Recipe of breviscapine drop pills and preparing method

A technology of scutellarin and dripping pills, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, pill delivery, etc., can solve the problems that there are no dripping pill preparations, and achieve the reduction of the number of medications for patients, easy solvents, and cleaning full effect

Inactive Publication Date: 2003-04-09
HUAZHONG UNIV OF SCI & TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report about its drop pill preparation

Method used

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Embodiment Construction

[0021] The preparation method of breviscapine dripping pills is as follows:

[0022] According to the percentages of the components listed in Table 1, weigh Polyethylene Glycol-6000 and heat it to melt, then weigh stearic acid and Poloxamer 188 and add it to the melted Polyethylene Glycol-6000, after it is completely melted , add breviscapine powder, stir well, transfer to the dripping tube under the condition of heat preservation 85 ℃, heat the temperature 85 ℃, drop the molten mixture into the liquid paraffin in the ice-water bath, condense and solidify into pellets, and use cyclohexane Wash off the liquid paraffin to obtain scutellarin dripping pills. The liquid paraffin can also be washed away with petroleum ether to obtain scutellarin dripping pills.

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PUM

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Abstract

The breviscaping drop pill prepared via a solid dispersing process has the recipe comprising breviscapine 20-30 wt%, polyglycol-6000 40-60 wt%, stearic acid 10-30 wt% and poloxamer-188 5-25 wt%. The preparation process includes heating to smelt polyglycol-6000, adding stearic acid and poloxamer-188, adding breviscaping powder while stirring, transferring to dropping pipe while maintaining the temperature, dropping the molten into liquid paraffin in ice water bath to solidify into pill and washing out the liquid paraffin. The present invention has high biological utilization of medicine, delays the medicine release time and reduces medicine taking times.

Description

technical field [0001] The invention relates to a formula of a traditional Chinese medicine form and a preparation method thereof, in particular to a formula of scutellarin dripping pills and a preparation method thereof. Background technique [0002] Erigeron breviscapus (Vant.) Hand-Mazz is the dry whole herb of Compositae plant Erigeron breviscapus (Vant.) Hand-Mazz, also known as Erigeron breviscapus and East chrysanthemum. According to the records of Materia Medica, Erigeron breviscapus is cold in nature, slightly bitter, sweet and warm, and has the effects of dispelling cold and relieving the exterior, expelling wind and dampness, promoting blood circulation and removing stasis, dredging meridian and activating collaterals, reducing inflammation and relieving pain. At present, Breviscapus is mainly used clinically for the treatment of ischemic cardiovascular and cerebrovascular diseases, especially for cerebral infarction, which has a very significant curative effect. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20
Inventor 杨祥良刘宏徐辉碧冯云典周林珠刘琼杨亚江
Owner HUAZHONG UNIV OF SCI & TECH
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