76 results about "Stomach mucosa" patented technology

The invention belongs to the technical field of bioengineering, and particularly relates to leuconostoc mesenteroides subsp. Mesenteroides FTCM002 and application thereof in preparation of dendrobium officinale leavening with the effects of reducing blood sugar, nourishing the stomach and resisting inflammation. Dendrobium officinale is subjected to enzymolysis and inoculated with the strain for fermentation, and the obtained fermented dendrobium officinale has the effect of inhibiting alpha-glucosidase; the gastric mucosal injury can be relieved, the expression of VEGF, IL-6, IL-8 and TNF-alpha in the gastric mucosal injury is reduced, and the effect of nourishing the stomach is achieved; the cell phagocytic rate can be increased, the NO concentration and the content of immune factors IL-6 and TNF-alpha can be increased, and the effect of enhancing the immunity is achieved; the expression quantity of IL-6, IL-1beta and TNF-alpha in inflammatory cells can be reduced, and the anti-inflammatory effect is achieved.

The invention discloses a Pediococcus pentosaceus (Pediococcus pentosaceus, PP) strain, the Pediococcus pentosaceus is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.24884. The Pediococcus pentosaceus has the advantages that the Pediococcus pentosaceus can be used for preparing the Pediococcus pentosaceus; the strain has a good antibacterial effect on helicobacter pylori; the composition is friendly to normal gastric mucosa cells and does not have an inhibition effect; the compound has an obvious inhibiting effect on the growth of gastric cancer and can be used for preventing or treating gastric cancer.

The invention relates to the technical field of medicines, in particular to a pharmaceutical composition for improving acute alcoholic gastric mucosal lesion and application. The invention discloses the new medical application of the lucid ganoderma, ginseng and kudzuvine root formula for the first time, and experiments and clinical verifications prove that the formula can increase the activity of key enzymes in stomach and liver tissues of a mouse with acute alcoholic gastric mucosal injury, reduce the content of a proinflammatory factor TNF-alpha in the stomach tissues, increase the generation of an anti-inflammatory factor IL-10 in the stomach tissues, relieve the inflammatory injury of ethanol to gastric mucosa, improve the curative effect of alcohol on the gastric mucosa and improve the curative effect of alcohol on the gastric mucosa. The levels of protective factors EGF, SS and PGE-2 in serum are increased, the defense mechanism of gastric mucosa is enhanced, and the repairing capacity of the gastric mucosa is improved. The discovery has great influence on the research and treatment of acute alcoholic gastric mucosal injury diseases, and has clinical practical value.

A composition is described comprising a mixture of at least one cetylated fatty acid or a mixture of cetylated fatty acids and an antioxidant in reduced percentages by weight, and related methods for treatment of arthritis and of inflammatory joint and musculoskeletal pain. Furthermore composition is described comprising a mixture of at least one cetylated fatty acid or a mixture of cetylated fatty acids and, optionally, an antioxidant, and related treatment methods for protecting the gastric mucosa and for regulating the blood glucose levels. Additionally, a method is described for preparing the at least one cetylated fatty acid or mixture of cetylated fatty acids and for preparing compositions comprising the cetylated fatty acids and the antioxidant.

A composition is described comprising a mixture of at least one cetylated fatty acid or a mixture of cetylated fatty acids and an antioxidant in reduced percentages by weight, and related methods for treatment of arthritis and of inflammatory joint and musculoskeletal pain. Furthermore a composition is described comprising a mixture of at least one cetylated fatty acid or a mixture of cetylated fatty acids and, optionally, an antioxidant, and related treatment methods for protecting the gastric mucosa and for regulating the blood glucose levels. Additionally, a method is described for preparing the at least one cetylated fatty acid or mixture of cetylated fatty acids and for preparing compositions comprising the cetylated fatty acids and the antioxidant.

The invention relates to the technical field of computer vision and medical image processing, and discloses a digestive endoscopy report generation method and device based on a multi-modal large language model. The method specifically comprises the following steps: for a plurality of upper gastrointestinal endoscopy images, extracting a first image feature through a visual encoder to perform anatomical part identification; extracting a second image feature from the first image feature by using a self-attention mechanism to perform background gastric mucosa classification; generating description about digestive tract diseases through a large language model, and under the guidance of the description, extracting third image features from the first image features to perform digestive tract disease classification; the constructed text instruction about report generation and the third image feature are combined and then input into a multi-mode decoder, and a digestive endoscopy report is generated. According to the method, a plurality of upper gastrointestinal endoscopy image analysis tasks can be processed at the same time, and a digestive endoscopy report which does not depend on a fixed template and has rich context content can be generated with high efficiency and high accuracy.

