288results about How to "Good redispersibility" patented technology

The invention discloses nanometer medicament microspheres. The microspheres comprise a medicament, nanoparticles, a polymer and medicinal auxiliary materials. The invention further provides a preparation method of the nanometer medicament microspheres. The method comprises the following steps of: preparing a medicament and medicinal auxiliary materials into a nanometer medicament; adding the nanometer medicament into a polymer-containing organic solvent mixed solution for emulsifying; adding a nanometer medicament-in-oil mixed suspension into a water mixed suspension containing nanoparticles or containing nanoparticles and a surfactant for emulsifying to obtain an oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil compound emulsion; and curing the obtained compound emulsion, and centrifugally collecting microspheres, wherein the obtained microspheres comprise the medicament, nanoparticles, the polymer and the medicinal auxiliary materials. An appropriate polymer material and an appropriate microsphere preparation method are selected, the prepared microspheres have high envelop rate, and a layer of self-assembled nanoparticles on the surfaces of the microspheres has the effects of improving cell adhesion and reducing inflammation and microencapsulation caused by local excessive acid and hydrophobic materials. The method disclosed by the invention can be applied to preparation of other medicament slow release or controlled release microspheres.

In order to provide a dispersion wherein the dispersed state of a fluorine-based resin is uniformly controlled, a polyimide precursor solution composition using this dispersion, an adhesive composition, a polyimide and polyimide film obtained from this polyimide precursor solution composition and having excellent heat resistance, excellent mechanical characteristics, excellent electrical characteristics such as lower dielectric constant and lower dielectric loss tangent, and excellent processability, a method for producing the polyimide, a method for producing the polyimide film, and a circuit board and coverlay film using the polyimide film, the present invention provides: a polyimide precursor solution composition containing a fluorine-based resin, which is characterized by containing a polyimide precursor solution and a nonaqueous dispersion of a fluorine-based resin containing a micropowder of a fluorine-based resin and a butyral resin or a fluorine-based additive containing at least a fluorine-containing group and a lipophilic group; and an adhesive composition.

An ultraviolet-curable white ink composition for ink jet recording is provided which has good dispersibility and good redispersibility and has excellent ejection stability, and provides excellent visibility of printed matter having a base material which forms a black or dark background. In an ultraviolet-curable ink composition for ink jet recording comprising titanium oxide, a polymeric dispersant having a basic functional group, a photopolymerizable compound and a photopolymerization initiator, the titanium oxide is surface-treated with silica and alumina and the weight of the silica, which coexists with the titanium oxide, is larger than that of the alumina.

The invention discloses an acrylic ester polymer emulsion and a preparation method thereof. The acrylic ester polymer emulsion comprises alkyl acrylate, alkyl methacrylate, hydroxy-alkyl ester, initiator, emulsifier and water, and alkyl carboxylic acid is prepared by emulsion polymerization. The preparation method comprises the following steps: mixing 30%-60% of the alkyl methacrylate, 50%-90% of the alkyl acrylate, 0-40% of the hydroxy-alkyl ester, 0-50% of the alkyl carboxylic acid to prepare a mixed monomer I; and then mixing rest of the alkyl methacrylate, the alkyl acrylate, the hydroxy-alkyl ester and the alkyl carboxylic acid to prepare a mixed monomer II; dropwise adding the mixed monomer II to rest of the mixed monomer I, and finally adding to a seed solution all together. Phase separation does not happen to the emulsion and emulsion powder prepared by using the same in film formation after redispersion, therefore, the emulsion and the emulsion powder prepared by using the same have good film formation and can meet all high-performance paintings on the film formation of emulsion.

An aqueous solution containing a polymer dispersant and a metal compound, and an aqueous solution of a reducing agent, are joined together and uniformly mixed while being subjected to reduction reaction to give metal microparticles, in a thin film fluid formed between processing surfaces arranged to be opposite to each other so as to be able to approach to and separate from each other, at least one of which rotates relative to the other, by using a reaction apparatus of uniform stirring and mixing the above aqueous solutions.

A water redispersible polymer powder is produced by drying an aqueous mixture of a water insoluble film-forming polymer and a colloidal stabilizer which includes a chelating agent and at least one water soluble polymer. The amount of chelating agent is at least 0.1% by weight, based upon the weight of the water insoluble film-forming polymer, and the amount of the at least one water soluble polymer is at least 0.1% by weight, based upon the weight of the water insoluble film-forming polymer. Dispersions or polymer compositions containing a chelating agent and water soluble polymer as a colloidal stabilizer exhibit an unexpectedly low viscosity which facilitates spray drying and permits use of high solids content dispersions with low pressure spray drying to increase production efficiency. The colloidal stabilizer composition provides unexpectedly superior redispersibility for water insoluble film-forming polymers having very low carboxylation levels.

