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Ibuprofen injection and preparation method thereof

A technology for injection and water for injection, applied in pharmaceutical formulations, drug delivery, inorganic non-active ingredients, etc., can solve the problems of unstable protection measures, hidden dangers of patients, difficult growth, etc., to reduce the risk of clinical medication, facilitate doctors and patients, The effect of high safety

Inactive Publication Date: 2012-08-29
罗军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With reference to the preparations listed in the United States, if arginine is used as a cosolvent, it is difficult to suppress the growth of related substances due to its instability and no corresponding protective measures. Although this new dosage form brings convenience to the clinic, its There is a certain risk of medication, which leaves hidden dangers for patients

Method used

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  • Ibuprofen injection and preparation method thereof
  • Ibuprofen injection and preparation method thereof
  • Ibuprofen injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Mix and dissolve 45g of sodium carbonate for injection and 800ml of water for injection in the liquid mixing tank; add 100g of ibuprofen to the above solution at 50°C-60°C, stir and dissolve; add water for injection to 1000ml; then , then add activated carbon for needle adsorption for 15 minutes, decarbonize, measure the content change of the filtered liquid medicine, and test the intermediate product; after the intermediate product passes the test, fine filter, potting, and autoclave at 121°C for 15 minutes to obtain the product.

Embodiment 2-7

[0033] Except that 45g injection grade sodium carbonate is replaced by 35g, 40g, 50g, 55g, 30g, 42g injection grade sodium carbonate respectively, all the other steps are identical with embodiment 1.

Embodiment 8

[0035] Mix 45g of sodium citrate and 800ml of water for injection in the liquid mixing tank, stir and dissolve; at 50°C-60°C, add 100g of ibuprofen to the above solution, stir and dissolve; add water for injection to 1000ml; then , then add activated carbon for needle adsorption for 15 minutes, decarbonize, measure the content change of the filtered liquid medicine, and test the intermediate product; after the intermediate product passes the test, fine filter, potting, and autoclave at 121°C for 15 minutes to obtain the product.

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Abstract

The invention relates to an ibuprofen injection, which comprises ibuprofen and one or a plurality of alkaline cosolvents pharmaceutically acceptable selected from anhydrides or hydrates of sodium carbonate, sodium bicarbonate,sodium citrate, sodium citrate, sodium phosphate, disodium dihydrogen pyrophosphate, sodium tartrate and sodium acetate. The invention also relates to a preparation method of the ibuprofen injection.

Description

technical field [0001] The invention relates to an ibuprofen injection and a preparation method thereof. Background technique [0002] Ibuprofen (Ibuprofen), also known as ibuprofen, is a non-steroidal anti-inflammatory and analgesic drug. Its anti-inflammatory, analgesic and antipyretic effects are good, and its adverse reactions are relatively small. It has been widely used in the world and has become one of the best-selling over-the-counter drugs in the world. It is listed as the three pillar products of antipyretic and analgesic drugs together with aspirin and paracetamol. Since ibuprofen has both anti-rheumatic and antipyretic and analgesic effects, Moreover, the toxicity is low, and it is superior to aspirin and paracetamol in terms of curative effect and side effects, so the market expands rapidly. [0003] At present, common preparations such as ibuprofen tablets, capsules, dispersible tablets, and oral suspensions, like other non-steroidal anti-inflammatory drugs, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/192A61K47/02A61K47/14A61P29/00
Inventor 张颖
Owner 罗军
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