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Detumescence pain-relieving Babu plaster and preparing method

A technology for reducing swelling and relieving pain, and cataplasm ointment, which is applied in the direction of non-central analgesics, anti-inflammatory agents, and antiviral agents. It can solve the problems of volatile cork solvents, large skin irritation, and turbidity, and achieve a reinforced system Stability, maintenance of matrix stability, effect of increasing space

Active Publication Date: 2008-01-09
广西壮族自治区花红药业集团股份公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although there are many traditional Chinese medicine preparations for the treatment of bruises and rheumatic bone pain clinically, most of them have certain defects. For example, the glass container of the tincture is fragile when transported and carried. or precipitation; the adhesive plaster layer is relatively thin, the drug load is small, the duration of the drug effect is short, and it is highly irritating to the skin, etc., such as the swelling and pain-relieving tincture disclosed by the applicant

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] API:

[0061] Woody fragrance 78.3 grams Fangfeng 78.3 grams Nepeta 78.3 grams

[0062] Asarum 78.3g, Wujiapi 78.3g, Guizhi 78.3g

[0063] Achyranthes bidentata 78.3 grams Chuanxiong 78.3 grams Xu Changqing 78.3 grams

[0064] Angelica dahurica 116.7 grams Curcuma 78.3 grams Red Eucommia 116.7 grams

[0065] Big Luo Umbrella 166.7g Xiao Luo Umbrella 116.7g Double-faced Needle 166.7g

[0066] Huangteng 158.3 grams Gardenia 166.7 grams Triangular 116.7 grams

[0067] Agarwood 54.2g Camphor 91.7g Menthol 91.7g

[0068] Composition of matrix excipients:

[0069] Carbomer: 250g Povidone K30: 250g Povidone K90: 750g

[0070] Gelatin: 1000g Gum Arabic: 500g Glycerin: 1500g

[0071] Lauroazepam: 200g Macrogol 400: 250g Polysorbate-80: 80g

[0072] Sodium hydroxide: 100 grams

[0073] (1), the raw materials Fangfeng, Nepeta, Asarum, Achyranthes bidentata, Chuanxiong, Xu Changqing, Curcuma, Daluosan, Xiaoluosan, Liangmianzhen, Sanleng, Guizhi, Angelica, Red Eucommia, Woo...

Embodiment 2

[0079] API:

[0080] Woody fragrance 78.3 grams Fangfeng 78.3 grams Nepeta 78.3 grams

[0081] Asarum 78.3g, Wujiapi 78.3g, Guizhi 78.3g

[0082] Achyranthes bidentata 78.3 grams Chuanxiong 78.3 grams Xu Changqing 78.3 grams

[0083] Angelica dahurica 116.7 grams Curcuma 78.3 grams Red Eucommia 116.7 grams

[0084] Big Luo Umbrella 166.7g Xiao Luo Umbrella 116.7g Double-faced Needle 166.7g

[0085] Huangteng 158.3 grams Gardenia 166.7 grams Triangular 116.7 grams

[0086] Agarwood 54.2g Camphor 91.7g Menthol 91.7g

[0087] Composition of matrix excipients:

[0088] Carbomer: 300g Povidone K30: 200g Povidone K90: 1100g

[0089] Gelatin: 1400g Gum Arabic: 1000g Glycerin: 1600g

[0090] Lauroazepam: 300g Macrogol 400: 400g Polysorbate-80: 100g

[0091] Sodium hydroxide: 150 grams

[0092] (1), the raw materials Fangfeng, Nepeta, Asarum, Achyranthes bidentata, Chuanxiong, Xu Changqing, Curcuma, Daluosan, Xiaoluosan, Liangmianzhen, Sanleng, Guizhi, Angelica, Red Eucommia, ...

Embodiment 3

[0098] API:

[0099] Woody fragrance 78.3 grams Fangfeng 78.3 grams Nepeta 78.3 grams

[0100] Asarum 78.3g, Wujiapi 78.3g, Guizhi 78.3g

[0101] Achyranthes bidentata 78.3 grams Chuanxiong 78.3 grams Xu Changqing 78.3 grams

[0102] Angelica dahurica 156.6 grams Curcuma 78.3 grams Red Eucommia 156.6 grams

[0103] Big Luo Umbrella 234.9g Xiao Luo Umbrella 156.6g Double-faced Needle 234.9g

[0104]Huangteng 195.75g Gardenia 234.9g Triangular 156.6g

[0105] Agarwood 39.15g Camphor 125.28g Menthol 125.28g

[0106] Composition of matrix excipients:

[0107] Carbomer: 200g Povidone K30: 200g Povidone K90: 1000g

[0108] Gelatin: 1200g Gum Arabic: 800g Glycerin: 1600g

[0109] Lauroazepam: 200g Macrogol 400: 200g Polysorbate-80: 80g

[0110] Sodium hydroxide: 100 grams

[0111] (1), add 5 times the amount of water to the raw materials Fangfeng, Schizonepeta, Asarum, Chuanxiong, Curcuma, Sanleng, Woody, and Agarwood, steam distillation, and collect volatile oil. Grind Ach...

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PUM

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Abstract

The invention is concerned with a kind of cataplasma for reducing swelling and ease pain and its preparation method, relating to active constitutent and matrix. The active constitutent is made of ledebouriella root, herba schizonepetae, asarum herb, Achyranthes bidentata Bl, chuanxiong rhizome, panicled swallowwort root, Rhizoma Curcumae, Ardisia crenata L, Fordia Cauliflora Hemsl, prickly ash, burreed tuber, cassia twig, dahurian angelica root, ichnocarpus loiganthus, auckandia root, fibraurea stem, acanthopanax bark, cape jasmine, eagle ood, bornanone and mentha camphor. The matrix relates to bond, emulsifier, humectant, penetration enhancer and pH moderator. This invention also relates to the component of matrix and the preparation method of cataplasma. It uses to cure wind dampness and bone ache, traumatic injury, inflammatory process of tissue of unknown origin and parotitis ache with definite effect in rapid and without side effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition for reducing swelling and relieving pain, in particular to a traditional Chinese medicine Pabu ointment used for treating rheumatic bone pain, bruises, nameless swelling and pain, and mumps swelling and pain. Background technique [0002] Rheumatism is a universally recognized difficult disease. According to the statistics of the World Health Organization, there are nearly 40 million patients who are disabled due to rheumatism every year. In China alone, there are as many as 20 million patients with rheumatism and rheumatoid. One of them is a critically ill patient. Among the nearly 100 million elderly people, there are at least 50 million patients with bone and joint diseases. Rheumatism causes inconvenient movement in daily life and work to patients, and has a high disability rate, which has a great impact on the physiology and psychology of the patients themselves, and forms a great burden on th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/70A61P29/00A61P19/00A61P31/12A61K31/125
Inventor 马莉韦飞燕韩峰高静
Owner 广西壮族自治区花红药业集团股份公司
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