597 results about "Gastric ulcerations" patented technology

The invention provides a health-care flour composition and food and a preparing method thereof. According to the preparing method, hericium erinaceus and flour are used as main raw materials, swelling agents, sweetening agents, oil, salt and the like are added and mixed with water, and then rolling, forming, baking, oil injection and cooling are carried out to obtain various foods made of flour or pastries such as cookies, cakes and noodles. The health-care flour composition and food are even in texture, capable of being stored for a long time easily, good in mouthfeel and rich in nutrient, and market vacancy is filled. The health-care flour composition and food have definite effects in repairing gastric mucosal damage caused by chronic gastritis, or gastric ulcers or duodenal ulcers, relieving abdominal pains caused by chronic gastritis, or gastric ulcers or duodenal ulcers, inhibiting helicobacter pylori, and assisting the treatment of chronic gastritis, gastric ulcers and duodenal ulcers.

The invention discloses a Chinese medicine composition for treating gastric ulcer and a preparation method thereof. The Chinese medicine composition is mainly formed by the following raw medicine materials: Poria cocos, coix seed, prepared frankincense, prepared myrrh, dalbergia wood, storax, rheum officinale, coptis, sangusis draconis, Rhizoma atractylodis, Mangnolia officinalis, fructus amomi, netmeg, Rhizoma atractylodis Macrocephalae, Chinese yam, Herba lycopi, charred catnip, charred Chinese arborvitae twig, dandelion, Mongolian snakegourd root, lightyellow sophora root, honeysuckle, lightyellow sophora root, white paeony root, Taraxacum officinale root, rhizoma cyperi and the like. The Chinese medicine composition of the invention can be prepared into any kind of common oral preparation according to the conventional Chinese medicine preparation method. The invention has the advantages that symptoms such as epigastralgia, ructus, acid regurgitation, heartburn, nausea, vomiting and the like are obviously improved, the clinical curative effect is exact, the curative effect is obvious and the rapid effect is obtained. Moreover, since the Chinese medicine composition is basically combined by homologous plant food medicines regulated in state pharmacopoeia, the cost is low, basically no toxic side effect exists and the like.

The invention discloses a Chinese medicine composite for treating chronic atrophic gastritis and a preparation method thereof. The Chinese medicine composite mainly comprises the following active pharmaceutical ingredients: jobstears seed, rhizoma dioscoreae, pericarpium citri reticulatae, fructus aurantii immaturus, radix aristolochiae, ligusticum chuanxiong, Lignum aquilariae resinatum, rhizoma corydalis, stir-fried frankincense, stir-fried myrrh, pericarpium citri reticulatae viride, radix scrophulariae, rhizoma cyperi, styrax, radix trichosanthis, radix rehmanniae preparata, peach seed, safflower, medicated leaven, fructus setariae germinatus, dandelion, honeysuckle flower, rhizoma coptidis, radix et rhizoma rhei, radish seed, rhizoma curcumae longae, grassleaf sweetflag rhizome, cortex magnoliae officinalis and tuckahoe, and the like. The Chinese medicine composite can be prepared to be any common oral preparation according to the conventional Chinese medicine preparation method. The Chinese medicine composite can obviously improve abdominal distention that is manifest due to more food intake, tastelessness and insipidity, vague pain and complaint in the gastric cavity, lassitude, athrepsy, anorexia, anaemia and the like and the complications including gastric bleeding, gastrelcosis, anaemia and gastric cancer, and the like, which has definite clinical effect, obvious curative effect and fast desired effect.

The invention discloses bletilla polysaccharide, a preparation method and novel application thereof. The bletilla polysaccharide is prepared by the following method: firstly, coarse bletilla powder is taken as a raw material, and is extracted by alcohol; secondly, herb residue is extracted by water; thirdly, resin is used for removing proteins of a concentrated solution; and fourthly, after an eluent is condensed, the bletilla polysaccharide is precipitated by the ethanol. The content of the bletilla polysaccharide prepared by the method is high, reaches 70 to 74 percent, and is improved by 14 to 20 percent compared with the prior technical method, and the bletilla polysaccharide has good protein removal effect. The preparation method can also utilize the herb residue produced in the process of production of bletilla particle medicines as the raw material, so as to save the production cost. The invention also provides the novel application of the bletilla polysaccharide to preparation of medicines for treating gastric ulcer and medicines for treating silicosis and a commonly used medical preparation formulation.