The invention belongs to the technical field of application of natural products, and particularly relates to an anti-helicobacter pylori natural product composition and application, the anti-helicobacter pylori natural product composition comprises raspberry extract and cinnamon extract, and the composition contains anti-helicobacter pylori active substances. Besides, the natural product composition is combined with a clinical standard treatment method for treating helicobacter pylori, so that the curative effect can be further improved, and the gastrointestinal motility can be enhanced by adjusting intestinal flora disorder caused by pylorus infection, reducing toxic and side effects of antibiotic treatment, protecting gastric mucosa and enhancing gastrointestinal motility. The composition consists of two natural medicinal and edible plant extracts, is suitable for long-term use and has few adverse reactions. The Lycojaponicumin C can be used for preparing anti-helicobacter pylori medicines and preventive health-care foods, has obvious significance in prevention and treatment of helicobacter pylori infection, and has a good development prospect.

The present invention discloses a repair functional composition HAmella containing sodium hyaluronate and tremella polysaccharide, belonging to the field of biomedical technology. The preparation method includes: mixing sodium hyaluronate and tremella polysaccharide, dissolving them in water to prepare a polysaccharide aqueous solution; wherein, the molecular weight of the sodium hyaluronate is 100 - 300 KD, and the molecular weight of the tremella polysaccharide is 50 - 200 KD; dissolving saponin in water to prepare an aqueous phase, and then adding camellia oil to the aqueous phase to prepare a camellia oil microemulsion; mixing the polysaccharide aqueous solution and the camellia oil microemulsion evenly, and spray drying to obtain a gastric mucosa protectant. The preparation method of the protectant of the present invention is simple, shows excellent performance in gastrointestinal protection, and has an injury inhibition rate of about 50% in an ethanol-induced gastric ulcer model.

The invention belongs to the field of traditional Chinese medicines, and provides application of a watermelon frost and periplaneta americana composition in preparation of a medicine for treating gastric ulcer caused by helicobacter pylori. The invention provides an application of a mirabilitum praeparatum and periplaneta americana composition in treatment of gastric ulcer, the composition has an effect of inhibiting and killing helicobacter pylori in vitro, and has a good synergistic effect in a specific proportion; the composition can reduce the ulcer index of a gastric ulcer model rat, and has good effects of protecting gastric mucosa and improving gastric ulcer; compared with a control Chinese patent medicine, the medicament prepared from the composition can improve the effective rate of helicobacter pylori induced gastric ulcer and the HP eradication rate. The invention provides a novel pharmaceutical composition for helicobacter pylori induced gastric ulcer, and the pharmaceutical composition is high in safety and few in side effect.

The invention provides application of pinocembrin in preparation of a medicine for treating gastric ulcer, and belongs to the technical field of medicines. The invention aims to provide the application of the pinocembrin as a unique active ingredient in preparation of the medicine for treating gastric ulcer, and the pinocembrin as the medicine for treating gastric ulcer can reduce the ET-1 content in plasma of rats suffering from gastric ulcer caused by absolute ethyl alcohol, increase the NO content and enhance the repairing effect of gastric mucosa; the contents of TNF-alpha and IL-6 are reduced, and the content of IL-10 is increased; the content of T-SOD in plasma is increased, the content of MPO is reduced, and the antioxidant effect is enhanced. Therefore, the pinocembrin has a remarkable treatment effect on the rat gastric ulcer caused by the absolute ethyl alcohol.

The invention relates to the technical field of microorganisms, and particularly discloses a lactobacillus plantarum R202448 and application thereof in resisting helicobacter pylori, the lactobacillus plantarum R202448 is preserved in China General Microbiological Culture Collection Center on June 27, 2025, and the preservation number is CGMCC NO. The lactobacillus plantarum is located in Institute of Microbiology, Chinese Academy of Sciences, No.3, No.1 Yard, West Beichen Road, Chaoyang District, Beijing, has a preservation number of CGMCCNO: 31101, and is classified and named as lactobacillus plantarum R202448. According to the plant lactobacillus R202448 and the metabolite thereof disclosed by the invention, on the basis of inhibiting an H.pylori biological membrane and reducing the activity of the H.pylori, the damage and apoptosis promoting effects of the H.pylori on gastric mucosa epithelial cells can be effectively inhibited, so that the occurrence of the H.pylori is effectively inhibited, and the functions of the gastric mucosa epithelial cells are protected.

