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Preparation method of 'Xue Fu Zhu Yu' capsule and quality standard thereof

A technology of removing blood stasis from blood and quality standards, applied in the directions of capsule delivery, medical preparations containing active ingredients, measuring devices, etc. problem, to achieve the effect of good reproducibility, rapid and accurate detection

Active Publication Date: 2006-07-12
TIANJIN HONGRENTANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0029] The Xuefu Zhuyu capsule quality standards disclosed above still have identification items, identification means, and content determination methods that are not perfect. The cost is high, the preparation method of the original capsule dosage form, the dosage is 6 capsules each time, the dosage is large, the absorption in the body is slow, and it is inconvenient to take. It does not meet the standards of three small, three-effect and five-convenience

Method used

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  • Preparation method of 'Xue Fu Zhu Yu' capsule and quality standard thereof
  • Preparation method of 'Xue Fu Zhu Yu' capsule and quality standard thereof
  • Preparation method of 'Xue Fu Zhu Yu' capsule and quality standard thereof

Examples

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Effect test

Embodiment 1

[0239] Example 1 Improved Xuefu Zhuyu Capsule Quality Standard

[0240] 1. Name: Xuefu Zhuyu Capsules

[0241] 2. Prescription:

[0242] Peach kernel (stir-fried) Angelica aurantium husk (stir-fried with bran) Chuanxiong

[0243] Bupleurum safflower Achyranthes bidentata Radix Paeoniae Rubra

[0244] Rehmannia glutinosa Licorice

[0245] 【Properties】This product is a capsule, and the content is a brown powder; the gas is pungent, and the taste is slightly bitter.

[0246] [Preparation method] Extract 11 medicinal herbs such as angelica with water for 1-3 times, use 6-10 times the amount of water, filter for 0.5-1.5 hours each time, collect the filtrate, and concentrate under reduced pressure to a relative density of 1.07-1.35 ( 60-70°C), leave it at room temperature, add ethanol to make the alcohol content 60-80%, stir well, let it stand (5-25h) to precipitate, take the supernatant and concentrate it under reduced pressure to a relative density of 1.30-1.50 (60-70°C) add ...

Embodiment 2

[0281] Take 1.35kg of eleven herbs such as angelica, extract with water twice, each time with 8 times the water consumption, each extraction time is 1h, filter, collect the filtrate, concentrate under reduced pressure to a relative density of 1.16 (60°C), and place it in the cold At room temperature, add ethanol to make the alcohol content 70%, stir well, let it stand for precipitation, take the supernatant and concentrate it under reduced pressure to a relative density of 1.402 (60°C), add 61.5g of starch, and dry it in a drying oven for 9h ( T=70-75° C.) to obtain 378 g of dry matter, add 22.68 g of silicon dioxide, pulverize through a 40-mesh sieve, pack into capsules, and make 1000 grains. (Each gram of capsule is equivalent to 3.375g of crude drug)

Embodiment 3

[0283] Take 1.35 kg of eleven herbs such as angelica, extract with water 3 times, each time with 6 times the water consumption, each extraction time is 0.5h, filter, collect the filtrate, concentrate under reduced pressure to a relative density of 1.08 (60°C), and wait for cooling Leave it at room temperature, add ethanol to make the alcohol content 60%, stir well, let it stand for precipitation, take the supernatant and concentrate it under reduced pressure to a relative density of 1.43 (60°C), add 64.8g of starch, and dry in a drying oven for 9 hours (T=65-70° C.), to obtain 375 g of dry matter, add 25.53 g of silicon dioxide, pulverize through a 24-mesh sieve, pack into capsules, and make 1000 grains. (Each gram of capsule is equivalent to 3.215g of crude drug)

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Abstract

Disclosed is a preparation method of 'Xue Fu Zhu Yu' capsule and quality standard, wherein in the quality standard, identification items for peach kernel, fruit of citron and extractum glycyrrhizae liquidum are arranged. Calculated on peony glycosides (C23H28011), each unit of the capsule should contain no less than 2.20mg. The method of inspection and quality improvement, the optimized process and technological conditions are also disclosed.

Description

technical field [0001] The present invention relates to the technical field of medical preparations (International Patent Classification No. 35 / 79) derived from plants containing reaction products of unknown structure, in particular, a kind of Xuefu Zhuyu made from extracts of Chinese herbal medicines The preparation method of the capsule and its quality standard. Background technique [0002] Xuefu Zhuyu Jiaonang is a classic Chinese patent medicine, the Ministry of Health standard WS 3 -B-0928-91 records the prescription and quality standard: [0003] Peach kernel (stir-fried) Angelica aurantium husk (stir-fried with bran) Chuanxiong [0004] Bupleurum safflower Achyranthes bidentata Radix Paeoniae Rubra [0005] Rehmannia glutinosa Licorice [0006] 【Properties】This product is a capsule, and the content is a brown powder; the gas is pungent, and the taste is slightly bitter. [0007] [Identification] (1) Take this product and observe under a microscope: the stone cel...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K9/48A61P43/00G01N30/90G01N33/15
Inventor 朱晓晶李凤阁马洪波王齐李永仓赵喆
Owner TIANJIN HONGRENTANG PHARM CO LTD
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