The invention pertains to the technical field of chemical pharmaceutical production and particularly provides a novel preparation method of sofalcone which has a general formula (I) structure and is mainly applied to the treatment of gastric ulcer and chronic gastritis. The preparation method adopts 2-hydroxy-4-(3-methyl-2-butene oxygen) hypnone as a starting material and a target compound sofalcone (I) is finally prepared after reactions with four steps. Compared with synthesis technologies provided by the existing literatures, the method simplifies the processing method of intermediate products, improves the quality and yield of products and reduces costs.

This invention relates to formulations of bisphosphonates such as alendronate. The formulations taught herein enhance bioavailability of bisphosphonates and reduce esophageal and gastric ulcerations associated with them. Also taught herein are methods of preparing the formulations and their clinical use in the treatment of osteoporosis and other bone diseases.

The invention provides a wine decanting and hangover-preventing bevera traditional Chinese medicine extracting solution which is prepared by hawthorn extracting solution, traditional Chinese medicine extracting solution, vitamins and water, wherein the traditional Chinese medicine extracting solution is prepared through extracting semen hoveniae, pueraria lobata ohwi, poria cocos, semen cassiae, chrysanthemi, mint and hericium erinaceus; and the mass ratio of the hawthorn extracting solution to the traditional Chinese medicine extracting solution to the vitamins is (10-30) to (23-80) to (1-2). The hawthorn extracting solution has the effects of improving digestion, promoting qi circulation and removing obstruction in the collateral, gastral cavity bellying and the like; semen hoveniae has the effects of quenching thirst, relieving restlessness, eliminating dampness and heat and relieving alcoholism, and can be used for eliminating alcoholism, vomiting and difficulty in urination and defecation; pueraria lobata ohwi has the effects of powerfully alleviating hangover, clearing heat, relieving internal heat or fever, protecting liver, keeping young and tonifying kidney; poria cocos has the effects of clearing damp and promoting diuresis, tonifying spleen and calming nerves, and eliminating malaise; semen cassiae has the effects of clearing heat and improving eyesight, lubricating intestines and relaxing bowels, alleviating liver heat and headache; chrysanthemi has the effects of clearing away heat and toxic materials, improving eyesight, relieving headache and dizziness; the mint has the effects of dispelling wind-heat and clearing throats; and hericium erinaceus has good effects of helping digestion, benefiting five organs, relieving pain, and alleviate gastric ulcer.

The peptides and precursors thereof, inclusive salts thereof, of the present invention are useful as a pharmaceutical composition, for example as therapeutic or prophylactic agents for hormone-producing tumors, acromegaly, gigantism, dementia, gastric ulcer and the like, hormone secretion inhibitors, tumor growth inhibitors, neural activity or sleep modulators, etc. The DNAs coding for the peptides or precursors of the invention are useful as a pharmaceutical composition, for example as agents for the gene therapy or prevention of hormone-producing tumors, acromegaly, gigantism, dementia, gastric ulcer and the like, hormone secretion inhibitors, tumor growth inhibitors, neural activity or sleep modulators, etc. Furthermore, the DNAs coding for the peptides or precursors of the invention are useful as agents for the gene diagnosis of various diseases, for example, hormone-producing tumors, acromegaly, gigantism, dementia, gastric ulcer, etc. The antibodies against the peptides, precursors or salts of the invention can be used for assaying the peptides, precursors or salts of the invention in test solutions. The peptides, precursors or salts of the invention are useful as reagents for screening for compounds, or salts thereof, capable of modifying the binding of the peptides, precursors or salts of the invention to certain receptors.