The invention relates to a new application of early-stage chick embryo amniotic fluid, which is characterized in that the early-stage chick embryo amniotic fluid is found to be capable of effectively dispelling the effects of alcohol, removing the content of ethanol in serum and increasing the levels of liver acetaldehyde dehydrogenase and ethanol dehydrogenase by evaluating the effect of dispelling the effects of alcohol of the early-stage chick embryo amniotic fluid, and also has the effects of protecting the gastric mucosa function and the like.

The application discloses a stomach-derived limosilactobacillus fermentum LAF-09 and application thereof, and the preservation number of the stomach-derived limosilactobacillus fermentum LAF-09 is GDMCC No. 65656. The inventor of the application screens a stomach-derived limosilactobacillus fermentum LAF-09 from stomach mucosa tissue of healthy people, the strain has strong acid resistance and high proliferation capacity in the stomach, has strong adhesion properties to stomach epithelial GSE-1 cells, can be effectively applied to prevent and treat gastric ulcers caused by indomethacin, and has no obvious side effects.

The invention discloses a gastric mucosa repairing composition based on cuttlebone and oxhide gelatin and a preparation method of the gastric mucosa repairing composition. The gastric mucosa repairing composition comprises cuttlebone active components, modified oxhide gelatin and probiotics, the cuttlebone active component comprises nano-scale particles; the modified oxhide gelatin is a porous scaffold material subjected to genipin crosslinking treatment; the probiotics comprise lactobacillus reuteri and bifidobacterium. According to the application, through the compounding of the nanocrystallized cuttlebone active component, the genipin cross-linked and modified porous oxhide gelatin scaffold, the specific probiotics and the licorice total flavonoids, a multi-dimensional synergistic repair system is adopted, nano-calcium can quickly neutralize gastric acid and locally stop bleeding, cuttlebone polysaccharide and active peptide can up-regulate expression of growth factors such as EGF and VEGF, and the effect of stopping bleeding is achieved. Proliferation and migration of epithelial cells and fibroblasts are directly driven; the modified oxhide gelatin forms a stable bionic adhesive protective film, and the stable bionic adhesive protective film is used as a three-dimensional scaffold to guide cells to crawl.

The present invention discloses the use of the Prosaposin gene / protein, belonging to the technical field of cancer precision medicine drugs. Through experiments such as ELISA and multi-color immunofluorescence, the present invention has confirmed that the Prosaposin protein is expressed in the blood and cancer tissues of gastric cancer patients, significantly higher than its expression in the blood of healthy people and benign gastric mucosa tissues, and the prognosis of patients with high expression of the Prosaposin protein is poor. The Prosaposin gene / protein is a target for precision therapy, and a targeted drug for treating diseases with high expression of the Prosaposin gene / protein such as gastric cancer, and a kit for diagnosis or prognosis judgment are prepared. The CRISPR-Cas9 system of the present invention can efficiently knock out the Prosaposin gene overexpressed in gastric cancer, inhibit the proliferation, invasion and migration of gastric cancer cells, and the system is simple to operate and has a high knockout efficiency. Therefore, the present invention has good application prospects.

The invention relates to a proteolysis product with gastric mucosa repair activity and application thereof. The protein zymolyte with gastric mucosa repair activity is prepared by the following method: firstly, carrying out primary enzymolysis on mycoprotein by using a first enzyme to obtain a primary enzymolysis solution, and then carrying out secondary enzymolysis on the primary enzymolysis solution by using a second enzyme to obtain a secondary enzymolysis solution, the secondary enzymatic hydrolysate is a solution in which the protein hydrolysate with gastric mucosa repair activity is dispersed; the first enzyme comprises aspergillus oryzae protease; the second enzyme comprises aspergillus niger lipase. The proteolysis product provided by the invention has the effects of increasing the antioxidant level of gastric tissues, improving the defense factor level of gastric mucosa and reducing the level of related inflammatory factors in serum, can play a role in protecting the gastric mucosa, has gastric mucosa repairing activity, and is safe and easily available in raw materials, simple in preparation method and easy for batch production.

