Pharmaceutical composition for treating sicca syndrome, and preparation method and use thereof

A technology of Sjogren's syndrome and composition, which is applied in the field of pharmaceutical composition for the treatment of Sjögren's syndrome, can solve problems such as unsatisfactory effects, and achieve remarkable effects and clear targets

Active Publication Date: 2018-02-09
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These prescriptions can alleviate the pain of patients to a certain extent and adjust the state of the body, but the effect is still not ideal.

Method used

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  • Pharmaceutical composition for treating sicca syndrome, and preparation method and use thereof
  • Pharmaceutical composition for treating sicca syndrome, and preparation method and use thereof

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preparation example Construction

[0036] According to a preferred embodiment of the present invention, the preparation method of the traditional Chinese medicine composition includes the following steps: extracting the Scrophulariaceae, Ophiopogon japonicus, Radix Rehmanniae, Pueraria lobata root, Atractylodes Rhizome and Paeonum radiata with water as a solvent to obtain a water extract. The extraction method is selected from a decoction method, a heating reflux extraction method or an ultrasonic extraction method, more preferably a heating reflux method.

[0037] According to a preferred embodiment of the present invention, the preparation method of the traditional Chinese medicine composition includes the following steps: decoct the Scrophulariae, Ophiopogon japonicus, Shengdi, Pueraria lobata root, Atractylodes Rhizome, and Dan Bark in water, each time adding water for each raw material The total weight of the medicine is 2 to 6 times, the number of decoctions is 1 to 3 times, and the decoction time is 10 to 30...

Embodiment approach

[0039] According to another preferred embodiment of the present invention, the preparation method of the traditional Chinese medicine composition includes the following steps:

[0040] 1) Pueraria lobata and Atractylodes macrocephala are extracted with 50-75 vol% ethanol aqueous solution as a solvent, and the dregs are used as a solvent, and the extract is concentrated and dried to obtain an ethanol extract;

[0041] 2) Combine Scrophulariaceae, Ophiopogon japonicus, raw rehmanniae and dan bark with the medicinal residue obtained in step 1), add water to extract, concentrate the extract, and dry to obtain a water extract;

[0042] 3) The ethanol extract and the water extract are uniformly mixed and crushed to obtain the traditional Chinese medicine composition.

[0043] The traditional Chinese medicine composition prepared by the method can significantly reduce the dosage on the premise of keeping the medicinal effect basically unchanged.

[0044] In the present invention, in step (1), ...

Embodiment 1

[0050] Take 30 parts by weight of Scrophulariaceae, 24 parts by weight of Ophiopogon japonicus, 24 parts by weight of raw land, 30 parts by weight of Pueraria lobata root, 20 parts by weight of Atractylodes macrocephala and 15 parts by weight of Danpi and decocted with water. The amount of water added each time is 3 of the total weight of each raw material. The number of decocting is 2 times, the first decocting time is 20 minutes, and the second decocting time is 10 minutes, the medicine residue is removed to obtain the extract. The extract is concentrated and dried to obtain a traditional Chinese medicine composition.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating sicca syndrome, and a preparation method and use thereof. The traditional Chinese medicine composition is prepared from22-35 parts by weight of radix scrophulariae, 20-30 parts by weight of radix ophiopogonis, 18-26 parts by weight of radix rehmanniae, 25-38 parts by weight of radix puerariae, 15-25 parts by weight ofrhizoma atractylodis and 12-18 parts by weight of root bark of the peony tree. The traditional Chinese medicine composition is remarkable in sicca syndrome treatment effect.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating Sjogren's syndrome, as well as its preparation method and application. Background technique [0002] Sjogren’s syndrome, also known as Sjogren’s syndrome, is a chronic inflammatory autoimmune disease that mainly affects the exocrine glands. Lymphocyte-mediated lesions mainly invade the lacrimal glands and large and small salivary glands, leading to gland destruction and Decreased secretion, its clinical manifestations are mainly gland changes, such as dry mouth, keratoconjunctivitis sicca, parotid gland swelling, and other parts of the glands such as skin, vagina, nose, trachea, and digestive tract. . It ranks first in diffuse connective tissue disease and has a tendency of increasing. The incidence of Sjogren’s syndrome in women is significantly higher than that in men, and the ratio of men to women is about 1:9. At present, the cause of Sjogren’s syndrome is unknown, and modern medical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P37/00
CPCA61K36/284A61K36/488A61K36/65A61K36/71A61K36/804A61K36/808A61K36/8968A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 吴晓丹杨勇张加余张林
Owner BEIJING UNIV OF CHINESE MEDICINE
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