The invention relates to a dietetic therapy meal auxiliary or meal replacement product for gastric ulcer and duodenal ulcer. The main components and a preparation method are as below: first conducting superfine grinding on chicken's gizzard membrane, cape jasmine, a honeysuckle decoction, a kiwi fruit powder, pine pollen, a fingered citron powder, lily, processed licorice, clove and litchi into a powder, and adding a coix seed powder, a Poria powder, a wheat germ powder, a Chinese yam powder and a walnut powder; or decocting the materials with water, filtering the decoction and spraying a filtrate into the coix seed powder, the Poria powder, the wheat germ powder, the Chinese yam powder and the walnut powder; conducting high temperature slaking on the mixture; adding xylo oligosaccharide, a Lactobacillus acidophilus powder, a bifidobacterium powder, a natto powder, a yeast powder, an L-arabinose powder and a spirulina powder; mixing uniformly; and conducting subpackaging. The invention employs reasonable compatibility of materials which are used as both food and medicine and utilizes the principle of balance constitution in traditional Chinese medicine, so that the human body can restore balance and achieve the stable state of health through diet. The product reduces incidence of diseases related to gastric ulcer and duodenal ulcer physique and has the advanategs of safety, effectiveness, little toxic or side effect, common food as the main raw materials, low price and easiness for people to accept.

The invention provides a combination medicament of ilaprazole sodium. The medicament is characterized by comprising the following raw materials in percentage by weight: 5-10 percent of ilaprazole sodium, 25-35 percent of reduction composition containing glutathione and tiopronin with a weight ratio of 1:10 and 45-55 percent of diammonium glycyrrhizinate. The invention also provides a preparation process of the medicament. According to a pharmaceutically acceptable dosage of the ilaprazole sodium, the combination medicament can be respectively prepared into medical preparations of the dosage forms of injections of the combination medicament of the ilaprazole sodium, freeze-drying injections of combination medicament of the ilaprazole sodium, coated tablets of the combination medicament of the ilaprazole sodium, enteric capsules, sprays, and the like and is used for treating gastric ulcer.

The novel positively charged prodrugs of acetylsalicylic acid and its analogues in the general formula(1) 'Structure 1' were designed and synthesized. The compounds of the general formula(1) 'Structure 1' indicated above can be prepared from functional derivatives of ASA or its analogues,(for example acid halides or mixed anhydrides), by reaction with suitable alcohols, thiols, or amines. The positively charged amino groups of these pro-drugs not only largely increases the solubility of the drugs, but also bonds to the negative charge on the phosphate head group of membranes and push the pro-drug into the cytosol. The experiment results suggest that the pro-drug, diethylaminoethyl acetylsalicylate.AcOH, diffuses through human skin -400 times faster than acetylsalicylic acid itself and -100 times faster than ethyl acetylsalicylate. In plasma, 80% of these pro-drugs can change back to the drug in a few minutes. The pro-drugs can be used medicinally in treating any aspirin-treatable conditions in humans or animals and be administered not only orally, but also transdermally for any kind of medical treatments and avoid most of the side effects of aspirin, most notably GI disturbances such as dyspepsia, gastroduodenal bleeding, gastric ulcerations, and gastritis. Controlled transdermal administration systems of the prodrug enable the aspirin in the blood to reach constantly optimal therapeutic blood levels to increase effectiveness and reduce the side effects of aspirin.

The invention discloses an application of a herba schizonepetae-radix saposhnikoviae preparation in preparation of gastric ulcer treatment medicines and a preparation method of the herba schizonepetae-radix saposhnikoviae preparation, and belongs to the field of medicines. The herba schizonepetae-radix saposhnikoviae preparation is prepared from 11 raw medicinal materials including herba schizonepetae, radix saposhnikoviae, notopterygium root, doubleteeth pubescent angelica root, Chinese thorowax root, common hogfenneI root, szechuan lovage rhizome, fructus aurantii, poria cocos, platycodon grandiflorum and liquoric root and has the effects of inducing sweat, dispelling exogenous evils, dispelling wind and eliminating dampness. The herba schizonepetae-radix saposhnikoviae preparation can effectively treat stress gastric ulcer and acetic acid induced chronic gastric ulcer, inhibit gastric acid secretion and reduce free acid and total acidity in gastric juice, has the effect of reducingpepsase activity, treats both symptoms and root causes, and has an exact treatment effect on gastric ulcer.

The invention provides six cyclic dipeptides used for wound healing. The cyclic dipeptide is one of pro-phe, pro-pro, pro-val, pro-his, pro-tyr and pro-gly. The cyclic dipeptide has remarkable therapeutic effect on wound. Inhibition rate of acute and chronic gastric ulcer is high, wound healing speed of burns and scalds is fast, and scars are shallow.