The present application relates to the technical field of medicine, in particular to a kind of drug composition for improving acute alcoholic gastric mucosal injury and application.The present application discloses the new medical use of ganoherbae decoction for the first time, and the composition can increase the activity of key enzyme in the stomach and liver tissue of acute alcoholic gastric mucosal injury mice, reduce the content of pro-inflammatory factor TNF-α in gastric tissue, increase the production of anti-inflammatory factor IL-10 in gastric tissue, reduce the inflammatory damage of ethanol to gastric mucosa, increase the level of protective factor EGF, SS and PGE-2 in serum, enhance the defense mechanism of gastric mucosa, and improve the repair ability of gastric mucosa.The discovery will have a significant impact on the research and treatment of acute alcoholic gastric mucosal injury disease, and has clinical practical value.

The present invention relates to the technical field of emulsification processes, and particularly to the production process of camellia oil emulsification; it includes the following steps: Step 1: Mix tapioca starch and water to obtain a starch milk; Step 2: Add glucoamylase and α-amylase to the starch milk, add Bacillus firmus for fermentation reaction, after the reaction, inactivate Bacillus firmus, glucoamylase, and α-amylase to obtain a fermentation product; Step 3: Mix the fermentation product, camellia oil, sorbitan monostearate, L-ascorbic acid palmitate, cocoa butter, water, and lecithin according to the mass ratio to obtain a mixture, heat the mixture to 40-45 °C, adjust the pH to 6-8, and circulate and process it 3-5 times under a pressure of 90-100 MPa through a high-pressure homogenizer to obtain a homogeneous emulsion. The prepared camellia oil emulsification product can still maintain a good effect on gastric mucosa repair after being stored under indoor light conditions at room temperature for more than 24 months.

The utility model relates to the technical field of medical apparatus and instruments, in particular to a detection sampling device for atrophic gastritis, which comprises a sleeve and a sampling component, an arc-shaped plate is connected to the outer side of the sleeve in a hot melting manner, a metal hose is fixedly connected to the bottom of the arc-shaped plate through a bolt, a connecting rod is sleeved at the top end of the sleeve, and the sampling component is connected with the connecting rod. A steel wire is fixed at the bottom end of the connecting rod through a bolt; a sampling assembly is arranged at one end of the metal hose and comprises an arc-shaped umbrella cover welded to one end of the steel wire and a column sleeve welded to one end of the metal hose, and grooves are formed in the outer side of the column sleeve at equal intervals; after the sampling assembly is inserted into the stomach of a patient, the rotating column sleeve makes contact with the interior of the stomach, so that gastric mucosa fluid makes contact with and adheres to the interior of the groove, the gastric mucosa fluid is sampled, the arc-shaped umbrella cover is pulled through the steel wire, the arc-shaped umbrella cover moves to scrape gastric mucosa tissue, and the gastric mucosa tissue is sampled.

The invention discloses micro-plastic adsorption chewing gum for a digestive system and a preparation method thereof.The chewing gum comprises an oral cavity adsorption layer, a transition protection layer, an intestinal tract stabilizing layer and a bionic gastric mucosa core layer which are sequentially arranged from outside to inside, and the oral cavity adsorption layer is a film prepared from chitosan microspheres, gutta-percha and nano activated carbon; the transition protection layer is a film prepared from a hydroxypropyl methylcellulose phthalate ethanol solution, the intestinal tract stabilizing layer is a film prepared from PLGA and dichloromethane, and the bionic gastric mucosa core layer is an elastic film prepared from silicone rubber and aluminum hydroxide micro powder. Through the triple design of time-controlled dissolution of the transition layer, mechanical locking of the gum-based grid and physical bottom wrapping of the core layer, it can be ensured that microplastics adsorbed by the oral cavity layer are not released again even though the oral cavity layer is dissolved in the stomach, and the whole process from the oral cavity to discharge is safe.

The invention discloses application of a nutritional composition in preparation of products for protecting or repairing gastric mucos.The nutritional composition comprises 5%-10% of bitter gourd seed basic protein, 5%-10% of fish elastin peptide powder and 80%-90% of yeast glucan, the nutritional composition can synergistically inhibit expression of IL-1beta, IL-6 and TNF-alpha inflammatory factors, the structural safety of the stomach wall is protected, and the effect of protecting or repairing the gastric mucosa is achieved. The composition can repair gastric mucosal injury, and especially has a remarkable effect on preventing the gastric mucosal injury.

