74results about How to "Particle regularity" patented technology

The invention discloses nanometer medicament microspheres. The microspheres comprise a medicament, nanoparticles, a polymer and medicinal auxiliary materials. The invention further provides a preparation method of the nanometer medicament microspheres. The method comprises the following steps of: preparing a medicament and medicinal auxiliary materials into a nanometer medicament; adding the nanometer medicament into a polymer-containing organic solvent mixed solution for emulsifying; adding a nanometer medicament-in-oil mixed suspension into a water mixed suspension containing nanoparticles or containing nanoparticles and a surfactant for emulsifying to obtain an oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil compound emulsion; and curing the obtained compound emulsion, and centrifugally collecting microspheres, wherein the obtained microspheres comprise the medicament, nanoparticles, the polymer and the medicinal auxiliary materials. An appropriate polymer material and an appropriate microsphere preparation method are selected, the prepared microspheres have high envelop rate, and a layer of self-assembled nanoparticles on the surfaces of the microspheres has the effects of improving cell adhesion and reducing inflammation and microencapsulation caused by local excessive acid and hydrophobic materials. The method disclosed by the invention can be applied to preparation of other medicament slow release or controlled release microspheres.

The invention relates to a method for preparing microspheres by water-in-oil-in-oil-in-water in the technical field of pharmacy, which comprises the following steps: a medicine solution is prepared first, and is dispersed into an organic solution with a slow release or controlled release functional material, and the stirring or swirling and so on is preformed to make the medicine solution dispersed evenly to form a suspension; then the suspension is added into an external oil phase to be stirred or swirled to form microspheres, and finally the microspheres are transferred into a large water phase for solidification; and then the microspheres are centrifugally collected, freeze-dried and preserved, wherein in the obtained microspheres, the medicine accounts for 0.01 to 50 percent of the weight of the entire microshperes, the slow release or controlled release material accounts for 20 to 99.99 percent of the weight of the entire microshperes, and an auxiliary material accounts for 0 to 30 percent of the weight of the entire microshperes. The microspheres prepared by the method have smooth and round surfaces and good uniformity, are regular, have no adhesion, and have adjustable grain diameters; the used organic solvent is environment-friendly, is easy to remove by water, and does not affect the treatment effect of the medicine; and the microspheres have high envelope rate, and small burst release and incomplete release.

The invention provides a preparation method of extinction polyvinyl chloride resin. The preparation method comprises the following steps: acquiring vinyl chloride monomer, deionized water, an initiator, a buffering agent, a dispersant and a matting agent which serve as reaction raw materials; performing pre-emulsification treatment on the matting agent by use of part of the dispersant; adding the vinyl chloride monomer, the deionized water, the initiator, the buffering agent and the rest dispersant into a polymerization kettle, performing polyreaction, and adding the matting agent subjected to pre-emulsification treatment during the reaction process so as to prepare the extinction polyvinyl chloride resin, wherein the matting agent is a monomer or polymer containing two or more reaction active functional groups, the dosage of the deionized water accounts for 105-200% of the weight of the vinyl chloride monomer, the dosage of the initiator accounts of 0.04-0.18% of the weight of the vinyl chloride monomer, the total dosage of the dispersant accounts for 0.04-0.15% of the weight of the vinyl chloride monomer, the dosage of the buffering agent accounts for 0.06-0.18% of the weight of the vinyl chloride monomer, and the dosage of the matting agent accounts for 0.01-8.0% of the weight of the vinyl chloride monomer. The prepared extinction polyvinyl chloride resin is fewer in crystal spot and good in extinction effect.

The invention discloses a synthesis method of macromolecule water-absorbent resin for physiological hygiene. The macromolecule water-absorbent resin is formed by polymerization of multiple unsaturated double-bond monomers, and achieves polymerization of multiple monomers in a mode of aqueous solution free radical polymerization by adopting a three-section composite initiating system, thereby preparing the high-water-absorbent resin which is regular in granularity, uniform in crosslink, and has few residual monomer content; the high-water-absorbent resin is subjected to surface treatment by utilizing surface treatment liquid, reduces the residual monomer content further, and forms gradient crosslink on the surface of the high-water-absorbent resin, thereby preparing the ultra-high-water-absorbent resin finally. The water absorbent has excellent performances of particles with white appearance, good fluidity, pressure resistance, salt resistance, rapid liquid absorption speed, good surface liquid transmission performance, high liquid absorption amount, less residual monomer content, dry and comfortable surface after water absorption and the like, and is a physiological hygiene product in the field of physiological hygiene, and especially has high requirements on liquid absorption speed and liquid absorption amount of infant paper diapers, adult incontinence sheets, woman sanitary towels and the like.

