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262 results about "Stomach mucosa" patented technology

Lactobacillus acidophilus LA-10A capable of inhibiting helicobacter pylori and application thereof

ActiveCN111118106AReduce or prevent infectionInhibit or eliminate colonizationAntibacterial agentsMilk preparationBiotechnologyMetabolite
The invention provides a method of screening a bacterial strain capable of inhibiting helicobacter pylori. The method includes a way that qualitative and quantitative assessment can be directly conducted on screened bacterial strains if the screened bacterial strains can inhibit or eliminate the colonization of the helicobacter pylori on gastric mucosal cells by utilizing DNA fluorescent labels and flow cytometry. According to the invention, the following points are considered when conducting screening model tests in vitro: (1) viability in an extremely acidic stomach environment; (2) inhibition ability of the bacterial strains itself or metabolites of the bacterial strains to HP reproduction in vitro; and (3) ability of inhibiting or relieving the colonization of the helicobacter pylori strains on gastric mucosa. According to the invention, developing the method of directly assessing in vitro if the HP colonization can be inhibited is of great significance to the practical applicationof the bacterial strain provided by the invention. According to the invention, lactobacillus acidophilus LA-10A capable of inhibiting the helicobacter pylori is screened out. According to a test, thelactobacillus acidophilus LA-10A can relieve or prevent the helicobacter pylori infection. The lactobacillus acidophilus LA-10A can be used to prepare functional food or pharmaceutical compositions.
Owner:THANKCOME BIOLOGICAL SCI & TECH CO LTD

Dendrobium officinale and hericium erinaceus compound chewable tablet and preparation method thereof

ActiveCN103463457ASolve the problem that the drug effect can not fully workFully absorbedAntibacterial agentsAntipyreticCelluloseMethyl cellulose
The invention discloses a dendrobium officinale and hericium erinaceus compound chewable tablet. According to a formula, the dendrobium officinale and hericium erinaceus compound chewable tablet comprises 2 to 10 parts of dendrobium officinale, 10 to 30 parts of hericium erinaceus, 10 to 70 parts of Guangxi dioscorea opposita thunb, 3 to 5 parts of corrective agent, 20 to 30 parts of hydroxypropyl methyl cellulose, 5 to 15 parts of maltodextrin, and 1 to 3 parts of lubricant. The preparation method comprises the following steps: respectively crushing all the raw materials; screening with 500 meshes to obtain submicron powder; combining in proportion as indicated in the formula; uniformly agitating; adding ethyl alcohol to granulate in a wet manner; drying at a temperature of 60 to 80 DEG C until the moisture content is up to 4 to 5% in percentage by weight; cooling to reach room temperature; screening with 60 meshes; adding the lubricant to mix; then performing to obtain the dendrobium officinale and hericium erinaceus compound chewable tablet. The chewable tablet has the health care effects of clearing heat and promoting fluid, protecting gastric mucosa, nourishing both stomach and liver, diminishing inflammation and relieving pain, replenishing Qi and tonifying lung, and regulating lung and reducing phlegm.
Owner:AGRI PROD PROCESSING INST GUANGXI ACADEMY OF AGRI SCI +1

Metformin hydrochloride sustained-release capsule and its preparation method

The invention relates to a metformin hydrochloride sustained-release capsule and its preparation method. The metformin hydrochloride sustained-release capsule is prepared by steps of coating a metformin hydrochloride granule sustained-release material and putting into an enteric capsule. In comparison with the prior art, sustained-release granules and enteric capsule filling technology are combined together to prepare the new dosage form of metformin hydrochloride sustained-release (enteric-coated) capsule. As the sustained-release granule coating and enteric capsule filing technology is adopted, metformin hydrochloride will not be disintegrated and will not stimulates gastric mucosa, and adverse reactions such as nausea, stomachache, diarrhoea and the like caused by medication can be avoided. Meanwhile, metformin hydrochloride will not be damaged by gastric juice, and bioavailability of metformin hydrochloride is raised. In addition, the product provided by the invention is also a sustained-release enteric-coated preparation. The medicine can be stably released in a body, effective plasma concentration is maintained for a long time, and toxic and side effect which might be caused by higher plasma concentration within a short time are avoided. The frequency for taking the medicine is reduced, and patient compliance is also raised.
Owner:BOSEN BIO PHARMA SHANXI PROVINCE