The invention provides application of hippophae rhamnoides extract in preparation of a product for dispelling the effects of alcohol or preventing and treating visceral organ injury caused by drinking, and belongs to the technical field of biological medicine. The invention provides application of a sea-buckthorn extract or a product containing the sea-buckthorn extract in preparation of a product for dispelling the effects of alcohol or preventing and treating visceral organ injury caused by drinking. The sea-buckthorn extract comprises sea-buckthorn fruit oil, sea-buckthorn seed oil and / or sea-buckthorn fruit pulp. The organ injury comprises alcoholic fatty liver, gastric mucosa injury or duodenum mucosa injury. The hippophae rhamnoides fruit extract (hippophae rhamnoides fruit pulp, hippophae rhamnoides fruit oil and hippophae rhamnoides fruit seed oil) and the hippophae rhamnoides fruit and Chinese wolfberry fruit composite primary pulp provided by the invention have the effects of promoting the repair of gastric mucosa and duodenal mucosa and further enhancing the immunity of gastrointestinal tracts, and can effectively prevent and / or treat gastritis, alcoholic fatty liver and duodenal mucosa injury caused by drinking; the traditional Chinese medicine composition can replace traditional medicine treatment and has the advantages of small side effect, economy, practicability, suitability for long-term administration and good compliance.

The invention provides a sauce for promoting gastrointestinal health as well as a preparation method and application thereof, and relates to the technical field of food processing. The sauce comprises the following components in parts by weight: 20-40 parts of codonopsis pilosula, 15-30 parts of poria cocos, 7-10 parts of astragalus membranaceus, 7-10 parts of white hyacinth bean, 8-12 parts of bighead atractylodes rhizome, 5-8 parts of hawthorn, 8-12 parts of liquorice, 1-6 parts of cinnamon, 1-6 parts of cinnamon, 1-6 parts of star anise, 15-20 parts of rice vinegar, 15-20 parts of rice wine, 3-8 parts of table salt, 3-8 parts of white granulated sugar, 3-8 parts of chicken essence and 3-8 parts of monosodium glutamate. The sauce does not contain preservatives, is green and safe, also has better effects of improving immunity, promoting growth of intestinal probiotics and protecting gastric mucosa, can promote gastrointestinal health, and is suitable for long-term eating.

The invention discloses a traditional Chinese medicine formula for treating atrophic gastritis with intestinal metaplasia and atypical hyperplasia and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine formulas. The traditional Chinese medicine composition comprises the following components in parts by weight: 16-20 parts of Zhejiang radix ophiopogonis, 15-20 parts of moutan bark, 28-32 parts of salvia miltiorrhiza, 10-14 parts of pseudo-ginseng slices, 15-18 parts of curcuma zedoary, 18-22 parts of codonopsis pilosula, 28-32 parts of astragalus membranaceus and 28-32 parts of oldenlandia diffusa. The preparation method comprises the following steps: (1) cleaning the medicinal materials, and then cutting into small blocks to obtain a mixed medicinal material; (3) boiling with big fire after soaking, continuing to decoct with small fire, and filtering to obtain first medicine liquid and medicine residues; and (4) adding water again, boiling with big fire, continuously decocting with small fire, filtering to obtain a second liquid medicine, and mixing the first liquid medicine and the second liquid medicine. The traditional Chinese medicine composition can obviously improve inflammation and atrophic lesion of gastric mucosa, and has a remarkable effect on treating atrophic gastritis with intestinal metaplasia and atypical hyperplasia.

The invention discloses a product capable of forming a gastric mucosa protective layer and a preparation method thereof, and belongs to the technical field of intelligent manufacturing of pharmaceutical preparations. The product is prepared from ginseng, hericium erinaceus, radix angelicae, sesame oil and beewax. The method aims to solve the problems of non-uniform product quality and unstable performance caused by fluctuation of active ingredients of natural raw materials and traditional fixed process parameters, and comprises the following steps: on the basis of a standard ratio, detecting the active ingredients, moisture and appearance of the raw materials on line through a near infrared spectrum and an industrial camera, and dynamically calculating and adjusting the actual feeding amount; extracting, concentrating, emulsifying and refining at low temperature under reduced pressure to obtain initial ointment; and then monitoring the particle size, polydispersity index and low shear viscosity of the nano-emulsion particles in real time, executing closed-loop feedback control by a central control system, and dynamically adjusting the nano-dispersion pressure and time until the product reaches a preset fine and uniform state. The method is used for preparing a pasty product capable of rapidly forming a compact protective layer in the stomach, and the batch consistency of the efficacy and the physical property of the pasty product is guaranteed.