The invention discloses a method for preparing microspheres by using oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil. The method comprises the following steps of: preparing a medicament and medicinal auxiliary materials into a nanometer medicament; adding the nanometer medicament into a polymer-containing organic solvent mixed solution for emulsifying; adding a nanometer medicament-in-oil mixed suspension into a water mixed suspension containing nanoparticles or containing nanoparticles and a surfactant for emulsifying to obtain an oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil compound emulsion; and curing the obtained compound emulsion, and centrifugally collecting microspheres, wherein the obtained microspheres comprise the medicament, nanoparticles, the polymer and the medicinal auxiliary materials. An appropriate polymer material and an appropriate microsphere preparation method are selected, the prepared microspheres have high envelop rate, and a layer of self-assembled nanoparticles on the surfaces of the microspheres has the effects of improving cell adhesion and reducing inflammation and microencapsulation caused by local excessive acid and hydrophobic materials. The method disclosed by the invention can be applied to preparation of other medicament slow release or controlled release microspheres.

The invention discloses medicament carrying polymer nano particles and a preparation method thereof in the technical field of pharmacy. The medicament carrying polymer nano particles contain medicaments and polylactic acid-methoxy polyethylene glycol (PLA-mPEG) or poly (lactic-co-glycolic acid)-methoxy polyethylene glycol (PLGA-mPEG). The molecular weight of the block polylactic acid (PLA) or the poly (lactic-co-glycolic acid) (PLGA) is 10,000 to 60,000, the molecular weight of the block methoxy polyethylene glycol (mPEG) is 2,000 to 5,000, and the block ratio of the PLA or the PLGA to the mPEG is (60:40)-(90:10). The preparation method of the nano particles avoids the defects of low medicament nano particle entrapment rate and serious burst release caused by using the conventional surfactant, complex removing steps and the like; and the medicament carrying polymer nano particles with high quality are synthesized by simplified processes and with relatively low cost.

This invention relates to components and preparation method for a composite carrier catalyst for ethylene homopolymerization or copolymerization with other alpha-olefins. The catalyst comprises at least one Mg composite, at least one Ti compound, at least one organic alcohol compound, at least one Si compound, and at least one inorganic inert carrier. The Mg composite is prepared by dissolving Mg compound in organic epoxy compound and organic phosphorus compound system. The catalyst has such advantages as high catalytic activity, high hydrogen sensitivity and narrow particle size distribution of polymer. The catalyst is suitable for slurry polymerization of ethylene, combined polymerization process where catalyst with high activity and good particle morphology is needed, and gas phase fluidized bed process.

The present application discloses rumex hanus vegetable protein artificial nutrition rice. The rumex hanus vegetable protein artificial nutrition rice comprises rumex hanus powder or raw rumex hanus pulp, corn flour, tapioca flour, millet flour or rice flour, sorghum rice flour, mung bean flour and purified water. By increasing the rumex hanus powder or raw rumex hanus pulp, the artificial nutrition rice is more abundant in nutrition, ensures inherent fat, carbohydrates and dietary fibers of food, increases human body needed proteins, amino acids, chlorogenic acid, beta-carotene, vitamins, rheum emodin, calcium, selenium, potassium, iron and other trace elements, has characteristics of being fine in quality, tough and good in taste, increasing appetite, being easy for absorption, etc., andis free of any additives and good for people's health .

The invention discloses a PVC resin with ultra-low degree of polymerization and a manufacturing method thereof. In the invention, a polymerization method is adopted to carry out polymerization reaction, the reaction temperature is 60-64 DEG C, and the reaction pressure is less than 1.0 MPa; a first chain transfer agent is added when the polymerization reaction is carried out for 0-30min, and then0.005-0.012% of vinyl chloride monomer (VCM) is added; a second chain transfer agent is added when the polymerization reaction is carried out for 60-90min, and then 0.005-0.02% of monomer is added toobtain the PVC resin with ultra-low degree of polymerization. The PVC resin manufactured by the invention has the advantages of the average degree of polymerization below 500, high apparent density, low melting and gelatinization temperature, low melt viscosity, good transparency, short plasticization time and favorable processability and the like, and the phenomenon of accelerating products agingdue to the transfer of plasticizer does not appear in machining process.

This method provides a preparation method for lithium manganate powder which is used as anode material of lithium ion cell. This method includes: first, use a water soluble macromolecule polymer as dispersant/gelatinizer to prepare 0.2~20g/100ml concentration aqueous solution which is used as solvent in the next step; then add water soluble lithium ion compound to the solvent to acquire 0.05~2 mol/L lithium-concentration lithium solution; next, add solid MnO2 powder in mol ratio of (0.8~1.2) ~2 into the obtained lithium solution agitating meanwhile, then evaporate water to get gelinite, in the end, roast the gelinite under 300~850 deg.C for 0.7~28 hours. Advantages: homogeneous grains, high first-charge-discharge efficiency, high reversible-ratio capacity and excellent cycle performance.

