The invention relates to the technology of pharmaceutical preparation. The invention provides an ibuprofen fat emulsion injection which comprises ibuprofen, injection oil, refined lecithin, glycerol, a stabilizing agent, a pH regulator and injection water. Through animal experiments, the pain easing effect of the ibuprofen fat emulsion injection is 1.59-4.31 times that of the commercially available ibuprofen injection, the antipyretic and anti-inflammatory effects can also be obviously improved, and the ibuprofen fat emulsion injection has certain long-acting effect. Proved by long-time stability experiments, the quality of the ibuprofen fat emulsion injection at normal temperature has no obvious change within two years. The invention provides the ibuprofen fat emulsion injection which can be intravenous, stable, safe, and high-efficiency.