Use of sesquiterpenoids having the structures of formula (I) and formula (П) in relieving
nausea and
vomiting. The sesquiterpenoids having the structures of formula (I) and formula (П) are
cedrol and analogs, racemates, stereoisomers, tautomers, isotopically labeled compounds, solvates, polymorphs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof, wherein R 1 to R 8 are as described in the claims and the description. The compounds having the structures of formula (I) and formula (П) can reduce kaolin intake in pica rats, significantly alleviate the symptoms of
nausea and
vomiting induced by
chemotherapeutic drugs such as
cisplatin when used in tumor treatment, and can also relieve
vomiting caused by
gastrointestinal injury, inflammatory diseases,
anorexia, etc. In addition, the compounds having the structures of formula (I) and formula (П) can also be used in the preparation of drugs for relieving / treating
nausea and vomiting or in the preparation of foods for assisting in protecting the
gastric mucosa.