Medicinal composition for treating glioma, preparation method and preparation thereof

A brain glioma and composition technology, applied in the field of medicine, can solve the problems of large toxic and side effects, delay, and large side effects, and achieve the effects of stable drug content, convenient quality control, and reduced side effects

Inactive Publication Date: 2008-02-13
TASLY HLDG GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few drugs used for chemotherapy of glioma, and the existing chemotherapy drugs are nitrosoureas such as nitrosourea alkylating agents carmustine (BCNU) and nitrosourea (CCNU), or PVC scheme ( procarbazine + vincristine + CCNU), but its disadvantage is that the plasma half-life is very short; the side effects are large, and it has the effects of ...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] The preparation of embodiment 1 borneol (or menthol) solid dispersion

[0078] Weigh 100.0g of borneol (or menthol), 100.0g of PEG4000, and 200g of PVPk30, dissolve them together in ethanol, and evaporate the ethanol at 80°C to obtain the product.

Embodiment 2

[0079] The preparation of embodiment 2 borneol (or menthol) solid dispersion

[0080] Weigh 50.0g of borneol (or menthol) and 120.0g of PVPk30, dissolve them together in ethyl acetate, and evaporate the ethyl acetate at 40°C to obtain it.

Embodiment 3

[0081] The preparation of embodiment 3 borneol (or menthol) cyclodextrin inclusion compound

[0082]Weigh 10.0g of borneol (or menthol) and dissolve it in an appropriate amount of acetone; weigh 60.0g of α-cyclodextrin to prepare a saturated aqueous solution of α-cyclodextrin; Slowly add the acetone solution of borneol (or menthol) dropwise to the saturated aqueous solution of α-cyclodextrin, stir for 80 minutes, refrigerate, dry in vacuum at low temperature until solid, grind, wash with ethyl acetate and dry in the air , to obtain white loose clathrate powder.

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Abstract

The present invention provides a medicine compound for glioma treatment, which comprises Temozolomide, the second part comprising the Borneo camphor with or without the Menthol. The weight ratio of the Temozolomide to the Borneo camphor or the Menthol is 1 till 50 to 2 till 100. The present invention also provides a preparation method for the agent or the compound agent. The medicine compound prescription provided in the present invention has properties of low taking dose, good therapy effect and little side effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular, the invention relates to a composition for treating glioma and a preparation method thereof. Background technique [0002] Brain tumor disease refers to tumors that occur in the brain, and can be divided into primary brain tumors and metastatic tumors transferred from lung tumors according to the source of the lesion. The biggest difference between brain tumors and tumors in other parts is that brain tumors are surrounded by skulls. It is for this reason that doctors warn us that we should not take it lightly when we suffer from brain tumors. Even benign brain tumors may threaten our health. life. The brain is the "headquarters" of the human body. If a tumor occurs in the brain, it will oppress the brain, damage the function of the brain, and cause disease in the whole body; because the brain is also the center of thinking, personality and emotion, brain tumors bring not only Du...

Claims

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Application Information

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IPC IPC(8): A61K31/4188A61K9/00A61P35/00A61K31/045
Inventor 陈建明叶正良张广明彭久合
Owner TASLY HLDG GRP CO LTD
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