The invention belongs to the technical field of medicine, and discloses a medicine for curing a chronic primary glomerular disease and a preparation method thereof. The medicine for curing the chronicprimary glomerular disease is prepared from the materials by weight: 30g of radix astragali seu hedysari, 10g of radix stephaniae tetrandrae, 12g of stir-fried with branrhizoma atractylodis macrocephalae, 15g of herba violae, 10g of bombyx batryticatus, 10g of plantaginis seed, 10g of poria cocos, 12g of fructus rubi and 6g of honey-fried radix glycyrrhizae. The medicine is subjected to rough extraction and is processed into a granule formulation shape. According to the medicine for curing the chronic primary glomerular disease and the preparation method thereof, the formulation is pure traditional Chinese medicine, and the medicine is safe and has no side-effect; the medicine has the efficacy of strengthening a spleen,tonifying a kidney, invigorating qi, consolidating superficies, dispelling pathogenicwind and eliminating dampness, mainly cures the chronic primary glomerular disease, and particularly cures a patient with symptoms of qi deficiency and edema; a chronic kidney disease patient is suitable to take the medicine for a long-term; the clinical oral doses are few, the curative effect is significant, the medicine can effectively facilitate regression of the edema, improve the clinical symptoms, and postpone the disease progression of the chronic primary glomerular disease; and a ranged of applying public is wide, and the medicine can produce social effects well and bring economic effects for the society.