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Ibuprofen injection and preparation method thereof

A technology for injection and water for injection, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2011-08-24
付正香
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But most of these drugs are now taken orally

Method used

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  • Ibuprofen injection and preparation method thereof
  • Ibuprofen injection and preparation method thereof
  • Ibuprofen injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Arginine is used as a solubilizer, and the molar ratio of arginine to ibuprofen in the prescription is 0.92:1.

[0052] Prescription: Ibuprofen 40g

[0053] Arginine 31.2g

[0054] Add water for injection to 4000ml

[0055] A total of 1000 pieces were made

[0056] Preparation method: Weigh the prescribed amount of arginine, add 3200ml of water for injection, and stir to dissolve completely. Then add the prescribed amount of ibuprofen, add gradually in portions, and stir while adding. Stirring was continued for 20 minutes after addition to fully dissolve. The sodium hydroxide solution adjusts the pH value of the medicinal solution to 7.2-8.2. Use 0.15% (w / v) activated carbon for needles, adsorb at 50°C for 15 minutes, decarbonize and filter; add water for injection to 4000ml. Continue to filter with a 0.22 μm microporous membrane, and carry out semi-finished product inspection on the obtained clear filtrate. Fill the qualified semi-finished liquid medic...

Embodiment 2

[0057] Example 2 Arginine is a solubilizer, and the molar ratio of it to ibuprofen in the prescription is 0.87:1.

[0058] Ibuprofen 40g

[0059] Arginine 29.5g

[0060] Add water for injection to 4000ml

[0061]

[0062] A total of 1000 pieces were made

[0063] Preparation method: Weigh the prescribed amount of arginine, add 3200ml of water for injection, and stir to dissolve completely. Then add the prescribed amount of ibuprofen, add gradually in portions, and stir while adding. Stirring was continued for 20 minutes after addition to fully dissolve. The sodium hydroxide solution adjusts the pH value of the medicinal solution to 7.2-8.2. Use 0.15% (w / v) activated carbon for needles, adsorb at 50°C for 15 minutes, decarbonize and filter; add water for injection to 4000ml. Continue to filter with a 0.22 μm microporous membrane, and carry out semi-finished product inspection on the obtained clear filtrate. Fill the qualified semi-...

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Abstract

The invention relates to ibuprofen injection and a preparation method thereof. The ibuprofen injection is characterized in that: amino acid in a certain ratio is adopted as a cosolvent to regulate the pH range of the ibuprofen injection, and the prepared injection has the advantages of high dissolubility, high stability and quick response and is suitable for patients who are not suitable for oral administration.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to ibuprofen injection and a preparation method thereof. Background technique [0002] Ibuprofen is a phenylpropionic acid non-steroidal anti-inflammatory analgesic, which has strong anti-inflammatory, anti-rheumatic, antipyretic and analgesic effects. Its curative effect is clear, with mild gastrointestinal side effects and good tolerance , is currently widely used antipyretic analgesics. Prostaglandins are substances related to heat, pain and inflammation in the human body. Ibuprofen inhibits the synthesis of prostaglandins in the human body, thereby exerting antipyretic, analgesic and anti-inflammatory effects. At present, the ibuprofen dosage forms of domestic clinical use include oral solid preparations such as tablets, capsules, granules, and suspensions, and external dosage forms such as ointments and gels. [0003] Oral and external dosage forms of ibuprofen are widely used ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/192A61K47/24A61P29/00
Inventor 付正香
Owner 付正香
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