The present invention discloses a silurus asotus feed phagostimulant and a preparation method thereof, and belongs to the technical field of feed additive preparations. Based on nutritional requirements of silurus asotus and water body environment, and combining food intake characteristics, a formula of raw materials is optimized. The silurus asotus feed phagostimulant scientifically combines compound flavor peptides greatly improving palatability and feed utilization rate, having a relatively strong anti-oxidation effect and eliminating free radicals; an accharomyces cerevisiae culture having functional characteristics of being strong in nutrition, biological activity, oxidation resistance, etc.; a high-calcium cerasus humilis extract effectively supplementing calcium, iron and soluble fibers, having a strong embedding effect and prolonging a shelf life; artemisia carvifolia seed powder significantly improving antifreeze effects and stability, improving water resistance and gloss, and enhancing and promoting palatability; and wheat malt powder providing rich nutrients, bioactive substances and plant enzyme sources. Finally, the prepared silurus asotus feed phagostimulant is strong in phagostimulant and good in production performances.

The invention discloses growth hormone-containing nanometer medicament microspheres. The microspheres comprise a medicament, nanoparticles, a polymer and medicinal auxiliary materials. The invention further provides a preparation method of the microspheres. The method comprises the following steps of: preparing growth hormone and medicinal auxiliary materials into a nanometer medicament; adding the nanometer medicament into a polymer-containing organic solvent mixed solution for emulsifying; adding a nanometer medicament-in-oil mixed suspension into a water mixed suspension containing nanoparticles or containing nanoparticles and a surfactant for emulsifying to obtain an oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil compound emulsion; and curing the obtained compound emulsion, and centrifugally collecting microspheres, wherein the obtained microspheres comprise the medicament, nanoparticles, the polymer and the medicinal auxiliary materials. An appropriate polymer material and an appropriate microsphere preparation method are selected, the prepared microspheres have high envelop rate, and a layer of self-assembled nanoparticles on the surfaces of the microspheres has the effects of improving cell adhesion and reducing inflammation and microencapsulation caused by local excessive acid and hydrophobic materials. The method disclosed by the invention can be applied to preparation of other medicament slow release or controlled release microspheres.

The invention discloses a method for preparing polyvinyl chloride resin. The method is characterized by comprising the following steps: adding water, a vinyl chloride monomer, a composite dispersion system, a porosity adjusting agent, a chain transferring agent, a pH value buffer agent and an initiator into a polymerization kettle, performing a polymerization reaction kettle in the polymerization reaction kettle with a stirring device at the pressure of 1.00-1.20MPa, adding a reaction terminator, discharging out a residual vinyl chloride monomer, and collecting a target product from a reaction product, wherein the composite dispersion system is a mixture of polyvinyl alcohol and hydroxypropyl methyl cellulose which are subjected to partial alcoholysis. The polyvinyl chloride resin prepared by using the method disclosed by the invention is high in porosity, slight in fisheye, low in surface cover rate, tidy in granule morphology, concentrated in resin particle size distribution and easy in residual monomer desorption.

The invention relates to the technical field of rice processing, particularly to a polished rice processing method with the rice embryo content more than 80%. The method comprises steps as follows: winnowing, impurity removal, dust removal, primary magnetic separation, primary stone removal, husking, rice bran separation, secondary stone removal, secondary magnetic separation, coarse grinding, fine grinding, classification, polishing, wind screening, color sorting and packaging. Proper embryo pulp or mixed pulp is sprayed on surfaces of rice grains repeatedly, so that nutrient elements in the rice are difficult to remove during processing, on the contrary, the content of the nutrient elements in the rice is increased, the nutrient structure and the taste of the rice are improved, all nutritive indexes meet requirements of the Food Hygiene Law, the rice embryo content of the processed rice is more than 80%, the polished rice degree is more than 95%, and the broken rice content does not exceed 5%.