Sodium dichlorophenolate micro-pill pharmaceutical preparation and preparation method thereof

The invention relates to the pharmaceutical preparation field and in particular to a sodium dichlorophenolate micro-pill pharmaceutical preparation and a preparation method thereof. The micro-pill pharmaceutical preparation is prepared by micro-pills, which is characterized in that the micro-pill is of enteric slow-release micro-pill, the micro-pill consists of a hollow pill core, an active layer and an outer layer lagging cover, the active layer comprises sodium dichlorophenolate, a binding-property slow-release material and a binding-property enteric material, and the outer layer comprises a slow-release material. With the particular process and formula, a release system thereof is made into a unique double slow-release system, i.e. a skeleton-type scattering system is combined with a multi-layer semi-penetration film lagging cover system, so the main medicine can be continuously and stably released in the complicated internal environment of the human body. In addition, by adopting unique auxiliary materials, the micro-pill is free from being dissolved in the stomach and almost has no harm on the gastric mucosa, the medicine is ensured to have continuous effect of 24 hours inside the intestinal tract, the bioavailability is improved, and the application effect of the medicine is ensured.
Owner:HANGZHOU SHARPLY PHARM R&D INSTIT +1

Oral liquid for treating chronic atrophic gastritis

The invention belongs to the technical field of traditional Chinese medicines and relates to oral liquid for treating chronic atrophic gastritis. The oral liquid is prepared by the following components in parts by weight: 10 parts of Zhejiang white atractylodes rhizome, 15 parts of poria cocos, 10 parts of orange peel, 10 parts of pinellia tenata breit, 10 parts of vinegar rhizoma cyperi, 10 parts of fructus amomi, 10 parts of mangnolia officinalis, 10 parts of vinegar curcuma aromatic, 15 parts of artemisia anomala, 6 parts of cassia twig, 10 parts of rhizoma corydalis, 10 parts of hawthorn, 10 parts of roasted malt, 10 parts of roasted medicated leaven, 10 parts of lindera aggregate, 15 parts of radix paeoniae alba, 12 parts of radix pseudostellariae and 3 parts of liquorice. The oral liquid provided by the invention has the effects of relieving inflammatory cell infiltration, regulating cellular immunity and humoral immunity function, restraining the activity of pepsinogen to promote proliferation and recovery thereof, strengthening barrier protection function of the mucosa, regulating gastrointestinal motility, increasing permeability of gastric mucosa, improving blood circulation of the mucosa, promoting atrophic glands to recover, and delaying or reversing progression of diseases.
Owner:李郑生

Direct-drinking wall-breaking herbaceous composition capable of quickly relieving symptoms of stomach discomfort and preparation

The invention belongs to the field of food engineering, and particularly relates to a direct-drinking wall-breaking herbaceous composition capable of quickly relieving symptoms of stomach discomfort and preparation. The direct-drinking wall-breaking herbaceous composition consists of 3-10 parts of wall-breaking mixed powder, and 4-8 parts of water-solubility auxiliary materials, wherein the wall-breaking mixed powder consists of fermentation soybean flour, hericium erinaceus wall-breaking powder and vine tea wall-breaking powder in mass ratio of the fermentation soybean flour to the hericium erinaceus wall-breaking powder to the vine tea wall-breaking powder being (1-5) to (1-10) to (1-10), and the particle diameter of the wall-breaking mixed powder is 75[mu]m. The invention discloses a preparation method of the direct-drinking wall-breaking herbaceous composition. The fermentation soybean flour, the hericium erinaceus wall-breaking powder and the vine tea wall-breaking powder in a certain proportion are mixed with the water-solubility auxiliary materials, and granulation is performed by a wet method or a dry method. The direct-drinking wall-breaking herbaceous composition can improve the clinical symptoms of patients suffering from stomach discomfort, and the stomach mucosa is protected. Besides, the direct-drinking wall-breaking herbaceous composition is smooth and creamy inmouth feel, can be taken directly when being swallowed. The micro powder treated through wall breaking can quickly disperse and act on stomachs, and can rapidly improve the stomach discomfort.
Owner:ZHONGSHAN ZHONGZHI PHARMA GRP
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