121 results about "Gastric ulcerations" patented technology

The invention relates to the field of medicine synthesis, and discloses a GLP-1 / GIP / GCG tri-agonist compound. The GLP-1 / GIP / GCG three-agonist compound is used for preparing a medicine composition for treating diseases, and the application of the medicine composition in preparing a medicine for treating at least one of the following diseases, namely, the GLP-1 / GIP / GCG three-agonist compound, and the GLP-1 / GIP / GCG three-agonist compound. The diseases include type II diabetes mellitus, impaired glucose tolerance, type I diabetes mellitus, obesity, hypertension, metabolic syndrome, dyslipidemia, cognitive impairment, atherosclerosis, myocardial infarction, coronary heart disease, cardiovascular disease, stroke, inflammatory bowel syndrome and / or dyspepsia or gastric ulcer, hepatic fibrosis disease and pulmonary fibrosis disease.

The invention relates to the field of medicine synthesis, and discloses a GLP-1 / GIP / GCG tri-agonist compound. The GLP-1 / GIP / GCG three-agonist compound is used for preparing a medicine composition for treating diseases, and the application of the medicine composition in preparing a medicine for treating at least one of the following diseases, namely, the GLP-1 / GIP / GCG three-agonist compound, and the GLP-1 / GIP / GCG three-agonist compound. The diseases include type II diabetes mellitus, impaired glucose tolerance, type I diabetes mellitus, obesity, hypertension, metabolic syndrome, dyslipidemia, cognitive impairment, atherosclerosis, myocardial infarction, coronary heart disease, cardiovascular disease, stroke, inflammatory bowel syndrome and / or dyspepsia or gastric ulcer, hepatic fibrosis disease and pulmonary fibrosis disease.

The invention provides application of bifidobacterium breve in preparation of a product for resisting gastric ulcer and gastric inflammation caused by helicobacter pylori, and belongs to the technical field of microorganisms. The preservation number of the bifidobacterium breve NKU BB1-2 is GDMCC NO: 65956, and the bifidobacterium breve NKU BB1-2 can antagonize helicobacter pylori colonization and relieve gastric ulcer aggravation caused by helicobacter pylori. The bifidobacterium breve NKU BB 1-2 has good helicobacter pylori antagonism ability in an in-vitro environment, and can significantly inhibit colonization growth of helicobacter pylori; animal experiments show that the bifidobacterium breve NKU BB 1-2 can relieve gastric ulcer aggravation caused by helicobacter pylori infection in vivo, and the gastric mucosa lesion is relieved, the stomach inflammation is relieved, and the stomach pH value is increased; in addition, the bifidobacterium breve NKU BB1-2 can also significantly improve the diversity of stomach microorganisms, regulate and improve the structure of the stomach microorganisms, and assist antagonism and removal of helicobacter pylori infection.

The invention belongs to the technical field of biology, and particularly relates to lactobacillus paracasei and application thereof in improvement of gastric ulcer. The lactobacillus paracasei NCU-21 is preserved in China General Microbiological Culture Collection Center (CGMCC) on September 25, 2023, the address of the lactobacillus paracasei NCU-21 is No.3, No.1 yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number of the lactobacillus paracasei NCU-21 is CGMCC NO.28538. The lactobacillus paracasei NCU-21 is named as Lactobacillus paracasei NCU-21. The invention provides a strain of lactobacillus paracasei NCU-21, and the data result of the embodiment shows that the lactobacillus paracasei NCU-21 can promote the healing of ethanol gastric ulcer and improve gastric mucosal lesion caused by oxidative stress. In addition, the strain can also regulate stomach microbiota, improve ethanol-induced gastric mucosal lesion, improve ethanol-induced intestinal inflammation, repair intestinal barriers and relieve ethanol-induced intestinal microbiota disorder.

