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Ibuprofen compound and pharmaceutical composition thereof

A compound and composition technology, applied in the field of medicine, can solve the problems of increased content of ibuprofen-related substances and poor stability of ibuprofen, and achieve the effects of less impurity content, high safety performance, and good storage stability

Inactive Publication Date: 2013-07-17
北京康瑞达彤科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The stability of ibuprofen in the above-mentioned patents and other prior art is relatively poor, and the content of related substances in ibuprofen rises rapidly after long-term storage. In order to obtain a kind of ibuprofen with better stability, it is proposed this invention

Method used

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  • Ibuprofen compound and pharmaceutical composition thereof
  • Ibuprofen compound and pharmaceutical composition thereof
  • Ibuprofen compound and pharmaceutical composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Preparation of ibuprofen compound:

[0043] Dissolve 50 g of the ibuprofen crude drug in the acetone solution at 60°C to make a saturated solution, slowly add ethanol at 60°C, the volume consumption of ethanol is 1 / 4 of the volume of acetone, keep stirring for 30 minutes, and dissolve the solution at 8m / The speed of s flows through a DC magnetic field of 0.5T, and the direction of the magnetic field is perpendicular to the flow direction of the solution. Activated carbon is added to the treated solution for decolorization, stirred and adsorbed for 30 minutes, filtered for decarbonization and sterilized, and the amount of activated carbon added is 0.3% of the total volume of the liquid medicine. %g / ml to obtain a clear solution, add water dropwise to the clear solution, the volume ratio of the water to acetone is 15:1, cool down to 5°C, filter to obtain a filter cake, wash the filter cake, and then dry under reduced pressure 4h, that is, white microcrystalline powder. ...

Embodiment 2

[0046] Preparation of ibuprofen compound:

[0047] Dissolve 50 g of ibuprofen crude drug in the acetone solution at 50 DEG C to make a saturated solution, slowly add ethanol at 50 DEG C, the volume consumption of ethanol is 1 / 6 of the volume of acetone, keep stirring for 60 minutes, and dissolve the solution at 15m / The speed of s flows through a 0.5T DC magnetic field, and the direction of the magnetic field is perpendicular to the flow direction of the solution. Add activated carbon to the treated solution for decolorization, stir and adsorb for 30 minutes, filter for decarbonization and sterilization, and the amount of activated carbon added is 0.2% of the total volume of the liquid. %g / ml to obtain a clear solution, add water dropwise to the clear solution, the volume ratio of the water to acetone is 8:1, cool down to 0°C, filter to obtain a filter cake, wash the filter cake, and then dry under reduced pressure 2h, that is, white microcrystalline powder. Yield 74.9%, HPLC...

Embodiment 3

[0050] Preparation of Ibuprofen Sterile Powder Injection

[0051] Weigh 400g of ibuprofen and 320g of arginine prepared in Example 1 under aseptic conditions, place them in a solid powder mixer and mix them evenly, and the raw materials obtained are transferred to a sterile preparation workshop for precise metering and subpackaging. Each bottle contains Profen 0.4g, stoppered and capped, the finished product is packaged for storage and sent for inspection.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to an ibuprofen compound. The structure formula of the ibuprofen compound is shown in the specification. An X-ray powder diffraction spectrum of the Ibuprofen compound measured by a Cu-K alpha ray is shown in figure 1. A preparation method of the ibuprofen compound and a pharmaceutical composition containing the ibuprofen compound are also provided by the invention. The ibuprofen pharmaceutical composition is ibuprofen injection and Ibuprofen sterile powder injection. Compared with the prior art, the ibuprofen compound and the pharmaceutical composition thereof provided by the invention have better storage stability; and the medication safety of a sufferer is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an ibuprofen compound, a preparation method of the ibuprofen compound and a pharmaceutical composition containing the ibuprofen compound. Background technique [0002] Ibuprofen, English name Ibuprofen, also known as ibuprofen, is a non-steroidal anti-inflammatory analgesic. Its anti-inflammatory, analgesic, and antipyretic effects are good, and its adverse reactions are small. At present, it has been widely used in the world and has become one of the best-selling over-the-counter drugs in the world. It is listed as the three pillar products of antipyretic and analgesic drugs together with aspirin and paracetamol. In our country, it is mainly used in pain relief and anti-rheumatism, but not too much in cold and fever reduction, which is far lower than that of paracetamol and aspirin. There are as many as dozens of pharmaceutical companies in my country that hold t...

Claims

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Application Information

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IPC IPC(8): C07C57/30C07C51/43A61K31/192A61K47/18A61P29/00
Inventor 罗军徐丹周平
Owner 北京康瑞达彤科技有限公司
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