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Dexibuprofen particles and preparation method thereof

A technology of dextro-ibuprofen and granules, applied in the field of dex-ibuprofen granules and its preparation, can solve problems such as poor dissolution performance, and achieve the effects of improving human body bioavailability and good economic and social benefits

Active Publication Date: 2012-03-28
NANJING ZENKOM PHARMA
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0055] The purpose of the present invention is to provide a kind of dextrobuprofen granule, has adopted self-emulsifying drug release system, solves the characteristic that the dissolution property of existing dextrobuprofen preparation is not good, thereby promotes the absorption of human body to dextrobuprofen and use

Method used

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  • Dexibuprofen particles and preparation method thereof
  • Dexibuprofen particles and preparation method thereof
  • Dexibuprofen particles and preparation method thereof

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Embodiment

[0074] prescription:

[0075]

[0076]Preparation process: (1) add isopropyl myristate, polyoxyethylene hydrogenated castor oil and diethylene glycol ethyl ether according to the prescription ratio, and mix evenly to obtain from the emulsified oil base; (2) weigh the right amount of the prescription amount Rotate ibuprofen, add in self-emulsifying oil matrix, ultrasonic to transparent solution, obtain Dexibuprofen self-emulsion, ultrasonic time is 20~30min; Dextrin and poloxamer are used as carriers, placed in a wet mixing granulator, mixed for 600s, added with ethanol to prepare soft materials, granulated with a 24-mesh sieve, dried at 45-55°C, granulated with a 14-mesh sieve, mixed evenly, and divided into granules. Just install it.

[0077] Dissolution of Dexibuprofen Self-emulsifying Granules

[0078] The dissolution test was carried out on the prepared Dexibuprofen granules and commercially available capsules and tablets.

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Abstract

The invention discloses dexibuprofen particles and a preparation method thereof. According to the invention, appropriate auxiliary materials are combined with dexibuprofen, such that dexibuprofen is subject to self-emulsification in gastrointestinal tracts, and is maintained an emulsion. Compared with common dexibuprofen preparations, the dexibuprofen particles provided by the invention has advantages of good dissolution rate, high absorption speed, good controllability of preparation technological quality, good stability, and the like. The invention provides a dexibuprofen preparation with higher security, better curative effect, simpler preparation technology and good stability.

Description

technical field [0001] The invention belongs to the field of pharmaceutical manufacturing, and relates to a new dosage form of ibuprofen, in particular to a granule of ibuprofen and a preparation method thereof. Background technique [0002] Dexibuprofen is the S-(+)-isomer of the widely used non-steroidal anti-inflammatory drug ibuprofen (racemate), which was launched in Austria in 1994 for the treatment of rheumatoid arthritis Inflammation, a racemic compound that is widely used clinically, its anti-inflammatory effect is produced by the S-isomer inhibiting the synthesis of prostaglandins. It has been clarified that the R-isomer is converted into its S-isomer through a coenzyme A thioester intermediate in vivo, and the formation of R-ibuprofen coenzyme A competitively inhibits many reactions that depend on coenzyme A, Thereby interfering with liver cell intermediary metabolism and mitochondrial function. Therefore, the advantages of using pure S-ibuprofen are mainly to r...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/192A61K47/40A61P29/00
Inventor 陆荣政徐卓业文意芬
Owner NANJING ZENKOM PHARMA
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