To provide a photocurable liquid developer including colored resin particles, and an electrically insulating liquid that cures by light, wherein the electrically insulating liquid contains an unsaturated group-containing silicone compound represented by General Formula (1) below,

A high-molecular mPEG-PLGA-mPEG (PELGE) used as the axcessory of injection, oral-applied medicine, and the water-soluble medicine or the medicine difficult to dissolve in water is an amphipathic three-block copolymer, which is prepared from stannous octoate as catalyst, diisocyanate as coupling agent, polyethene glycol with single terminated end, glycollide, and lactide or polylactic acid-glycollic acid copolymer.

An ink composition for an inkjet including titanium dioxide having an average primary particle diameter of 200 nm or more; a water-soluble resin; self-dispersing resin particles having an average particle diameter of 40 nm or less; and water.

The invention discloses a method for preparing microspheres by using oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil. The method comprises the following steps of: preparing a medicament and medicinal auxiliary materials into a nanometer medicament; adding the nanometer medicament into a polymer-containing organic solvent mixed solution for emulsifying; adding a nanometer medicament-in-oil mixed suspension into a water mixed suspension containing nanoparticles or containing nanoparticles and a surfactant for emulsifying to obtain an oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil compound emulsion; and curing the obtained compound emulsion, and centrifugally collecting microspheres, wherein the obtained microspheres comprise the medicament, nanoparticles, the polymer and the medicinal auxiliary materials. An appropriate polymer material and an appropriate microsphere preparation method are selected, the prepared microspheres have high envelop rate, and a layer of self-assembled nanoparticles on the surfaces of the microspheres has the effects of improving cell adhesion and reducing inflammation and microencapsulation caused by local excessive acid and hydrophobic materials. The method disclosed by the invention can be applied to preparation of other medicament slow release or controlled release microspheres.

The invention relates to itraconazole composite powder and a preparation method thereof. The method comprises the following steps: dissolving itraconazole medicine into an organic solvent; adding the mixture of the itraconazole medicine and the organic solvent into a water solution with hydrophilic accessory ingredients for in-situ precipitation to separate out medicine; obtaining the nanometer amorphous itraconazole medicine grain turbid liquor; carrying out spraying drying or freeze drying on the obtained itraconazole medicine turbid liquor to obtain micron level itraconazole high molecular accessory ingredient composite powder; and then, dispersing the powder into water to obtain the uniform nanometer amorphous itraconazole medicine grain turbid liquor. The itraconazole high molecular accessory ingredient composite powder has good water-solubility and high dissolution speed, in addition, the operation is simple, the amplification is easy, the production cost is low, and the invention lays the foundation for the industrial production of the itraconazole medicine and the development and the utilization of novel preparations of the itraconazole medicine.

An aqueous suspension containing loteprednol etabonate wherein sedimented particles are detached easily from the container and adhesion of sedimented particles to the container and block formation are inhibited so that redispersion has been improved is provided. A method for improving redispersibility of loteprednol etabonate contained in the aqueous suspension is also provided.

A loteprednol etabonate-containing aqueous suspension comprising loteprednol etabonate and at least one compound selected from the group consisting of sorbic acid, salts thereof, and p-hydroxybenzoate esters, and a non-ionic surfactant is prepared.

The invention provides an image forming method having at least: applying, onto a recording medium, an ink composition containing at least a water-soluble organic solvent, a pigment, a polymer particle and water; and removing at least a part of the water-soluble organic solvent from the ink composition on the recording medium. The water-soluble organic solvent contains at least a water-soluble organic solvent having a vapor pressure of less than 10 Pa at 20° C., a boiling temperature of less than 260° C., and an SP value of less than 25, at a content of 30 mass % or more with respect to the total water-soluble organic solvent content of the ink composition.