The invention belongs to the technical field of biological medicines, and relates to application of mannatide in preparation of a medicine for treating alcoholic gastric ulcer. The mannatide disclosed by the invention can be used for remarkably relieving gastric tissue hemorrhagic lesion and ulcer conditions of alcoholic gastric ulcer for the first time, and the mechanism comprises the following steps: reducing active oxygen generated by alcohol toxicity, and improving oxidative stress of a body by improving antioxidant enzyme activity of the gastric tissue; the inflammatory response of the organism is regulated by regulating and controlling an Akt / NF-kB pathway; a Bax-related apoptosis pathway is inhibited to protect gastric mucosa cells from alcohol-induced apoptosis, so that the integrity of gastric tissue mucosa is protected; the intestinal flora disorder caused by alcohol intake is regulated and controlled, and the acute alcoholic gastric ulcer is prevented by improving the intestinal flora composition of the alcoholic gastric ulcer. The application range of the mannatide is widened, and more solutions are provided for prevention or treatment of acute alcoholic gastric ulcer.

The invention provides application of pinostrobin in preparation of a medicine for treating gastric ulcer, and belongs to the technical field of biological medicine. The pinostrobin provided by the invention realizes the anti-gastric ulcer effect by improving the gastric mucosa blood flow volume, inhibiting inflammatory reaction, inhibiting oxidation reaction and maintaining the integrity of the gastric mucus barrier. Pinostrobin can reduce the gastric ulcer area of rats and increase the pain threshold value; the content of ET-1 in plasma is reduced, and the repairing effect of gastric mucosa is enhanced; the contents of TNF-alpha and IL-6 are reduced, the content of IL-10 is increased, and the anti-inflammatory effect is enhanced; the content of T-SOD in plasma is increased, the content of MPO is reduced, and the antioxidant effect is enhanced. The pinostrobin is expected to be used as a new medicine for treating gastric ulcer.

The invention relates to the technical field of biology, and discloses a soybean extract as well as an extraction method and application thereof. The extraction method of the soybean extract comprises the following steps: performing circulating freezing and thawing treatment on soybeans to obtain pretreated soybeans; putting the pretreated soybeans into a microwave reaction kettle, and carrying out primary microwave extraction; after the primary microwave extraction is finished, condensing gas in the microwave reaction kettle to obtain a soybean extract A; crushing soybeans, and mixing the crushed soybeans with deionized water to obtain soybean slurry; placing the soybean slurry in a microwave reaction kettle, introducing nitrogen into the microwave reaction kettle, and carrying out secondary microwave extraction; filtering the soybean slurry subjected to the secondary microwave extraction by using a ceramic membrane, and freeze-drying to obtain a soybean extract B; and mixing the soybean extract A and the soybean extract B to obtain the soybean extract. The treatment effective rates of the soybean extract on gastric ulcer and gastritis can reach 90.0% and 80.0% respectively, and the soybean extract has good gastric ulcer and gastritis treatment effects.

The invention belongs to the technical field of medicines, and particularly relates to application of fructus cinnamoii in preparation of a medicine for treating gastric ulcer. The invention discloses the application of the fructus cinnamoii oil in preparation of the gastric ulcer medicine for the first time, specifically, the fructus cinnamoii oil obviously improves the conditions of rat gastric mucosa bleeding, erosion, hyperemia, edema and the like and also obviously reduces the ulcer index of rat gastric tissues, and in addition, the fructus cinnamoii oil can be used for preparing the gastric ulcer medicine by reducing TNF-alpha, IL-6 and MDA. The contents of SOD and GSH are increased to improve the inflammatory reaction and oxidative stress of stomach tissues, so that the effect of protecting the stomach tissues of rats is achieved.

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating or improving prostate diseases and stomach diseases, a traditional Chinese medicine preparation and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials: Chinese lobelia, tripterygium wilfordii, selfheal, dandelion, lophatherum gracile, hydrocotyle verticillata and liquorice. The traditional Chinese medicine composition disclosed by the invention is reasonable in compatibility and synergistic in efficacy, can treat prostate diseases such as chronic prostatitis and benign prostatic hyperplasia and stomach diseases such as chronic gastritis and gastric ulcer at the same time by taking a treatment method of clearing away heat and toxic materials, promoting diuresis and treating stranguria, regulating qi and harmonizing stomach and removing stasis and diminishing swelling, has the advantages of definite curative effect, high safety, low recurrence rate, convenience in taking and the like, and is suitable for clinical popularization.

