Dexibuprofen slow-release capsule and production method thereof
A sustained-release capsule and the technology inside the capsule, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, drug delivery, etc., can solve problems such as large side effects, increased burden on patients, and large changes in the concentration of dextroibuprofen
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Embodiment 1
[0031] Dexibuprofen sustained-release capsules are filled with pellets. The pellets are composed of a pellet core and four layers of materials wrapped around the pellet core. The four layers of materials are in order from inside to outside: inner isolation layer, coating layer I, coating layer II and coating layer III, ball core, internal isolation layer, coating layer I, coating layer II and coating layer III are composed as follows: ball core is a pharmaceutical excipient composed of sucrose and starch ; The inner isolation layer is stearic acid; Coating layer I is a coating mixture; Coating layer II contains coating mixture and stearic acid; Coating layer III is a coating mixture; : 1 composition of dextrobuprofen and povidone K30, the weight ratio of the coating mixture in the coating layer I, coating layer II and coating layer III is 85:3:10, and the coating layer II is coated with The weight ratio of coating liquid and stearic acid is 2: 1, and the weight of dextrobuprof...
Embodiment 2
[0034] Dexibuprofen sustained-release capsules are filled with pellets. The pellets are composed of a pellet core and four layers of materials wrapped around the pellet core. The four layers of materials are in order from inside to outside: inner isolation layer, coating layer I, coating layer II and coating layer III, ball core, internal isolation layer, coating layer I, coating layer II and coating layer III are composed as follows: ball core is a pharmaceutical excipient composed of sucrose and starch ; The inner isolation layer is stearic acid; Coating layer I is a coating mixture; Coating layer II contains coating mixture and stearic acid; Coating layer III is a coating mixture; The coating mixture is 30% by weight Composition of dextrobuprofen and povidone K30 in 1:1, the weight ratio of the coating mixture in the above coating layer I, coating layer II and coating layer III is 80:4:10, and the coating layer II is coated with The weight ratio of coating solution and stea...
Embodiment 3
[0037]Dexibuprofen sustained-release capsules are filled with pellets. The pellets are composed of a pellet core and four layers of materials wrapped around the pellet core. The four layers of materials are in order from inside to outside: inner isolation layer, coating layer I, coating layer II and coating layer III, ball core, internal isolation layer, coating layer I, coating layer II and coating layer III are composed as follows: ball core is a pharmaceutical excipient composed of sucrose and starch ; The inner isolation layer is stearic acid; Coating layer I is a coating mixture; Coating layer II contains coating mixture and stearic acid; Coating layer III is a coating mixture; The coating mixture is 35% by weight Composition of dextrobuprofen and povidone K30 in 1:1, the weight ratio of the coating mixture in the coating layer I, coating layer II and coating layer III is 88:6:10, and the coating layer II is coated with The weight ratio of coating solution and stearic aci...
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