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Preparation method of dexibuprofen injection

A technology for preparing dextro-ibuprofen and injection, applied in the field of medicine, can solve the problems of low bioavailability, poor absorption, slow onset and the like, and achieve the effects of increasing solubility, increasing solubility and avoiding degradation

Inactive Publication Date: 2016-01-27
NANJING KEFEI PINGSHENGHUI PHARMA CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Dexibuprofen is similar to other non-steroidal anti-inflammatory drugs (NSAIDS), which has the characteristics of poor absorption, low bioavailability, and slow onset of action

Method used

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  • Preparation method of dexibuprofen injection
  • Preparation method of dexibuprofen injection
  • Preparation method of dexibuprofen injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] prescription:

[0016]

[0017] Preparation process: Dissolve 312g of L-arginine in water for injection, then add 400g of ibuprofen to dissolve, add water for injection to the required amount; adjust the pH value to 7.4 and filter the solution with a 0.22um filter membrane, After fine filtration, it was filled in an ampoule, and sterilized by damp heat at 121°C for 15 minutes to obtain Dexibuprofen Injection.

Embodiment 2

[0019] prescription:

[0020]

[0021] Preparation process: Dissolve 320g of L-arginine in water for injection, then add 400g of ibuprofen to dissolve, add water for injection to the required amount; adjust the pH value to 7.4 and filter the solution with a 0.22um filter membrane, After fine filtration, it was filled in an ampoule, and sterilized by damp heat at 121°C for 15 minutes to obtain Dexibuprofen Injection.

Embodiment 3

[0023] prescription:

[0024]

[0025] Preparation process: Dissolve 340g of L-arginine in water for injection, then add 400g of Dexibuprofen to dissolve, add water for injection to the required amount; adjust the pH value to 7.4, and filter the solution with a 0.22um filter membrane , after fine filtration, fill and seal in ampoules, and sterilize with damp heat at 121°C for 15 minutes to obtain Dexibuprofen Injection.

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Abstract

The invention provides a preparation method of a dexibuprofen injection. The method prepares dexibuprofen and appropriate auxiliary materials into a dexibuprofen injection with stable and controllable quality. The dexibuprofen injection relieves pain and fever of inpatients unable to employ oral administration, also has the advantages of avoidance of first pass effect and gastrointestinal reaction of drugs, quick effect, and good stability, etc.

Description

technical field [0001] The invention relates to a preparation method of Dexibuprofen injection, which belongs to the technical field of medicine. Background technique [0002] Dextroibuprofen is the dextrorotatory form of ibuprofen. This product is white or off-white crystalline powder with a slightly peculiar smell and almost tasteless. The melting point is 49-53°C. Easily soluble in ethanol, acetone, chloroform, ether and aqueous sodium hydroxide solution, almost insoluble in water. [0003] The chemical name of Dexibuprofen is: S-Ibuprofen; (2S)-2-(4-isobutylphenyl)propionic acid, which has the following chemical structure: [0004] [0005] Storage conditions: Keep in a cool and airtight place. [0006] Dexibuprofen is a non-steroidal anti-inflammatory drug (NSAIDs) with good anti-inflammatory, antipyretic and analgesic effects, and is widely used to treat arthritis (especially RA, OA) and pain caused by various inflammations. Ibuprofen was first launched in the U...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/192A61K47/18A61K47/02
Inventor 秦引林殷连珍
Owner NANJING KEFEI PINGSHENGHUI PHARMA CO LTD
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