The present invention discloses a repair functional composition HAmella containing sodium hyaluronate and tremella polysaccharide, belonging to the field of biomedical technology. The preparation method includes: mixing sodium hyaluronate and tremella polysaccharide, dissolving them in water to prepare a polysaccharide aqueous solution; wherein, the molecular weight of the sodium hyaluronate is 100 - 300 KD, and the molecular weight of the tremella polysaccharide is 50 - 200 KD; dissolving saponin in water to prepare an aqueous phase, and then adding camellia oil to the aqueous phase to prepare a camellia oil microemulsion; mixing the polysaccharide aqueous solution and the camellia oil microemulsion evenly, and spray drying to obtain a gastric mucosa protectant. The preparation method of the protectant of the present invention is simple, shows excellent performance in gastrointestinal protection, and has an injury inhibition rate of about 50% in an ethanol-induced gastric ulcer model.

This invention belongs to the field of biomedical technology, specifically relating to a post-biotic hydrogel for relieving alcoholic gastric ulcers, its preparation method, and its application. The post-biotic hydrogel for relieving alcoholic gastric ulcers provided by this invention is mainly prepared from post-biotics of *Lactobacillus rhamnosus* and modified lactoferrin; *Lactobacillus rhamnosus* is *Lactobacillus rhamnosus* JM023. Experiments have confirmed that the post-biotic hydrogel of this invention, when applied to a rat model of alcoholic gastric ulcers, can inhibit the occurrence of gastric ulcers by suppressing oxidative stress and inflammatory responses and increasing the secretion of protective factors. It also alleviates alcoholic gastric ulcers by regulating the expression of metabolic pathways related to oxidation, inflammation, apoptosis, and tissue repair, and by regulating the gastrointestinal flora. In other words, the post-biotic hydrogel of this invention has an effective effect in relieving the symptoms of alcohol-induced gastric ulcers and is suitable for development and application as a drug or health product for relieving alcoholic gastric ulcers.

The present application relates to the technical field of auxiliary identification positioning, in particular to an AI-assisted lesion positioning method and system based on a gastrointestinal endoscope. Based on segmentation boxes of different sizes, a gastric ulcer lesion area and a corresponding confidence level in a gastrointestinal endoscope image are identified. The completeness value of the gastric ulcer lesion area is determined. According to the number of times that a pixel point at each position is divided into the gastric ulcer lesion area under segmentation boxes of different sizes, in combination with the confidence level and the completeness value of the gastric ulcer lesion area to which the pixel point is divided, the region belonging value of each pixel point is obtained. Based on the region belonging value, the pixel points are merged to obtain a preliminary screening lesion area. The region belonging value of the pixel points and the distribution of the region in the preliminary screening lesion area are analyzed to determine the performance bias degree of each preliminary screening lesion area. Based on the performance bias degree, a target gastric ulcer area is determined from the preliminary screening lesion area. The present application improves the identification accuracy of the target gastric ulcer area.

The invention belongs to the field of traditional Chinese medicines, and provides application of a watermelon frost and periplaneta americana composition in preparation of a medicine for treating gastric ulcer caused by helicobacter pylori. The invention provides an application of a mirabilitum praeparatum and periplaneta americana composition in treatment of gastric ulcer, the composition has an effect of inhibiting and killing helicobacter pylori in vitro, and has a good synergistic effect in a specific proportion; the composition can reduce the ulcer index of a gastric ulcer model rat, and has good effects of protecting gastric mucosa and improving gastric ulcer; compared with a control Chinese patent medicine, the medicament prepared from the composition can improve the effective rate of helicobacter pylori induced gastric ulcer and the HP eradication rate. The invention provides a novel pharmaceutical composition for helicobacter pylori induced gastric ulcer, and the pharmaceutical composition is high in safety and few in side effect.

The invention relates to the technical field of preparation of health-care products, in particular to a dendrobium devonianum paxt beverage with a gastric mucosa protection effect as well as a preparation method and application of the dendrobium devonianum paxt beverage. The dendrobium devonianum paxt beverage is prepared from the following components in parts by volume: 80 to 120 parts of dendrobium devonianum paxt primary pulp and 10 to 20 parts of Pu'er tea soup. The dendrobium devonianum paxt. Beverage contains the dendrobium devonianum paxt. Primary pulp and the Pu'er tea soup, the flavone content and the polyphenol content in the beverage obtained by mixing the dendrobium devonianum paxt. Primary pulp and the Pu'er tea soup are high, and the antioxidant and anti-inflammatory effects of the beverage are improved. And a basis is provided for development of health-care products capable of protecting excellent gastric mucosa and treating and preventing gastric ulcer.

