Pharmaceutical composition of dexibuprofen and medicinal use thereof

A technology of dexbuprofen and a composition, which is applied in directions such as drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems such as the related reports of dexbuprofen glomerulonephritis that have not yet been seen, and achieve treatment The effect of increasing the effect

Inactive Publication Date: 2016-10-12
王昌荣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between Dexibuprofen and its pharmaceutical composition and the treatment of glomerulonephritis

Method used

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  • Pharmaceutical composition of dexibuprofen and medicinal use thereof
  • Pharmaceutical composition of dexibuprofen and medicinal use thereof
  • Pharmaceutical composition of dexibuprofen and medicinal use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0019] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0020] Separation method: (a) Pulverize Qinpi (2kg), extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and successively use petroleum ether (3L×3 times) , ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) Use D101 macroporous resin to remove impurities from the n-butanol extract, first elute with 10% ethanol for 8 column volumes, then use 70% ethanol for 10 column volumes, collect 70% eluate, and concentrate u...

Embodiment 2

[0024] Embodiment 2: pharmacological action

[0025] In this example, a rat model of membranous glomerulonephritis induced by cationized bovine serum albumin (C-BSA) was used to observe the effect of drugs on improving the renal function of rats with membranous glomerulonephritis.

[0026] 1. Materials and methods

[0027] 1.1 Animals

[0028] SD rats were provided by the Animal Center of Guangzhou University of Traditional Chinese Medicine. NIH mice were provided by the Experimental Animal Center of Guangdong Health Department.

[0029] 1.2 Reagents and samples

[0030] Dexibuprofen was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Tripterygium wilfordii polyglycoside tablets: product of Shanghai Medical University Hongqi Pharmaceutical Factory; bovine serum albumin (BSA) from Beijing Tianxiangren Bioengineering Co., Ltd. Anhydrous ethylenedi...

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PUM

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Abstract

The invention discloses a pharmaceutical composition of dexibuprofen and its medical use. The pharmaceutical composition of dexibuprofen provided by the invention contains dexibuprofen and a natural product compound (I) with a novel structure. When dexibuprofen and compound (I) act alone, they have a therapeutic effect on glomerulonephritis; when dexibuprofen and compound (I) act in combination, the therapeutic effect is further improved, and can be developed into a drug for treating glomerulonephritis , compared with the prior art, has outstanding substantive features and remarkable progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of Dexibuprofen, in particular to a pharmaceutical composition of Dexibuprofen and its medical application. Background technique [0002] Dexibuprofen is a non-steroidal antipyretic and analgesic drug. It is mainly used for the treatment of acute upper respiratory tract infection in children, acute pharyngitis and other diseases, as well as acute mild to moderate pain. It has excellent curative effect and less side effects. [0003] So far, there is no report on the correlation between dexibuprofen and its pharmaceutical composition and the treatment of glomerulonephritis. Contents of the invention [0004] The purpose of the present invention is to provide a pharmaceutical composition of Dexibuprofen, which contains Dexibuprofen and a natural product, and Dexibuprofen and the natural product can synergistically treat glomerulonephritis. [0005] Above-mentioned purpo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/22A61K31/192A61K31/352A61P13/12
CPCC07D493/22A61K31/192A61K31/352
Inventor 王昌荣
Owner 王昌荣
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