Preparation method of dexibuprofen amino acid salt

A technology of amino acid salt and amino acid, which is applied in the direction of carboxylate salt preparation, separation/purification of carboxylic acid compounds, medical preparations containing active ingredients, etc., can solve the problems that the preparation method cannot be reproduced, and achieve good reproducibility, The preparation process is simple and the effect of low impurity content

Inactive Publication Date: 2009-11-04
航天中心医院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The preparation methods of the abo

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Weigh 10.5g of dextrobuprofen, dissolve it in 56ml of ethanol to obtain dextrobuprofen ethanol solution; at room temperature and under stirring, gradually add 8.7g of arginine into the dextrobuprofen ethanol solution, Stirring was continued for 1 hour; filtered, washed twice with a little ethanol, and vacuum-dried at 50°C to obtain a white solid, which was Dexibuprofen arginine salt.

Embodiment 2

[0016] Take by weighing Dexibuprofen 10.5g, be dissolved in 95% ethanol 56ml, obtain Dexibuprofen ethanol solution; At room temperature and under stirring, arginine 8.7g is added gradually in Dexibuprofen ethanol solution, Continue to stir for 1 hour after the addition; filter, wash twice with a little ethanol, and dry under vacuum at 50°C to obtain a white solid, which is Dexibuprofen arginine salt.

Embodiment 3

[0018] Weigh 10.5 g of dextrobuprofen, dissolve it in 56 ml of ethanol to obtain a dextrobuprofen ethanol solution; at room temperature and under stirring, gradually add 7.3 g of lysine into the dextrobuprofen ethanol solution, and Then continue to stir for 1 hour; filter, wash twice with a little ethanol, and vacuum-dry at 50°C to obtain a white solid, which is dextroibuprofen lysine salt.

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Abstract

The invention discloses a preparation method of dexibuprofen amino acid salt. The method is characterized by adding amino acid to dexibuprofen ethanol solution while stirring at room temperature, and completing salt forming and crystallization in turn in a container, and the method has the advantages of simple and convenient preparation process, short production period, low impurity level, high yield and good reproducibility. The dexibuprofen amino acid salt can be used for preparing oral solution preparation, also can be used for preparing injection preparation, accelerates absorption rate, enhances bioavailability and enlarges application range.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and relates to a preparation method of Dexibuprofen amino acid salt. Background technique [0002] Ibuprofen (Ibuprofen) is a phenylpropionic acid non-steroidal anti-inflammatory analgesic, which has strong antipyretic, analgesic, anti-inflammatory and anti-rheumatic effects, and its curative effect is similar to that of aspirin and phenylbutazone. Phenol is good, and the gastrointestinal side effects are mild and well tolerated. It is an antipyretic and analgesic widely used at present. The dosage forms of ibuprofen listed both at home and abroad include ordinary tablets, sustained-release tablets, capsules, suspensions, suppositories, creams, etc. [0003] Dexibuprofen is the active enantiomer of ibuprofen and has pharmacological activity. At present, the oral preparations of Dexibuprofen are on the market both at home and abroad. [0004] Dexibuprofen is widely used clinically as a phenylpr...

Claims

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Application Information

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IPC IPC(8): C07C57/30C07C51/41C07C51/43A61K31/192A61P29/00
Inventor 刘会臣韩静王涛王振龙杜玉民刘杏敏
Owner 航天中心医院
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