The composition is prepared from the following raw materials: 50 to 70 parts of rhizoma dioscoreae, 25 to 35 parts of radix paeoniae alba, 25 to 35 parts of rhizoma atractylodis, 10 to 20 parts of rhizoma zingiberis, 10 to 20 parts of radix cynanchi bungei and 10 to 20 parts of raw fructus crataegi. The preparation method comprises the following steps: 1, raw material pretreatment; 2, superfine grinding; 3, mixing process; and 4, forming process. The traditional Chinese medicine composition has the advantages that the dual effects of diminishing inflammation, sterilizing and repairing tissues are achieved through a specific proportion and a preparation process, the traditional Chinese medicine composition is suitable for treating and preventing chronic gastritis and gastric ulcer diseases, and accurate component protection is achieved through a three-section gradient drying process; differential superfine grinding and plasma activation have a synergistic effect; the double-layer sustained-release pill design realizes accurate matching; and the safety of microorganisms is guaranteed through multi-mode sterilization.

The present invention provides a tegoprazan sugar acid salt and a preparation method therefor, the salt being pharmaceutically usable for gastroesophageal disease, gastroesophageal reflux disease, gastritis, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcer, non-erosive reflux disease (NERD) and the like. The tegoprazan sugar acid salt of the present invention has excellent water solubility and stability of tegoprazan, and thus can be particularly useful as a pharmaceutical injection preparation.

The invention provides application of pinocembrin in preparation of a medicine for treating gastric ulcer, and belongs to the technical field of medicines. The invention aims to provide the application of the pinocembrin as a unique active ingredient in preparation of the medicine for treating gastric ulcer, and the pinocembrin as the medicine for treating gastric ulcer can reduce the ET-1 content in plasma of rats suffering from gastric ulcer caused by absolute ethyl alcohol, increase the NO content and enhance the repairing effect of gastric mucosa; the contents of TNF-alpha and IL-6 are reduced, and the content of IL-10 is increased; the content of T-SOD in plasma is increased, the content of MPO is reduced, and the antioxidant effect is enhanced. Therefore, the pinocembrin has a remarkable treatment effect on the rat gastric ulcer caused by the absolute ethyl alcohol.

The invention is suitable for the technical field of medicine, and provides a stomach medicine capsule and a preparation method thereof, the stomach medicine capsule is prepared from 20-30 parts of Chinese angelica, 7-11 parts of phoenix-tail fern, 15-19 parts of radix berberidis, 5-9 parts of radix aucklandiae, 2-4 parts of reed seed, 13-17 parts of sea snail and auxiliary materials; the preparation method comprises the steps of raw material pretreatment, ethanol reflux extraction, vacuum concentration, spray drying, mixing granulation, capsule filling and packaging. The traditional Chinese medicine raw materials in a specific proportion are screened, the synergistic effect of resisting inflammation and bacteria, regulating qi to relieve pain, nourishing blood and repairing, and relieving acid and protecting the stomach is achieved, and the problems that an existing stomach medicine is single in effect and large in side effect are solved; meanwhile, extraction and drying processes are optimized, the dissolution rate of effective components and the stability of the preparation are improved, and the traditional Chinese medicine composition is suitable for treating stomach diseases such as acute and chronic gastritis, gastric ulcer and hyperacidity, high in safety and suitable for long-term administration.

The invention discloses application of a dibenzo nitrogen heterocyclic compound in preparation of a medicine for treating gastrointestinal diseases, and relates to the technical field of medicinal chemistry. A large amount of screening and verification show that the dibenzo nitrogen heterocyclic compound with the structural general formula can significantly reduce core pathological characteristics of gastric ulcer, such as significant reduction of ulcer lesion, significant reduction of bleeding degree and specific reduction of mucosal edema, and has an ulcer inhibition rate of 36.51%-47.22% for a gastric ulcer animal model. A new thought and a new choice are provided for the development of medicines for treating gastrointestinal diseases.

