Ibuprofen injection composite and preparation method thereof

Abstract

The invention discloses an ibuprofen injection composite which can obviously improve the quality stability of products and meet the clinical compatibility demand and a preparation method thereof to overcome the defect of the traditional ibuprofen injection. The injection is prepared by mixing ibuprofen and cosolvent according to a molar ratio of 1: 1.001-2, and the pH value of the injection is 7.5-9.0. The ibuprofen injection prepared through the method has obviously improved tolerance capability to high temperature and strong light and better stability and no irritant to vessels, and can effectively meet the requirement of the clinical intravenous drip. Moreover, the preparation method of the invention has the advantages of simple process and good stability of the prepared product.

Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an ibuprofen injection and a preparation method thereof. Background technique

[0002] Ibuprofen is a classic antipyretic and analgesic drug, which can inhibit the synthesis of prostaglandins and has analgesic, antipyretic and anti-inflammatory effects. Due to its remarkable curative effect and few adverse reactions, it was widely used in the world after it went on the market, and the market continued to expand. In the late 1980s, many countries in Europe and the United States turned it into an over-the-counter drug, which accelerated its sales growth and has now become the world's best-selling OTC. One of the drugs. Domestic existing ibuprofen tablets, ibuprofen dispersible tablets, ibuprofen orally disintegrating tablets, ibuprofen capsules, ibuprofen syrup, ibuprofen chewable tablets ibuprofen soft capsules, ibuprofen sustained-release capsules , Ibupro...

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