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Injection containing burufen

An injection and organic solvent technology, which is applied in the field of medicine and its preparation, can solve the problem that ibuprofen does not have an injection dosage form, etc., and achieves the effects of low bioavailability, solving the problems of product solubility and administration route, and slow absorption

Inactive Publication Date: 2007-11-14
汪洪湖
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is exactly to solve the deficiency that existing ibuprofen does not have injection form, provides a kind of injection containing ibuprofen and preparation method, and this preparation solves the problem of product solubility and route of administration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Prescription: Ibuprofen 200g

[0026] Arginine 169g

[0027] Mannitol 150g

[0028] Ethanol 500ML

[0029] Water 4500ML

[0030] Hydrochloric acid amount

[0031] Total volume 5000ML

[0032] Process: dissolving, mixing, decolorizing, filtering, subpackaging and freeze-drying the above raw and auxiliary materials.

Embodiment 2

[0034] Prescription: Ibuprofen 200g

[0035] Lysine 142g

[0036] Mannitol 200g

[0037] Ethanol 100ML

[0038] Water 9900ML

[0039] Hydrochloric acid amount

[0040] Total volume 10000ML

[0041] Process: dissolving, mixing, decolorizing, filtering, subpackaging, and freeze-drying the above raw and auxiliary materials

Embodiment 3

[0043] Prescription: Ibuprofen 200g

[0044] DL-Lysine 142g

[0045] Mannitol 200g

[0046] Ethanol 500ML

[0047] Water 5500ML

[0048] Hydrochloric acid amount

[0049] Total volume 6000ML

[0050] Process: dissolving, mixing, decolorizing, filtering, subpackaging and freeze-drying the above raw and auxiliary materials.

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Abstract

The present invention provides an injection preparation containing ibuprofen and its preparation method. Said invention provides the concrete steps of its preparation method. Said ibuprofen injection preparation has high solubility and bioavailability, and its product quality is stable.

Description

Technical field: [0001] The invention relates to a medicine and a preparation method thereof, in particular to ibuprofen for injection used for treating pain and fever caused by various causes and a preparation method thereof. Background technique [0002] Ibuprofen, namely 2-(4-isobutylphenyl)propionic acid, is a non-steroidal anti-inflammatory drug (NSAIDs) and is the first ibuprofen drug used clinically and is still widely used in the world. It is recognized as one of the safest drugs among NSAIDs. Pharmacological action shows its anti-inflammatory, analgesic and antipyretic effects. Clinically used for various acute and chronic arthritis, soft tissue rheumatism, tenosynovitis, sports injuries and headaches, myalgia, dysmenorrhea, pain after tooth extraction, and cancer pain. The drug is recommended as the first step drug in the analgesic drug ladder, which is recorded in domestic and foreign pharmacopoeias and is one of the basic drugs in my country. Due to some disadv...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K9/08A61K31/198A61K47/26A61K47/10A61P29/00
Inventor 汪洪湖
Owner 汪洪湖
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