Helicobacter pylori (HP) is a chronic bacterium that infects the gastric mucosa. It is widespread in the general population, with an infection rate between 55% and 70%. HP is closely related to gastric ulcers and gastritis. Western medicine treatment for HP infection is relatively complex, including bismuth substituents and proton pump inhibitors plus two antibiotics. Gastric ulcers and gastritis are common digestive system diseases. Compound 1, "Exterminate the Ghost," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Scutellaria baicalensis and Fraxinus chinensis, which can eradicate HP. Compound 2, "Ulcer Relief," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Rheum palmatum and Bletilla striata, which can cure gastric ulcers. Compound 3, "Gasitis Relief," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Glycyrrhiza uralensis or Taraxacum mongolicum, made into a tea bag, which can cure chronic gastritis.

The application discloses a stomach-derived limosilactobacillus fermentum LAF-09 and application thereof, and the preservation number of the stomach-derived limosilactobacillus fermentum LAF-09 is GDMCC No. 65656. The inventor of the application screens a stomach-derived limosilactobacillus fermentum LAF-09 from stomach mucosa tissue of healthy people, the strain has strong acid resistance and high proliferation capacity in the stomach, has strong adhesion properties to stomach epithelial GSE-1 cells, can be effectively applied to prevent and treat gastric ulcers caused by indomethacin, and has no obvious side effects.

The invention provides application of Laetanine in preparation of a medicine for preventing and / or treating gastric ulcer, and belongs to the technical field of biological medicine. The medicine prepared from the Laetanine has the effects of relieving gastric ulcer pain, reducing the pH value of gastric juice and reducing the ET-1 content in plasma at the same time. Research confirms that the Lapanine can enable the pH value of gastric juice of a rat to tend to a normal value, increase the contents of PGE2 and T-SOD in plasma and reduce the contents of ET-1, TNF-alpha and IL-6 in the plasma, that is, the Lapanine has the effects of relieving gastric ulcer pain, reducing the pH value of the gastric juice and reducing the content of ET-1 in the plasma at the same time, the specific pharmacological action of the Lapanine in gastric ulcer is further confirmed, and a foundation is laid for clinical use.

The invention relates to the technical field of auxiliary identification and positioning, in particular to an AI auxiliary focus positioning method and system based on a gastrointestinal endoscope. Based on the segmentation frames of different sizes, identifying gastric ulcer focus areas in the gastrointestinal endoscope image and corresponding confidence coefficients; determining the integrity degree value of the gastric ulcer focus area; according to the number of times that the pixel point at each position is divided into the gastric ulcer focus area under the segmentation frames of different sizes, and in combination with the confidence coefficient and the integrity degree value of the gastric ulcer focus area into which the pixel point is divided, obtaining the area affiliation value of each pixel point; based on the value of the region, combining pixel points to obtain a primarily screened focus region; analyzing the area belonging values of the pixel points in the preliminary screening focus areas and the distribution condition of the areas, and determining the expression deviation degree of each preliminary screening focus area; and determining a target gastric ulcer area from the primarily screened focus area based on the expression deviation degree. The recognition accuracy of the target gastric ulcer area is improved.

The embodiment of the invention discloses hydrogel based on self-assembled nanoparticles as well as a preparation method and application of the hydrogel. On the basis of a supramolecular self-assembly technology of the Sanhuang heart-purging decoction, the active components including berberine hydrochloride, baicalin and tannic acid are assembled into nanoparticles and prepared into the hydrogel, the preparation is simple in effective components, the residence time of the effective components in the stomach can be prolonged, the effective components can play a therapeutic effect on the surface of gastric ulcer for a long time, and the curative effect is good. The component homogeneity and the preparation stability are remarkably improved while the synergistic efficacy of the compound is reserved.

The invention discloses a polaprezinc effervescent tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The effervescent tablet is prepared from the following components in parts by weight: 30 to 40 parts of polaprezinc-HP-beta-CD inclusion compound microcapsules, 25 to 40 parts of an effervescing agent, 30 to 45 parts of spray-dried mannitol, 0.8 to 1.5 parts of a sweetening agent and 0.3 to 0.8 part of a lubricating agent, wherein the polaprezinc-HP-beta-CD clathrate compound microcapsule is prepared by the following steps: carrying out clathration on HP-beta-CD and polaprezinc, and then carrying out sugar-coating wrapping on the clathrate and the polaprezinc. The effervescent tablet disclosed by the invention is quick to disintegrate (the time limit is less than or equal to 16s), the dissolution rate in 5min is more than or equal to 97%, the taste is excellent (no metal flavor or gravel feeling), the effervescent tablet is uniformly dispersed and has no precipitate, the content change is less than or equal to 0.16% after the effervescent tablet is accelerated for 6 months, and the stability is excellent; the preparation problem of the insoluble polaprezinc effervescent tablet is effectively solved, the taking compliance of a patient and the bioavailability of the medicine are improved, and the polaprezinc effervescent tablet is suitable for treating gastric ulcer, duodenal ulcer and gastritis.

