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A grinding method of Dexibuprofen and the preparation method of its suspension

A grinding method and technology of grinding materials, which are applied in liquid transportation, emulsion transportation, antipyretic drugs, etc., to achieve good application prospects and industrial production potential effects

Active Publication Date: 2017-12-19
湖北唯森制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] As mentioned above, the various methods of preparing ibuprofen suspension are disclosed in the prior art, but these methods all do not put the emphasis on the grinding treatment method of ibuprofen, and still have the same effect on the ibuprofen suspension. Novel preparation method exists the demand and the necessity of further research, and this is exactly where the driving force and foundation of the present invention can be accomplished

Method used

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  • A grinding method of Dexibuprofen and the preparation method of its suspension
  • A grinding method of Dexibuprofen and the preparation method of its suspension
  • A grinding method of Dexibuprofen and the preparation method of its suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: the investigation of organic solvent kind

[0046] S1: adding Dexibuprofen to the mixed solvent to obtain a mixture of Dexibuprofen, specifically:

[0047] 1.5 parts by mass of Dexibuprofen are added to a mixed solvent of 3 parts by mass of organic solvent (see Table 1 below for specific composition) and 1 part by mass of water, and fully stirred to obtain a mixture of Dexibuprofen;

[0048] S2: prepare acidic sol, specifically:

[0049] In parts by mass, 3 parts of agar, 1 part of sodium citrate, 1.1 parts of sodium benzoate, 12 parts of sucrose and 0.25 parts of mannitol were added to 100 parts of double distilled water, and kept stirring until the agar swelled completely, and the mixture was adjusted. The pH value is 5.0, and an acidic sol is obtained;

[0050] S3: After mixing the dextrobuprofen mixture obtained in step S1 with the acid sol obtained in step S2, grind to obtain a dextrobuprofen grind, specifically:

[0051] S3-1: Weighing 100 parts b...

Embodiment 2

[0060] Embodiment 2: the investigation of organic solvent composition

[0061] S1: adding Dexibuprofen to the mixed solvent to obtain a mixture of Dexibuprofen, specifically:

[0062] 1.5 parts by mass of dextroibuprofen are added to 3 parts by mass of organic solvent (for the mixture of ethylene glycol and glycerin, the volume ratio is shown in the following table 2) and in the mixed solvent of 1 part by mass of water, fully stirred to obtain dextro ibuprofen ibuprofen mixture;

[0063] Other steps S2, S3 and the preparation of the subsequent suspension are the same as in Example 1.

[0064] The obtained Dexibuprofen suspension was placed for a period of time, and the changes in its appearance and various indicators were observed to investigate the influence of different organic solvent compositions on the stability of the product. The results are shown in Table 2 below.

[0065] Table 2

[0066]

[0067] Among them, "Example 2" indicated by "*" is actually Example 1. ...

Embodiment 3

[0069] Embodiment 3: the investigation of organic solvent and water consumption ratio

[0070] S1: adding Dexibuprofen to the mixed solvent to obtain a mixture of Dexibuprofen, specifically:

[0071] 1.5 parts by mass of Dexibuprofen are added to the mixed solvent of 3 parts by mass of organic solvent (a mixture of ethylene glycol and glycerol in a volume ratio of 4:1) and water (the mass ratio of organic solvent to water is shown in Table 3 below) In, fully stir, thus obtain the Dexibuprofen mixture;

[0072] Other steps S2, S3 and the preparation of the subsequent suspension are the same as in Example 1.

[0073] The obtained Dexibuprofen suspension was placed for a period of time, and its appearance and changes in various indicators were observed to investigate the influence of different organic solvent compositions on the stability of the product. The results are shown in Table 3 below.

[0074] table 3

[0075]

[0076] Among them, "Example 3" indicated by "*" is ac...

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Abstract

The invention relates to a grinding method of dexibuprofen, a preparation method of dexibuprofen suspension, and the dexibuprofen suspension obtained through the preparation method. The grinding method comprises the following steps: S1, adding dexibuprofen into a mixed solvent, and carrying out sufficient stirring, thus obtaining the dexibuprofen mixture; S2, preparing an acid sol; and S3, mixing the dexibuprofen mixture obtained in S1 with the acid sol obtained in S2, and carrying out grinding, thus the dexibuprofen grinded matter is obtained, and the grinding treatment is completed. According to the grinding method, through the comprehensive selection and synergy of a plurality of specific technical features, the dexibuprofen suspension with excellent performance is finally obtained. When the technical features are changed, the performance of the finally obtained suspension can be reduced, which means that the most stable dexibuprofen suspension can be obtained by adopting the grinding method, and therefore, grinding method and the preparation method have good application prospect and industrial production potential in the field of medicines.

Description

technical field [0001] The present invention relates to a kind of grinding method of pharmaceutical compound and its suspension preparation method, more particularly relate to a kind of grinding method of Dexibuprofen and its suspension (i.e. Dexibuprofen suspension) The preparation method belongs to the technical field of pharmaceutical preparations. Background technique [0002] Ibuprofen is a commonly used non-steroidal anti-inflammatory drug, which has good anti-inflammatory, analgesic, antipyretic and other drug activities, and has less adverse reactions. It is often used clinically for the treatment of fever and mild to moderate pain. . [0003] Studies have found that the pharmacological activity of ibuprofen mainly comes from its dextro-form compound (i.e., ibuprofen). Compared with ibuprofen, dexibuprofen has higher curative effect, and a smaller dose is It can achieve therapeutic effect, and is also superior to ibuprofen in terms of safety and pharmacokinetic pro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K31/192A61K47/10A61P29/00
CPCA61K9/10A61K31/192A61K47/10
Inventor 刘铁军
Owner 湖北唯森制药有限公司
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