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Preparation method of dexibuprofen sustained-release agent

A technology of slow-release agent and montmorillonite, which is applied in the field of preparation of Dexibuprofen sustained-release agent, can solve the problems of many times of administration, many types of synthetic products, adverse reactions, etc., and achieve accurate and detailed data and process flow. Short, non-polluting effect on the environment

Active Publication Date: 2017-02-08
SHANXI MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Dextroibuprofen is the dextrorotatory form of ibuprofen, which belongs to aryl propionic acid non-steroidal anti-inflammatory drugs. It mainly inhibits the synthesis of prostaglandins or other inflammatory mediators, and has anti-inflammatory, analgesic and antipyretic effects; The half-life of arylpropionic acid NSAIDs is short, and the dextroibuprofen has adverse reactions to the gastrointestinal tract and central nervous system; the dextroibuprofen tablets and suppositories used for children have poor taste, The disadvantages of many times of administration and large adverse reactions, in order to overcome this disadvantage, it is necessary to prepare Dexibuprofen sustained release
[0003] The preparation method of Dexibuprofen slow-release agent mainly contains skeleton type sustained-control release preparation, film-coated slow-control release preparation, osmotic pump type slow-control release preparation, slow-control release microcapsule, slow-control release microsphere; Some sustained and controlled release technologies, such as gastric retention technology, bioadhesion technology, ion exchange technology, and solid dispersion technology; the raw materials used are divided into natural and synthetic, and natural is pollution-free, with small output and single performance; synthetic Many, large output, but accompanied by side effects; from the biological performance can be divided into degradable and non-degradable; in a word, there are many disadvantages in the preparation of Dexibuprofen sustained release agent, which is still in scientific research

Method used

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Embodiment Construction

[0063] The present invention will be further described below in conjunction with accompanying drawing:

[0064] figure 1 As shown, in order to prepare the state diagram of the montmorillonite mixture, the positions of each part must be correct, the ratio should be proportioned, and the operations should be performed in sequence.

[0065]Quantities of chemicals used in preparation are determined in pre-set ranges in grams, milliliters, centimeters 3 is the unit of measurement.

[0066] The preparation of the montmorillonite mixture is carried out in a three-necked flask, which is completed under the conditions of heating in a water bath, argon protection, magnetic stirring, and water circulation and condensation;

[0067] The water bathtub 1 is rectangular, and there is a three-necked flask 3 on the top of the water bathtub 1, and is fixed by a fixed seat 13; the bottom of the water bathtub 1 is an electric control box 2; Argon tube 16, liquid addition funnel 4, control valv...

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Abstract

The invention relates to a preparation method of a dexibuprofen sustained-release agent, and aims to overcome the medical treatment and preparation defects of dexibuprofen medicine. The preparation method comprises the following steps: taking montmorillonite, hydrochloric acid, absolute ethanol and deionized water as raw materials; modifying the montmorillonite; preparing an aqueous hydrochloric acid solution and montmorillonite mixed liquor; performing ultrasonic dispersion, centrifugal separation, vacuum freeze drying, grinding and sieving to prepare dexibuprofen sustained-release agent powder particles, wherein the particle diameters of the particles are smaller than or equal to 200nm, and the product purity is up to 99.6 percent. The preparation method has the advantages of advanced process, accurate and complete data, short process flow and freeness from environmental pollution, and is an advanced method for preparing the dexibuprofen sustained-release agent; the dexibuprofen sustained-release agent can be applied to clinical medication in the department of pediatrics.

Description

technical field [0001] The invention relates to a preparation method of a dexibuprofen sustained-release agent, belonging to the technical field of preparation and application of pharmaceutical preparations. Background technique [0002] Dextroibuprofen is the dextrorotatory form of ibuprofen, which belongs to aryl propionic acid non-steroidal anti-inflammatory drugs. It mainly inhibits the synthesis of prostaglandins or other inflammatory mediators, and has anti-inflammatory, analgesic and antipyretic effects; The half-life of arylpropionic acid NSAIDs is short, and the dextroibuprofen has adverse reactions to the gastrointestinal tract and central nervous system; the dextroibuprofen tablets and suppositories used for children have poor taste, The disadvantages of many times of administration and large adverse reactions, in order to overcome this disadvantage, it is necessary to prepare a sustained-release formulation of Dexibuprofen. [0003] The preparation method of Dex...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/192A61K47/02A61P29/00
CPCA61K9/0002A61K9/143A61K31/192
Inventor 李婷婷赵乐乐张淑秋王税利代华灵
Owner SHANXI MEDICAL UNIV
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