced, and the skin elasticity is improved.

The present invention discloses a compound gel preparation-compound tretinoin gel preparation for curing acnes. It is made up by using carbomer, glycerine, propylene alcohol, Tween, triethanolamine, clindamycin phosphate, tretinoin, EDTA and distilled water as raw material through a certain preparation process. Said invention also provides the concrete steps of its preparation method.

The invention discloses a composition for enhancing the breasts and beautifying the face. The composition comprises the following raw material components in parts by weight: 70-90 parts of Chinese yam, 20-30 parts of Chinese angelica, 10-20 parts of ginseng, 15-35 parts of dried longan, 5-10 parts of Chinese wolfberry, 10-25 parts of Chinese dates, 10-15 parts of style and stigma of saffron crocus, 5-15 parts of szechuan lovage rhizome, 10-15 parts of prepared rhizome of adhesive rehmannia, 5-10 parts of Indian buead, 20-25 parts of roasted largehead atractylodes rhizome, 15-25 parts of dried tangerine peel, 20-30 parts of pinellia tuber and 15-25 parts of honey-fried liquorice root.

The invention relates the method for producing renovation pigling Langer-hans' insula cell. The method comprises the following steps: 1 choosing donator: choosing health pigling, at sterility opening abdomen, getting pancreatic, removing integument, vessel, connective tissue in Hank`s liquid at 4Deg.C; 2 separating and purifying Langer-hans' insula cell: separating Langer-hans' insula cell from external secretion tissue with finishing machine, centrifuging with Dextran non-sequence density gradient, getting Langer-hans' insula cell; 3 culturing Langer-hans' insula cell: carrying out CO2 culturing with non-serum microballoon carrier, using RPMI-1640 culture liquid, adding fibrin, packaging the Langer-hans' insula cell in the APA biological film to form microsphere, at 37Deg.C, culturing in the CO2 culture box, changing culture liquid every 48 hours, and getting the product.

The invention relates to a breast enlarging tea wherein the ingredients include kudzuvine root 100g, grape seeds 50g, Chinese caterpillar fungus 100g, gorgon euryale seed 150g, astragalus root 60g, licorice root 50g, raspberry 30g, ginkgo leaves 50g and dahurian angelica root 30g.

The invention provides a cartialgenous and angelica wine which achieves the purpose of beautifying by tonifying the kidney and nourishing the blood. In order to achieve the purpose, the technical scheme is adopted in the invention as follows: the active ingredient is prepared from the following raw materials in parts by weight: 10-30 parts of cartialgenous, 10-30 parts of angelica, 10-30 parts ofginseng, 10-30 parts of Arillus Longan, 10-30 parts of wolfberry fruit, 10-30 parts of chrysanthemum and 800-2400 parts of white spirit of 30-50 degrees. A corresponding preparation method is adopted. The cartialgenous and angelica wine has the effects on tonifying the kidney, nourishing the blood, maintaining beauty and keeping young.

The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition and decoction for treating diabetes as well as a preparation method and an application. The traditional Chinese medicine composition provided by the invention comprises the following raw materials in parts by mass: 20-30 parts of radix astragali seu hedysari,20-30 parts of radix codonopsis, 40-60 parts of rhizoma polygonati, 20-30 parts of fructus lycii, 20-30 parts of fructus ligustri lucidi, 30-50 parts of rhizoma polygonati odorati and 20-30 parts ofradix angelicae sinensis. The traditional Chinese medicine composition provided by the invention has the effects of reducing blood sugar and improving diabetes complications.

The present invention relates to the field of disinfection, the invention relates to an integrated technology and method for dynamically disinfecting air in an aggregated place by using a weakly acidic hypochlorous acid disinfectant. The method comprises the following steps: injecting a weakly acidic hypochlorous acid disinfection solution into a disinfection machine to form aerosol for disinfection, wherein the pH value of the weakly acidic hypochlorous acid disinfection solution is 5.0-6.5, and the weakly acidic hypochlorous acid disinfection solution contains hypochlorous acid water with the concentration of 10-500ppm and sodium chloride with the concentration of 10-9000ppm; the disinfector is one or more of a wall-mounted disinfector, a movable disinfector, corridor type disinfection equipment and an intelligent disinfector; wherein the mist outlet amount of the sterilizer is 0.5-3.5 L/h. According to the method, aiming at different space sizes and different application scenes of crowd aggregation places such as schools, factories, office rooms, shopping malls, supermarkets and hospitals, a weakly acidic hypochlorous acid disinfectant air dynamic continuous disinfection technical specification is established, and aerosol generators suitable for different scenes are customized; and environmental disinfection can be carried out in the presence or absence of people.