The application provides a compound extract for treating gastric ulcer, a preparation method and application thereof, and belongs to the technical field of medicines. The compound extract is obtained by using medicinal materials of pachouli and high kankyo through an ethanol degreasing, water extraction and alcohol precipitation process. The application has the advantages of few medicinal materials, simple extraction and preparation process and easy industrialization. Animal efficacy and mechanism researches show that the compound extract can protect the gastric mucosal barrier by synergistically improving the function of the mitochondrial electron transport chain and enhancing the antioxidant stress capacity, and can effectively prevent and treat gastric ulcer.

This invention provides the application of *Bifidobacterium breve* in the preparation of products for treating gastric ulcers and gastric inflammation caused by *Helicobacter pylori*, belonging to the field of microbial technology. The *Bifidobacterium breve* NKU BB1-2 of this invention, with accession number GDMCC NO: 65956, can antagonize *Helicobacter pylori* colonization and alleviate the aggravation of gastric ulcers caused by *Helicobacter pylori*. In vitro, *Bifidobacterium breve* NKU BB1-2 exhibits good antagonistic ability against *Helicobacter pylori*, significantly inhibiting its colonization and growth. Animal experiments show that *Bifidobacterium breve* NKU BB1-2 can alleviate the aggravation of gastric ulcers caused by *Helicobacter pylori* infection in vivo, manifested as reduced gastric mucosal damage, reduced gastric inflammation, and increased gastric pH. Furthermore, *Bifidobacterium breve* NKU BB1-2 can significantly enhance gastric microbial diversity, regulate and improve the gastric microbial structure, and assist in antagonizing and eradicating *Helicobacter pylori* infection.

The invention provides a medicine composition for invigorating stomach and dispelling cold as well as a preparation and application thereof, and the medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of gypsum rubrum, 10-15 parts of fructus amomi rotundus, 10-15 parts of fructus piperis longi powder, 10-15 parts of pomegranate seeds, 10-15 parts of flos carthami, 10-15 parts of radix aucklandiae, 10-15 parts of coriander, 10-15 parts of radix inulae inula and 10-15 parts of pawpaw, the preparation method of the fructus piperis longi powder comprises the following steps: crushing fructus piperis longi, pre-soaking, adding mesoporous silica nanoparticles, adding an ethanol aqueous solution, adjusting the pH value, performing ultrasonic-assisted extraction, filtering, purifying, concentrating and drying to obtain the fructus piperis longi powder; amomum kravanh powder is extracted with the assistance of a deep eutectic solvent, and the content of effective components of the medicine is increased through the preparation method. The pharmaceutical composition disclosed by the invention is scientific in formula and capable of effectively treating sour regurgitation of stomach, gastric ulcer, dyspepsia and inappetence due to the synergistic effect of all the components, and has clinical medication value.

The invention relates to the technical field of biological medicine, and discloses a natural product for targeted inhibition of a KCNQ1 / KCNE2 complex channel and application of the natural product for targeted inhibition of the KCNQ1 / KCNE2 complex channel in preparation of a medicine for treating or preventing gastric ulcer, and an application method of a pharmaceutical composition comprises the following steps: S1, applying the pharmaceutical composition to a medication object; s2, the natural product interacts with a KCNQ1 / KCNE2 complex channel on a gastric wall cell membrane, and potassium ion current of the complex channel is inhibited; s3, weakening functions of H < + > / K < + >-ATPase in gastric wall cells by inhibiting potassium ion current, so that gastric acid secretion is reduced, and gastric ulcer is treated or prevented. According to the invention, gastric acid is indirectly regulated and controlled through targeted inhibition of gastric wall cell KCNQ1 / KCNE2 complex channels, and a new strategy for treating gastric ulcer, which is milder and has safety potential, is provided.