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Dexibuprofen suspension composition and preparation method thereof

A suspension and composition technology, applied in the field of dextroibuprofen suspension composition and its preparation, can solve problems such as high viscosity and inaccurate dosage of medicines, and achieve fast absorption and controllable preparation process quality Good stability and easy pouring effect

Inactive Publication Date: 2016-12-07
SHANGHAI YANAN PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the sedimentation volume ratio of the currently marketed oral suspension is close to 1, its viscosity is high, which is not conducive to drug dumping, resulting in inaccurate drug dosage

Method used

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  • Dexibuprofen suspension composition and preparation method thereof
  • Dexibuprofen suspension composition and preparation method thereof
  • Dexibuprofen suspension composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Present embodiment relates to a kind of preparation method of Dexibuprofen suspension composition, it comprises the steps:

[0027] After mixing 2g of low-acyl gellan gum, 5g of pectin, 1g of sodium alginate and 12g of water-soluble chitosan evenly, add 3000g of water in total and stir evenly at 70-90°C to form a clear solution;

[0028] Add 2g of potassium chloride, after dissolving, add 300g of Dexibuprofen, stir evenly, then add 12000g of water, mix well to obtain the Dexibuprofen suspension composition.

Embodiment 2

[0030] Present embodiment relates to a kind of preparation method of Dexibuprofen suspension composition, it comprises the steps:

[0031] After mixing 5g of low-acyl gellan gum, 2g of pectin, 5g of sodium alginate and 3g of water-soluble chitosan evenly, add 1500g of water in total and stir evenly at 70-90°C to form a clear solution;

[0032] Add 10g of calcium lactate, after dissolving, add 100g of Dexibuprofen, stir evenly, then add 13500g of water, mix well to obtain the Dexibuprofen suspension composition.

Embodiment 3

[0034] Present embodiment relates to a kind of preparation method of Dexibuprofen suspension composition, it comprises the steps:

[0035] Mix 3.5g of low-acyl gellan gum, 3.5g of pectin, 3g of sodium alginate and 7.5g of water-soluble chitosan evenly, add 2250g of water in total, and stir evenly at 70-90°C to form a clear solution ;

[0036] Add 3g of potassium chloride and 3g of calcium lactate, after dissolving, add 200g of Dexibuprofen, stir evenly, then add 12750g of water, and mix well to obtain the Dexibuprofen suspension composition.

[0037] Compared with the prior art, the present invention has the following beneficial effects:

[0038] The dextroibuprofen is stably dispersed in the medium in the dispersion unit forming the suspension, has low viscosity, high suspending ability, is not easy to aggregate and settle, and never separates. Compared with common Dexibuprofen preparations, it has the advantages of being able to keep the particle size unchanged in long-ter...

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Abstract

The invention discloses dexibuprofen suspension and a preparation method thereof. The preparation comprises dexibuprofen, low acyl gellan gum, carrageenan, pectin and a colloidality enhancer. The dexibuprofen suspension prepared by adopting the method is a thixotropic liquid, has the characteristics of low viscosity, high suspending property and no layering forever and has the beneficial effect that the particle size of dexibuprofen can remain stable in long-term storage.

Description

technical field [0001] The invention relates to a dexibuprofen suspension composition and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Ibuprofen, a derivative of phenylpropionic acid, is a safe and effective drug among traditional NSAIDs, and it is the first drug recommended in the pain ladder. Non-steroidal anti-inflammatory drugs (NSAIDs) have antipyretic and analgesic effects and are widely used in clinical practice. [0003] Dexibuprofen, the chemical name is (2s)-2-[4-(2-methylpropyl)phenyl]ropionic acid(S)-2-(+)-(4-isobutylphenyl)propyl Acid, which is the S-(+)-isomer of ibuprofen (racemate), a widely used non-steroidal anti-inflammatory drug. [0004] The structural formula is: [0005] [0006] Dexibuprofen and ibuprofen have the same effect and use, but dexibuprofen is obviously superior to ibuprofen in terms of safety and pharmacokinetic properties. [0007] Dexibuprofen was firs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/192A61K47/36A61P29/00
CPCA61K9/10A61K31/192A61K47/36
Inventor 王学亮
Owner SHANGHAI YANAN PHARM
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