Use of Dexibuprofen and Levocetirizine Sustained-release Double-Layer Tablets in the Treatment of Airway Inflammation
A levocetirizine and airway inflammation technology, applied in the field of pharmacy, can solve the problems of restricting the application of new compositions, no research reports on compound preparations on the market, and the curative effect can not fully meet the clinical needs, etc., to reduce leukocyte exudation and aggregation, relieve alveolar collapse and atelectasis, and inhibit nasal mucosal inflammation
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0073] Embodiment 1: Preparation of Dexibuprofen and Levocetirizine Sustained-release Double-Layer Tablets
[0074] Prescription (1000 tablets)
[0075] Immediate Release Layer Prescription
45g
Levocetirizine dihydrochloride
2.5g
25g
25g
compressible starch
50g
Crospovidone
12g
8% povidone K30 in 95% ethanol solution
Appropriate amount
silica
1g
1g
Extended Release Layer Prescription
Dexibuprofen (or its pharmaceutically acceptable salt)
180g
Hydroxypropyl Methyl Cellulose K4m
15g
30g
compressible starch
18g
Food coloring (such as sunset yellow aluminum tint, etc.)
Appropriate amount
Tween 80
Appropriate amount
8% polyvinylpyrrolidone 80% ethanol solution
Appropriate a...
Embodiment 2
[0079] Example 2: Effect of Dexibuprofen and Levocetirizine Sustained-release Double-Layer Tablets on Paw Swelling of Rats Induced by Carrageenan
[0080] 1) Preparation of paw swelling model in rats induced by carrageenan
[0081] Rats were randomly divided into 9 groups according to body weight, 8 rats in each group, respectively 0.5% sodium carboxymethylcellulose solution group (negative control), and the other 8 groups were drug treatment groups. After intragastric administration for 1 hour, the volume of the left hind paw of the rats was measured by the volumetric method (UGO BASILE Company, Italy, 7140 volume measuring instrument). Then 0.1ml of 1% carrageenan was subcutaneously injected into the left hind paw, and then the volume of the left hind paw was measured 1, 2, 3, and 4 hours after the injection. Calculate the swelling value (the difference between the volume after inflammation and the volume before inflammation), and compare the difference of swelling value be...
Embodiment 3
[0086] Example 3: Effect of Dexibuprofen and Levocetirizine Sustained-release Double-Layer Tablets on the Swelling Degree of Otitis in Mice
[0087] 1) Preparation of mouse auricular xylene-induced inflammation model
[0088] The mice were randomly divided into 9 groups, 10 mice in each group. They were 0.5% sodium carboxymethylcellulose solution group (negative control), and the other 8 groups were drug treatment groups. 30 minutes after intragastric administration, all mice were coated with appropriate amount of xylene (about 0.1ml) with cotton swabs on the front and back sides of the right ear of the tested mice to cause inflammation. After 4 hours of inflammation, the mice were sacrificed by devertebral dislocation, and the two ears were cut off along the baseline of the auricle. Use a 7mm diameter punch to punch the left and right ear pieces in the same part of the two ears respectively. Weigh and record the weights of the left and right slices with a micro electronic ...
PUM
Property | Measurement | Unit |
---|---|---|
Hardness | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com