2 results about "Joint destruction" patented technology

The invention provides a traditional Chinese medicine composition for treating early rheumatoid arthritis and a preparation method thereof, and the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 8-12 parts of radix bupleuri, 8-12 parts of cassia twig, 8-12 parts of radix stephaniae tetrandrae, 15-25 parts of radix clematidis, 10-20 parts of rhizoma corydalis, 5-15 parts of radix scutellariae, 8-16 parts of radix angelicae, 15-25 parts of radix paeoniae alba and 3-8 parts of liquorice. The traditional Chinese medicine composition has the beneficial effects that the traditional Chinese medicine composition for treating early rheumatoid arthritis is a pure traditional Chinese medicine prescription, is good in clinical curative effect, can promote recovery of joint meridians and collaterals, is small in toxic and side effects, is wide in medicine source, is low in cost, and is suitable for popularization and application. The traditional Chinese medicine composition is of great significance in further improving the clinical curative effect of traditional Chinese medicine on early rheumatoid arthritis and preventing joint damage, deformity or dysfunction, and is suitable for clinical popularization and application.

The application discloses application of isoprenyl cysteine carboxymethyltransferase as a rheumatoid arthritis treatment target in preparation of a rheumatoid arthritis treatment drug. The application finds that the expression of ICMT is down-regulated after NSUN2 is knocked out, further research on the expression level of ICMT in RA FLS finds that the mRNA and protein expression of RA FLS ICMT is obviously up-regulated, the cell migration and invasion ability is reduced after ICMT is knocked down, and the expression of MMPs such as MMP1, MMP3 and MMP9 of RA FLS is obviously inhibited. The above results show that ICMT can regulate the abnormal migration and invasion of RA FLS, and targeting ICMT can become a new means to prevent RA joint destruction. Therefore, the application provides an effective treatment target for RA, and provides a new idea for clinical treatment of RA.