The invention discloses medicament carrying polymer nano particles and a preparation method thereof in the technical field of pharmacy. The medicament carrying polymer nano particles contain medicaments and polylactic acid-methoxy polyethylene glycol (PLA-mPEG) or poly (lactic-co-glycolic acid)-methoxy polyethylene glycol (PLGA-mPEG). The molecular weight of the block polylactic acid (PLA) or the poly (lactic-co-glycolic acid) (PLGA) is 10,000 to 60,000, the molecular weight of the block methoxy polyethylene glycol (mPEG) is 2,000 to 5,000, and the block ratio of the PLA or the PLGA to the mPEG is (60:40)-(90:10). The preparation method of the nano particles avoids the defects of low medicament nano particle entrapment rate and serious burst release caused by using the conventional surfactant, complex removing steps and the like; and the medicament carrying polymer nano particles with high quality are synthesized by simplified processes and with relatively low cost.

The invention discloses a redispersable acrylic ester polymer emulsion powder and a preparation method thereof. The preparation method comprises the following steps: adding 1-5 parts by mass of pH regulator to 70-80 parts by mass of acrylic ester polymer emulsion, stirring evenly and regulating the pH value to be 7-10; adding 15-30 parts by mass of drying aid, and stirring evenly to obtain spray drying emulsion; setting the drying inlet temperature and the drying outlet temperature of a spray dryer respectively to be 110-150 DEG C and 60-80 DEG C, and setting the feeding speed to be 20-60 rpm and the rotating speed of a pulverizer to be 200-400 rpm; starting up a feeding system; drying the drying emulsion, and then collecting powder; and filtering to obtain the redispersable acrylic ester polymer emulsion powder. The glass transition temperature of a polymer which is contained in the acrylic ester polymer emulsion and forms a colloidal particle and the distribution of a carboxyl functional group of the polymer are in progressive change from the center of the colloidal particle to the surface. The emulsion powder obtained by the preparation method has good redispersion stability, film formation and water resistance.

A water redispersible polymer powder may be produced by drying an aqueous mixture of a water insoluble film-forming polymer and a colloidal stabilizer comprising a chelating agent to obtain a water redispersible polymer powder, where the amount of chelating agent is at least 0.1% by weight, preferably at least 1% by weight, most preferably at least 3% by weight, based upon the weight of the water insoluble film-forming polymer. Dispersions or polymer compositions containing a chelating agent as a colloidal stabilizer exhibit an unexpectedly low viscosity which facilitates spray drying and permits use of high solids content dispersions with low pressure spray drying to increase production efficiency. The chelating agents are stable at high pH and so high pH spray dryable compositions containing them as a colloidal stabilizer may sit or be stored for prolonged periods of time prior to spray drying without loss of effectiveness of the colloidal stabilizer.

A method of separating biologically ingestible microparticles is used to obtain biologically ingestible microparticles in a thin film fluid formed between two processing surfaces provided with a solution containing a first solvent in which an objective substance to be pulverized is dissolved and a solvent capable of serving as a second solvent in which the solubility of the microparticles is lower than in the first solvent, the two processing surfaces being arranged so as to be able to approach to and separate from each other, at least one of which rotates relative to the other.

In the method for producing biologically ingestible microparticles by separating raw materials of biologically ingestible microparticles by a neutralization reaction in a fluid, the fluid is formed into a thin film fluid between two processing surfaces arranged so as to be able to approach to and separate from each other, at least one of which rotates relative to the other, and biologically ingestible microparticles are separated by a neutralization reaction in the thin film fluid.

A solution containing a first solvent in which a chemical as a main eye drop component is dissolved, and a solvent capable of serving as a second solvent in which the solubility of the chemical is lower than in the first solvent, are mixed in a thin film fluid formed between two processing surfaces arranged so as to be able to approach to and separate from each other, at least one of which rotates relative to the other, thereby separating drug particles and providing suspended eye drops based on the drug particles.

The invention relates to a preparation method of redispersible latex powder, which comprises the following steps: (1) preparing a cation emulsion; (2) adding an inorganic substance precursor into the cation emulsion for a sol-gel reaction so as to prepare a composite emulsion with an inorganically-coated polymer core shell particle structure; (3) performing spray drying of the composite emulsion to obtain the latex powder. The inorganic coating external layer of particles in the composite emulsion has a high melting point or softening point, can prevent contact and fusion of internal particle polymer cores of the redispersible latex powder during the high temperature spray drying process, and prevent adhesion and caking between the redispersible latex powder, and adherence to the inner wall of the spray drying device. The dried redispersible latex powder has excellent fluidity, redispersibility, and redispersion colloid stability of corresponding aqueous dispersion.