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Dexibuprofen sustained-release dropping pill and preparation method thereof

A technology of sustained-release dripping pills and matrix, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of decreased bioavailability, increased drug-related substances, and out-of-control drug release time And other issues

Inactive Publication Date: 2008-09-24
北京博智绿洲医药科技有限公司
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

The analysis may be affected by factors such as the characteristics of the drug itself, the preparation method, and the external environment, which may cause variation in the structure of Dexibuprofen itself and the crystal form of the substance after the drop pill is formed, thereby increasing the number of related substances in the drug and making the release of the drug more difficult. The time is out of control, and the bioavailability decreases, so, to some extent, it offsets the unique advantages of dripping pills

Method used

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  • Dexibuprofen sustained-release dropping pill and preparation method thereof

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Embodiment Construction

[0033] First group:

[0034] Based on the total weight of 100g, weigh the matrix PEG4000 40%, PEG6000 10%, PEG10000 10%, stearic acid 11%, glyceryl monostearate 17%, stabilizer vitamin E 2%, raw material Dexibuprofen 10% %; Place the matrix in a heating container and heat it and stir it to melt, add the corresponding proportion of ibuprofen, stir well, then add the stabilizer vitamin E and stir evenly, under the condition of heat preservation, melt or mix Drop the medicinal liquid into the condensation column filled with simethicone oil, in which the temperature when heating and melting is 55°C, the temperature of the upper part of the condensate is 20°C, and the temperature of the bottom is -4°C; take it out after forming.

[0035] The obtained product has a cumulative release percentage of 35-55% in 2 hours, a cumulative release percentage of 62-82% in 6 hours, and a cumulative release percentage of 75-95% in 10 hours. There is no obvious change in the assessment of related ...

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Abstract

The invention discloses a pharmaceutical preparation used for resisting inflammation, alleviating pain and eliminating fever, and particularly relates to a prepared sustained-release oral formulation adopting dexibuprofen as the ingredient. The pharmaceutical preparation aims to supplement the deficiency of the prior art and provide a sustained-release dexibuprofen dropping pill. The sustained-release dexibuprofen dropping pill overcomes the defects in the prior art effectively, guarantees no occurrence of an obvious quality change for the drug during the effective storage period and has the advantages of controllable release time, full release and high bioavailability simultaneously.

Description

technical field [0001] The invention relates to a pharmaceutical preparation for anti-inflammation, analgesia and antipyretic, in particular to an oral sustained-release pharmaceutical preparation prepared from Dexibuprofen as a raw material. Background technique [0002] Dexibuprofen is a non-steroidal anti-inflammatory drug, which mainly inhibits the synthesis of cyclooxygenase and prostaglandins to achieve anti-inflammatory and analgesic effects, and has an antipyretic effect through the hypothalamic thermoregulation center. Great promotion and application value. At present, it is mostly used clinically for 1. Relief of acute attack or persistent joint swelling and pain symptoms of various chronic arthritis such as rheumatoid arthritis, osteoarthritis, spondyloarthropathy, gouty arthritis, rheumatoid arthritis, etc. 2. Treatment of non-articular soft tissue rheumatic pain, such as shoulder pain, tenosynovitis, bursitis, myalgia and post-exercise traumatic pain; 3. Acute ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/192A61K47/34A61P29/00A61K47/10
Inventor 彭晓云曲韵智任鲁华
Owner 北京博智绿洲医药科技有限公司
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