The invention relates to a pure traditional Chinese medicine preparation for treating glomerular diseases. The pure traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 30 parts of membranous milkvetch root, 12 parts of amur corktree bark, 15 parts of rhubarb, 40 parts of glabrous greenbrier rhizome, 20 parts of radix salviae miltiorrhizae, 15 parts of oriental waterplantain rhizome, 20 parts of epimedium herb, 15 parts of lalang grass rhizome and 30 parts of motherwort herb, and prepared by decoction, filtration, concentration of filtrate and drying. The pure traditional Chinese medicine preparation has significant efficacy for kidney diseases comprising acute and chronic glomerulonephritis, nephrotic syndrome, hypertensive nephropathy, diabetic nephropathy and early renal insufficiency caused by various reasons; furthermore, the raw materials are easily available, the production process is simple, the toxicity and side effects are small, and the administration is convenient, thereby providing the effective pure traditional Chinese medicine preparation for treating the kidney diseases.

A cell secreta production system based on a photosensitive gene comprises a bioreactor, a light source and a control device, wherein the bioreactor is used for accommodating a secretory cell expressing the photosensitive gene, the light source is used for carrying out illumination stimulation to the secretory cell in the bioreactor, and the control device is connected with the light source to control the light source to give out light. The cell secreta production system utilizes illumination stimulation to facilitate depolarization of the secretory cell, further causes internal flow of Ca2+, enhances cell secretion function, increases yields of genetic engineering medicines and a monoclonal antibody, and improves production efficiency. In addition, a cell secreta production method is further provided.

The invention relates to a gynaecological capsule. The gynaecological capsule comprises 5 to 15 parts of saffron extract, 5 to 10 parts of propolis extract, 5 to 10 parts of lithospermum extract, 10 to 20 parts of a cucumber cell stock solution, 5 to 10 parts of chitosan, 3 to 5 parts of vitamin E, 80 to 120 parts of plant germ essential oil, 3 to 5 parts of betaine and 3 to 5 parts of soya bean lecithin. The capsule is prepared from saffron, propolis, lithospermum, cucumber, plant germs and other natural raw materials through superfine grinding, dynamic ultrasonic extraction, supercritical CO2 separation and extraction, macroporous resin column chromatography, separation via an acoustic film separator, etc. The capsule prepared in the invention can repair vagina mucosa, moisten and restore vaginal wall cells and recover elasticity of vagina, has bacteriostatic, bactericidal and antiviral effect and can be used for treating a variety of vaginal, uterine and pelvic inflammatory diseases; and through long-term usage of the capsule, fitness of the uterus and the ovary can be kept, and arrival of climacterium can be delayed.

The invention provides a method for enhancing the secretion function of mesenchymal stem cells and application, and belongs to the technical field of biology. Research shows that by using Hyaluronic acid sodium (HA) to pretreat umbilical cord mesenchymal stem cells in vitro, the secretion function of the umbilical cord mesenchymal stem cells can be significantly promoted, secretion of HGF, SCF, EGF, VEGF and other factors is promoted, activation of a PI 3K-AKT signal channel is further promoted, and the repair effect on damage is enhanced. The method is simple, convenient, low in cost and highin safety, and therefore the method HAs good practical application value.

The invention belongs to the technical field of medicine and biology, and discloses application of lysophosphatidic acid. Lysophosphatidic acid can be used for regulating expression of inflammatory factors such as IL-1 and/or IL-6, and inflammatory responses are alleviated; meanwhile, collagen secretion by fibroblasts and epidermis proliferation and regeneration can be promoted. Therefore, the lysophosphatidic acid can repair wounds and promote wound healing and has a good application prospect.