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Dexibuprofen microemulsion gel and preparation method thereof

A technology of microemulsion gel and surfactant, which is applied in the field of medicine, can solve the problems of poor comfort of ibuprofen and easy outflow from the cavity, and achieve long residence time, which is conducive to absorption and drug absorption. absorption effect

Active Publication Date: 2015-12-23
山东仁瑞生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the disadvantages of poor water solubility of dexibuprofen and poor medication comfort of dexibuprofen suppository, and easy outflow from cavity.

Method used

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  • Dexibuprofen microemulsion gel and preparation method thereof
  • Dexibuprofen microemulsion gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 0.6 g of polyethylene glycol 12 hydroxystearate and 0.3 g of glycerin, mix them evenly, add them to 0.6 g of ethyl oleate, stir to mix evenly, and obtain a mixed solution. Get dextroibuprofen 0.5g and add in the above-mentioned mixed solution, stir to dissolve, add dropwise water 8.5g under stirring, stir for a while to obtain the dextrobuprofen microemulsion. Take 0.5 g of carbomer and slowly add it to the dextroibuprofen microemulsion in a stirring state. After the addition is completed, place it at room temperature for 24 hours to fully swell the carbomer to obtain the dextroibuprofen microemulsion gel.

Embodiment 2

[0022] Take 2.14 g of polyethylene glycol 12 hydroxystearate and 2.14 g of glycerin, mix them uniformly, add them into 2.86 g of ethyl oleate, stir and mix evenly to obtain a mixed solution. Get dextrobuprofen 2.0g and add in the above-mentioned mixed solution, stir to dissolve, add dropwise 2.86g of water under stirring, stir for a while to obtain the dextrobuprofen microemulsion. Take 0.3 g of carbomer and slowly add it to the dextroibuprofen microemulsion in a stirring state, after adding, place it at room temperature for 24 hours to fully swell the carbomer to obtain the dextroibuprofen microemulsion gel.

Embodiment 3

[0024] Take 803.25g of Tween and 3.25g of diethylene glycol monoethyl ether, mix them uniformly, add them to 1.61g of ethyl oleate, stir and mix evenly to obtain a mixed solution. Get dextroibuprofen 0.5g and add in the above-mentioned mixed solution, stir to dissolve, add dropwise water 1.94g under stirring, stir for a while to obtain the dextrobuprofen microemulsion. Take 0.3 g of carbomer and slowly add it to the dextroibuprofen microemulsion in a stirring state, after adding, place it at room temperature for 24 hours to fully swell the carbomer to obtain the dextroibuprofen microemulsion gel.

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Abstract

The invention relates to dexibuprofen microemulsion gel and a preparation method thereof. The dexibuprofen microemulsion gel comprises components including dexibuprofen, a surfactant, a cosurfactant, an oil phase, carbomer and water. The dexibuprofen microemulsion gel is subjected to colon-drip delivery, the drug takes a microemulsion as a supporter, the drug solubility is increased, besides, the dexibuprofen microemulsion gel has proper flexibility and biological adhesion, a patient has a week foreign body sensation, the gel cannot flow out of the rectum easily after delivery, and absorption of the drug is facilitated, so that the better efficacy is guaranteed.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a Dexibuprofen microemulsion gel and a preparation method thereof. Background technique [0002] Ibuprofen is a non-steroidal anti-inflammatory drug, clinically used for the long-term treatment of rheumatoid arthritis and osteoarthritis, and also for the treatment of fever, various moderate pain and inflammation. Ibuprofen is composed of equal amounts of dextro-ibuprofen and levo-ibuprofen. Recent studies on pharmacological effects have shown that part of the L-body is converted into a dextro-body in the body to exert pharmacological effects, and the untransformed part of the L-body will cause comparison. Severe gastrointestinal reactions, long-term use may cause gastrointestinal bleeding. Dexibuprofen is the S-(+)-isomer of the racemate of ibuprofen, and its pharmacological activity is significantly higher than that of the racemate and Levorotatory, 150mg and 300mg dextroibupr...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/192A61K47/34A61P29/00
Inventor 李海刚
Owner 山东仁瑞生物科技有限公司
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