Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Dexibuprofen amino acid salt injection and preparation method thereof

An amino acid salt, salt injection technology, applied in anti-inflammatory agents, pharmaceutical formulations, non-central analgesics and other directions, can solve problems such as difficulty in the development of solution-type preparations, and achieve the effect of reducing adverse reactions and reducing dosage.

Inactive Publication Date: 2009-11-04
航天中心医院 +1
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology helps prevent or treat pain caused by inflammation without causing any side-effects like those associated with traditional drugs such as naproxyprogesterone acetate (NOP).

Problems solved by technology

This patented technical problem addressed in this patents is how to develop stable injectables containing active ingredients like ibupropfen that provide better results when administering them alone without causing side effects during treatment due to their poor solubility in water.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dexibuprofen amino acid salt injection and preparation method thereof
  • Dexibuprofen amino acid salt injection and preparation method thereof
  • Dexibuprofen amino acid salt injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Prescription: Dexibuprofen arginine salt: 184.45g (calculated as ibuprofen is 100g)

[0035] Sodium bicarbonate: 6g

[0036] Add water for injection to: 1000ml

[0037] Process: Follow the ordinary small-volume injection process. Dissolve the prescribed amount of dexibuprofen arginine salt and sodium bicarbonate with 80% to 90% of the total amount of water for injection, and then add water for injection to the prescribed amount; after adding activated carbon, place the liquid at 70°C to Insulate and stir at 80°C for 15 minutes to fully absorb, then decarburize; use 0.45μm and 0.22μm microporous membranes for fine filtration in turn; determine the content and pass the relevant substances, and then fill it into 1ml or 2ml ampoules that have been washed, dried and sterilized , melt-sealed; sterilized by autoclaving at 115°C for 30 minutes, and the finished product is obtained after passing the light inspection.

Embodiment 2

[0039] Prescription: Dexibuprofen Lysine Salt: 170.87g (calculated as ibuprofen as 100g)

[0040] Sodium bicarbonate: 6g

[0041] Add water for injection to: 1000ml

[0042] Process: follow the small volume injection process. Weigh the prescribed amount of dexibuprofen lysine salt and sodium bicarbonate, add 80% to 90% of the total amount of prescription water for injection to dissolve, then add water for injection to 1000ml; after adding activated carbon, the liquid medicine is placed at 70°C ~80℃, heat preservation and stirring for 15 minutes, after full adsorption, decarbonization; followed by fine filtration with 0.45μm and 0.22μm microporous membranes; measure the content and pass the relevant substances, fill in 1ml or 2ml that has been washed, dried and sterilized In ampoules, sealed by melting; sterilized by autoclaving at 115°C for 30 minutes, and the finished product is obtained after passing the light inspection.

Embodiment 3

[0044] Prescription: Dexibuprofen: 100g

[0045] Arginine: 85g

[0046] Sodium bicarbonate: 6g

[0047] Add water for injection to: 1000ml

[0048] Process: Operate according to the small volume injection process. Weigh the prescribed amount of arginine and sodium bicarbonate and dissolve them with about 800ml of water for injection, then add the prescribed amount of Dexibuprofen under stirring, stir while adding until completely dissolved, then add water for injection to 1000ml; add activated carbon After the liquid medicine is placed at 70°C to 80°C for 15 minutes, it is kept warm and stirred for 15 minutes. Put it into 1ml or 2ml ampoules that have been treated with bacteria, and melt it; sterilize by autoclaving at 115°C for 30 minutes, and get the finished product after passing the light inspection.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a dexibuprofen amino acid salt injection and a preparation method thereof. The method is characterized by taking sodium bicarbonate as an adjuvant of the preparation to provide stable quality, less irritability and no hematolysis to the injection. The injection is mainly used for allaying a fever, easing the pain and resisting inflammation when oral administration is not suitable or is forbidden.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Owner 航天中心医院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com