The invention relates to a gastric mucosa targeted repair type amino acid preparation as well as a preparation method and application thereof, and the preparation raw materials comprise the following components in parts by weight: 10-30 parts of gelatin, 5-15 parts of L-glutamine, 4-8 parts of an acidity regulator, 0.5-2.5 parts of MMP-9 specific lysis polypeptide, 0.4-0.6 part of gastric mucosa lesion targeted peptide and 3-7 parts of a pH responsive polymer. The pH response type polymer comprises ethyl cellulose and a methylation modified poly (acrylic acid-methyl methacrylate) copolymer. According to the amino acid preparation prepared by compounding the components, the targeted repair performance of the amino acid preparation on the gastric mucosal lesion part can be efficiently improved.

The present invention belongs to the field of biomedical technology, and specifically relates to a kind of wax gourd peel polysaccharide and its application. For the first time, the crude wax gourd peel polysaccharide obtained by the water extraction and alcohol precipitation method is decontaminated, separated and purified to obtain the wax gourd peel polysaccharide with a repeating unit structure. The said wax gourd peel polysaccharide is mainly composed of galactose, galacturonic acid, rhamnose, arabinose and glucose, and the total sugar content is ≥90%. In vitro and in vivo experiments prove that the wax gourd peel polysaccharide of the present invention has excellent gastric mucosa protection effect, and has good application prospects in the preparation of drugs for preventing and treating gastric ulcers or health products or feeds with the function of assisting in protecting the gastric mucosa.

The invention relates to the technical field of microorganisms, and discloses a plant lactobacillus XJSN202504 and application thereof in acute alcoholism, the plant lactobacillus XJSN202504 is preserved in China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC NO.34746, and the preservation time is June 3, 2025. The invention further discloses a preparation method of the plant lactobacillus XJSN202504. The lactobacillus plantarum XJSN202504 disclosed by the invention can be used for improving liver injury related indexes in serum and expression of inflammation related genes, and also can be used for adjusting the activity of antioxidant enzymes in the liver and relieving alcohol-induced oxidative stress injury; moreover, gastric mucosa, small intestine and colon injuries caused by a large amount of alcohol can be effectively prevented, the anti-inflammatory activity and the antioxidant activity are better, the anti-alcohol function can be achieved through gastrointestinal tracts, and the effects of protecting liver and digestive tract mucosa are achieved.

The invention relates to the technical field of platycodon grandiflorum preparation, in particular to a black platycodon grandiflorum composite concentrated solution as well as a preparation method and application thereof. The preparation method comprises the following steps: steaming fresh platycodon grandiflorum, drying after steaming, and steaming and drying for 9 times in total to obtain black platycodon grandiflorum; the preparation method comprises the following steps: mixing black platycodon grandiflorum with water, carrying out water extraction, and concentrating the extract liquid after water extraction to obtain the black platycodon grandiflorum extract. Fresh platycodon grandiflorum is steamed and dried for nine times, part of saponin is hydrolyzed and converted into secondary sapogenin which is more easily absorbed by a human body, meanwhile, effective components are highly concentrated, the black platycodon grandiflorum with an excellent effect is prepared, the black platycodon grandiflorum is prepared into the black platycodon grandiflorum concentrated solution, the taste of the black platycodon grandiflorum can be improved, and the black platycodon grandiflorum has the effects of improving the immunity of the human body and improving the immunity of the human body. In-vivo and in-vitro experiments show that the black platycodon grandiflorum concentrated solution provided by the invention has the effects of improving gastric ulcer and protecting gastric mucosa.

The application relates to the technical field of veterinary drugs, in particular to a sucralfate tablet and a preparation method thereof. The sucralfate tablet comprises the following components in parts by weight: sucralfate 30-60 parts, a filler 30-60 parts, dextrin 5-20 parts, microcrystalline cellulose 5-20 parts and a lubricant 0.1-0.5 parts, wherein the filler comprises more than 95% of corn starch and not less than 1.5% of an amino acid composition. According to the technical scheme, the amino acid composition is added into the filler in a proper amount, so that the sucralfate tablet can be uniformly dispersed in the stomach, the coverage of the stomach mucosa is improved, and the sucralfate tablet has better treatment and repair effects on gastric ulcers.