14 results about "Gastric ulcerations" patented technology

Helicobacter pylori (HP) is a chronic bacterium that infects the gastric mucosa. It is widespread in the general population, with an infection rate between 55% and 70%. HP is closely related to gastric ulcers and gastritis. Western medicine treatment for HP infection is relatively complex, including bismuth substituents and proton pump inhibitors plus two antibiotics. Gastric ulcers and gastritis are common digestive system diseases. Compound 1, "Exterminate the Ghost," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Scutellaria baicalensis and Fraxinus chinensis, which can eradicate HP. Compound 2, "Ulcer Relief," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Rheum palmatum and Bletilla striata, which can cure gastric ulcers. Compound 3, "Gasitis Relief," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Glycyrrhiza uralensis or Taraxacum mongolicum, made into a tea bag, which can cure chronic gastritis.

The application discloses a stomach-derived limosilactobacillus fermentum LAF-09 and application thereof, and the preservation number of the stomach-derived limosilactobacillus fermentum LAF-09 is GDMCC No. 65656. The inventor of the application screens a stomach-derived limosilactobacillus fermentum LAF-09 from stomach mucosa tissue of healthy people, the strain has strong acid resistance and high proliferation capacity in the stomach, has strong adhesion properties to stomach epithelial GSE-1 cells, can be effectively applied to prevent and treat gastric ulcers caused by indomethacin, and has no obvious side effects.

The application provides a compound extract for treating gastric ulcer, a preparation method and application thereof, and belongs to the technical field of medicines. The compound extract is obtained by using medicinal materials of pachouli and high kankyo through an ethanol degreasing, water extraction and alcohol precipitation process. The application has the advantages of few medicinal materials, simple extraction and preparation process and easy industrialization. Animal efficacy and mechanism researches show that the compound extract can protect the gastric mucosal barrier by synergistically improving the function of the mitochondrial electron transport chain and enhancing the antioxidant stress capacity, and can effectively prevent and treat gastric ulcer.

This invention provides the application of *Bifidobacterium breve* in the preparation of products for treating gastric ulcers and gastric inflammation caused by *Helicobacter pylori*, belonging to the field of microbial technology. The *Bifidobacterium breve* NKU BB1-2 of this invention, with accession number GDMCC NO: 65956, can antagonize *Helicobacter pylori* colonization and alleviate the aggravation of gastric ulcers caused by *Helicobacter pylori*. In vitro, *Bifidobacterium breve* NKU BB1-2 exhibits good antagonistic ability against *Helicobacter pylori*, significantly inhibiting its colonization and growth. Animal experiments show that *Bifidobacterium breve* NKU BB1-2 can alleviate the aggravation of gastric ulcers caused by *Helicobacter pylori* infection in vivo, manifested as reduced gastric mucosal damage, reduced gastric inflammation, and increased gastric pH. Furthermore, *Bifidobacterium breve* NKU BB1-2 can significantly enhance gastric microbial diversity, regulate and improve the gastric microbial structure, and assist in antagonizing and eradicating *Helicobacter pylori* infection.

This invention relates to the extraction method and application of total extracts and compositions of *Helicobacter pylori* (Northern Green Dragon Leaf) medicinal materials, belonging to the field of traditional Chinese medicine extraction and chemical separation. To address the problems of high dependence, addiction, and significant adverse reactions of commonly used clinical anti-Helicobacter pylori drugs, the extraction method is as follows: *Helicobacter pylori* is weighed, soaked in ethanol (volume concentration), extracted, and the extracts are combined, the solvent is recovered, and the mixture is freeze-dried to obtain the total extract of *Helicobacter pylori*. The total extract is dissolved in water, and eluted with 20% ethanol using a chromatographic column to obtain the composition of *Helicobacter pylori*. The total extract and composition of *Helicobacter pylori* are used as active ingredients in drugs for treating *Helicobacter pylori*-positive gastric ulcers. Both exhibit significant antibacterial effects, low dependence and addiction, and no adverse reactions.

The present application relates to the technical field of processing of traditional Chinese medicinal materials, and particularly to a preparation process of calcined oyster shell and application thereof. The preparation process of calcined oyster shell provided by the present application is to freeze-dry the oyster shell after water absorption, so that the water crystal in the oyster shell sublimes to form a porous and loose structure, and then two-stage microwave frequency conversion calcination is adopted to heat and calcine the inside and outside of the oyster shell at the same time, so that the calcined oyster shell with crispness and significant medicinal properties is formed. The preparation process of calcined oyster shell provided by the present application can not only shorten the calcination time and reduce the calcination temperature, but also effectively prevent the conversion of calcium carbonate into calcium oxide to maintain the efficacy. The calcined oyster shell prepared by the process has the advantages of crispness, easy crushing, high calcium carbonate content and high dissolution rate of effective components, and also has a strong anti-ulcer effect, especially a significant therapeutic effect on peptic gastric ulcer.

A composition containing lactoperoxidase and one or more iodized salts is used to treat equine gastric ulcer syndrome.

This invention belongs to the field of novel pharmaceutical uses, and more specifically, relates to the application of cinnabar extract in the preparation of drugs for the prevention and treatment of gastric ulcers. The preparation method of the extract is as follows: Cinnabar is extracted by reflux with a 60%–80% (v / v) ethanol solution. The extracts are combined, evaporated to dryness, and then mixed with water to obtain an extract. The extract is then diluted, adsorbed onto a macroporous resin, and eluted with a 35%–45% (v / v) ethanol solution. The eluent is then evaporated to dryness to obtain the final extract. Experiments show that this extract can significantly reduce gastric mucosal damage in mice, decrease the ulcer index, and increase the ulcer inhibition rate, with effects superior to the positive control drug ranitidine. Its mechanism of action includes reducing inflammatory cell infiltration, decreasing the content of pro-inflammatory factors, pepsin activity, and malondialdehyde content, and increasing antioxidant enzyme activity. This invention provides a new natural drug source for the treatment of gastric ulcers, with a clearly defined active pharmaceutical ingredient and promising clinical application prospects.