The invention relates to a traditional Chinese medicine combination for curing gastric diseases and a preparation method thereof, which solve the problem that the original traditional Chinese combinations for curing gastric diseases do not have prominent effects and have high recurrence rate. The medicine combination is prepared by corydalis tuber, Chinaberry fruit, turmeric root tuber, evodia rutaecarpa, coptis chinensis, villous amomum fruit, costus root, radix linderae, rhizoma cyperi, frankincense, myrrh and cuttlebone. The traditional Chinese medicine combination has the functions of soothing the liver and regulating vital energy, removing heat from the liver, promoting blood circulation to arrest pain, promoting wound healing and granulation, and can be used for curing gastric and duodenal ulcer, gastritis, stomachache, salivation and sour regurgitation, nausea, retching, epigastric distension and depression; besides, the traditional Chinese combination has special curative effects on gastric ulcer and duodenal ulcer and has inhibiting effect on helicobacter pylori.

The invention discloses flavored fermented soybean chilli sauce. In parts by weight, the flavored fermented soybean pepper sauce is prepared by 105-125 parts of chilli powder, 135-155 parts of colza oil, 25-45 parts of fermented soybeans, 10-30 parts of walnut kernels, 20-40 parts of edible salt, 5-25 parts of garlic, 5-25 parts of gingers, 1-5 parts of pepper and 0.8-1.4 part of white granulated sugar. According to the flavored fermented soybean chilli sauce, the fermented soybeans, the walnuts and the chilli powder are combined, the fermented soybeans are capable of restraining the secretion of gastric acid and activating the secretion of alkaline grume, the chilli powder contains a large amount of vitamin C and the walnuts have the functions of refreshing and nourishing the brain, and in the eating process, the fragrance of the fermented soybeans and the crisp of the walnuts can be tasted, so that the taste of the chilli sauce is greatly improved and the function of preventing and treating gastric ulcer can be provided.

The invention relates to a dissolving ultrafiltration-spray drying-molecule dispersion coating-hydration palletizing-freeze drying method, which can industrially prepare both liposome medicine-carrying injections and liposome medicine-carrying oral preparations by utilizing uniform prescriptions, technologies and devices. The invention provides a mole-ratio prescription of various components and materials for preparing liposome medicine-carrying preparations, and provides a technology for preparing nanoliposome lyophilization injections and liposome oral preparations. The invention also provides 20 embodiments for preparing liposome medicine-carrying preparations: an embodiment for preparing anti-gastric-ulcer liposome medicine-carrying preparations, an embodiment for preparing antibiosis and anti-fungus liposome medicine-carrying preparations, an embodiment for preparing anti-tumor liposome medicine-carrying preparations, an embodiment for preparing anti-viral liposome medicine-carrying preparations, an embodiment for preparing anti-emetic liposome medicine-carrying preparations, an embodiment for preparing nutrition-supplement liposome medicine-carrying preparations and an embodiment for preparing anti-diabetics and cardio- and cerebro-vascular drug liposome medicine-carrying preparations.

A Chinese medicine for treating gastric ulcer and duodenal ulcer is prepared from 19 Chinese-medicinal materials including Cyprus tuber, pilose asiabell root, yam, dandelion herb, etc.

The invention discloses a solid dispersion containing glycyrrhetinic acid 30-amide derivative active component and a preparation method thereof. The solid dispersion consists of active components and carrier materials with the weight percentage of 1: 0.5 to 1: 50. The preparation method can adopt one of the following methods: melting method, solvent method, melting-solvent method, grinding method, spray drying method or freeze-drying method. The solid dispersion can form the medical combination with one or more pharmaceutical acceptable carriers, excipient or diluents; the invention is applied in treatments of anti-inflammatory, anti-gastric ulcer, anti-colitis, analgesia, anti-tussive, liver protection and so on.

The invention discloses monooxygenase. An amino acid sequence of the monooxygenase is obtained through mutation of an amino acid sequence represented by SEQ ID NO:2. The monooxygenase is used for preparing chiral sulfoxide drugs, has the advantages of mild reaction conditions, environmental friendliness, high yield and product optical purity, few peroxidation products and the like and has very good industrial application prospects in production of a drug proton pump inhibitor for treating gastric ulcer.