The present application relates to the technical field of bioengineering, and particularly relates to a fermented liquid of Gomphrena yatschekii, a fermentation method and application thereof.The present application provides a fermentation method of Gomphrena yatschekii, comprising the following steps: (1) mixing Gomphrena yatschekii with mixed enzymes for enzymolysis, and sterilizing to obtain an enzymolysis liquid of Gomphrena yatschekii; (2) mixing the enzymolysis liquid of Gomphrena yatschekii with a compound microbial agent for fermentation, and filtering and sterilizing after fermentation to obtain a fermented liquid of Gomphrena yatschekii; the compound microbial agent is Lactobacillus plantarum LZU-J-TSL6 and Lactobacillus plantarum LZU-J-QA25.After fermentation by the method, the effective components in Gomphrena yatschekii are fully dissolved, the drug activity is improved and increased, the body can rapidly absorb the drug, inflammation and oxidative stress can be regulated, and gastric ulcer can be resisted.

The application provides a Yunnan white pearl extract for targeting regulation of an HDC / HIS axis, a preparation method and application thereof, and belongs to the technical field of natural medicine active ingredient extraction.The Yunnan white pearl extract comprises at least one of the following: an ethyl acetate part of Yunnan white pearl, a n-butanol part of Yunnan white pearl and a water extraction part of Yunnan white pearl.The application firstly proposes that different active parts (water extraction part, n-butanol part and ethyl acetate part) of Yunnan white pearl all have the effect of inhibiting gastric acid secretion, wherein the acid inhibition effect of the ethyl acetate part is the most obvious, the ethyl acetate part reduces histamine generation by regulating the HDC / HIS axis, thereby reducing H2R-mediated gastric acid secretion, blocking H1R-mediated inflammatory response, and playing a double role to treat gastric ulcer.The application of the Yunnan white pearl extract in developing drugs for treating gastric ulcer improves the economic and medicinal value of Yunnan white pearl.

The application discloses application of a compound containing a condensed heterocyclic structure in preparation of a medicine for preventing or treating gastric ulcer, and relates to the technical field of medicinal chemistry. It is found through a large amount of screening and verification that the compounds 8018-9590, G642-6944, L861-0480 and E844-1779 can significantly reduce ulcer foci, significantly reduce the degree of hemorrhage, and specifically reduce mucosal edema and other core pathological characteristics of gastric ulcer, and the ulcer inhibition rate reaches 50.00%. The application provides a new compound type for screening of a medicine for treating gastric ulcer, and provides an important candidate for development of a new anti-ulcer medicine.

This invention discloses a combination of Western and traditional Chinese medicine for treating gastric ulcers. The combination comprises ① gentamicin (80,000 units / vial) and a combination of gentamicin and a remedy called "Weidele". This combination has anti-inflammatory, laxative, and anti-inflammatory effects when taken orally. It is effective in treating inflammation and is safe to use with an extremely low recurrence rate. Improvement is seen within fifteen days, with no obvious toxic side effects. After approximately ten days of symptomatic treatment with the combination of gentamicin (80,000 units / vial) and remedyle, the condition improved, symptoms disappeared, and a follow-up gastroscopy showed improved lesion absorption. Continued anti-inflammatory treatment and a follow-up gastroscopy at three months were then performed.

This invention discloses a traditional Chinese medicine composition for the prevention and / or treatment of gastric ulcers and / or their complications. By weight, the composition comprises: 2-6 parts of Atractylodes lancea, 2-6 parts of Poria cocos, 1-4 parts of Magnolia officinalis, 2-6 parts of Aucklandia lappa, 1-4 parts of Lindera strychnifolia, 1-4 parts of Cyperus rotundus, 1-4 parts of Alpinia officinarum, 1-4 parts of Amomum villosum, 1-4 parts of Coix lacryma-jobi, 1-4 parts of Citrus reticulata peel, 1-4 parts of Citrus medica, 1-4 parts of Crataegus pinnatifida, 1-4 parts of Massa fermentata, 1-4 parts of Hordeum vulgare, 1-4 parts of Gallus gallus domesticus gizzard lining, 1-4 parts of Bletilla striata, 2-6 parts of Paeonia lactiflora, 2-6 parts of Corydalis yanhusuo, 1-4 parts of Cinnamomum cassia, and 1-4 parts of Piper longum. The complications are selected from one or more of the following: pain, inflammation, and delayed gastric emptying. This traditional Chinese medicine composition is safe, effective, and has a simple and efficient preparation method with controllable quality. It exhibits significant anti-inflammatory, analgesic, and gastric motility-promoting effects, and can reduce the colonization of Helicobacter pylori in the stomach. It also has significant therapeutic effects on gastric ulcers induced by different factors (Helicobacter pylori infection, pyloric ligation, and nonsteroidal anti-inflammatory drugs).

This invention belongs to the field of functional beverage technology, and discloses the preparation of a micronutrient-rich functional beverage and its application in accelerating the repair of gastric ulcers. This functional beverage is rich in trace elements and has a pleasant flavor. It not only meets the body's needs for trace elements and supplements substances such as taurine, vitamins, and amino acids, but also accelerates the healing of gastric ulcers by promoting the repair and regeneration of the gastric mucosa. This organic micronutrient-rich functional beverage will help improve the healing effect for patients with gastric ulcers and enhance their quality of life.