The invention discloses a preparation method of highly polymerized polyvinyl chloride resin chain extender emulsion. According to the method, two emulsifiers with different hydrophile-lipophile balance (HLB) values are compounded as the emulsifier of the chain extender. The method comprises the following concrete processes: by using a product in span series or a product in Tween series as emulsifier materials of the chain extender, taking two materials and the chain extender according to the accumulated dosage to be put into a reaction kettle, mixing, controlling the stirring time and the stirring speed, and evenly stirring, so as to respectively prepare acrylic ester chain extender emulsion and allyl ester chain extender emulsion; and finally compounding according to the mass ratio of 7 to 3, and evenly mixing, so as to obtain the highly polymerized polyvinyl chloride resin chain extender emulsion. The chain extender emulsion prepared by the method is applied to a polyvinyl chloride (PVC) resin polymerization reaction system; the mean polymerization degree of the prepared PVC resin is obviously improved. The preparation method is suitable for preparation of functional additive emulsion such as a polymer polymerization chain extender.

The invention discloses compound zinc-iron calcium granule and a preparation method thereof. The compound zinc-iron calcium granule is prepared from the following raw materials in parts by weight: 20-50 parts of zinc gluconate, 1-5 parts of vitamin B2, 50-150 parts of ferrous gluconate, 300-600 parts of calcium gluconate, 1000-2000 parts of a filler, 3-6 parts of an adhesive, 3-6 parts of essence and 3-15 parts of ethyl alcohol. According to the preparation method, the vitamin B2 in the form of a vitamin B2 ethanol solution is mixed with the adhesive for pelletizing, so that the differential item of vitamin B2 is up to standard, and the quality of a finished product is ensured. Then one-step pelletizing is adopted to finish multi-step working procedures including mixing, pelletizing, drying and the like on one equipment, so that color change caused by solvent residue during the wet granulation process and pharmaceutical ingredient loss caused by heating during the drying process are avoided, and the problems that escaped dust is serious and cross contamination is easily caused in case of tabletting during the dry granulation process are also avoided.

The invention discloses a high-yield catfish feed attractant and a preparation method thereof and belongs to the technical field of feed additive preparation. The high-yield catfish feed attractant and the preparation method thereof have the advantages that the nutritional requirements of catfish and water environments are combined with the ingestion features of the catfish to optimize a raw material formula, raw materials are scientifically compounded to greatly increase palatability and feed utilization rate, and the attractant comprises compound flavor peptide which has high anti-oxidation effect and is capable of removing free radicals; the high-yield catfish feed attractant contains saccharomyces cerevisiae culture with functional features such as high nutrition, high bioactivity and high oxidation resistance, Prunus Humilis Bunge extract which can effectively supplement calcium, iron and soluble fibers, has a powerful embedding effect and can prolong shelf life, wormwood seed powder which can evidently increase an anti-freezing effect and stability, increase water resistance and glossiness, enhance and promote palatability and lower powder content, and wheat malt powder which can provide rich nutritional substances, bioactive substances, fragrant substances and plant enzyme sources; the prepared high-yield catfish feed attractant is high in palpability and good in production performance.

The invention discloses a high-digestion high-utilization-rate catfish feed, and belongs to the technical field of processing of catfish feeds. Based on nutritional requirements of catfish and water body environment, the digestion characteristics of the catfish are combined, the formula of a conventional catfish feed is optimized, and a feed complex enzyme, wormwood seed powder, a prunus humilis bunge extract and a phagostimulant are scientifically compounded, so that the catfish feed can be prepared, wherein the feed complex enzyme can effectively degrade anti-nutritional factors in the catfish feed, increase the utilization rate of nutrient substances of starch, protein, minerals and the like, increase the protein level, the organism antioxidative activity and the digestive absorption rate of the catfish, significantly increase the digestibility and the production properties of the catfish, reduce the feed coefficient, prevent the water bodies from being polluted and maintain good water quality is scientifically compounded; the wormwood seed powder can significantly improve the caking property, the water resistance, the glossiness and the frost resistance of the catfish feed and reduce the powder containing rate of the feed; the prunus humilis bunge extract can effectively complement calcium, ferrum and soluble fibers; the phagostimulant can substantially improve the palatability of the feed; and therefore, the catfish feed is good in feed coefficient, high in digestibility, good in production properties, high in propagation properties, high in disease resistance, high in palatability and low in cost.

The invention discloses a narrow molecular weight distribution chloroether resin and a preparation method thereof. The narrow molecular weight distribution chloroether resin comprises, by mass, 1.5-3parts of a dodecyl sodium salt, 2.5-7 pats of isobutyl vinyl ether, 0.4-0.9 parts of a persulfate, 2.5 parts of sodium dodecyl sulfate, 1.25-2.15 parts of a buffer agent, 65-80 parts of vinyl chlorideand 17.5-35 parts of isobutyl vinyl ether. The preparation method comprises: adding a part of isobutyl vinyl ether into a polymerization reactor, reducing a use amount of a buffer agent in the polymerization reactor to 0-1/3 the total use amount of the buffer agent and carrying out a reaction process under constant temperature and constant pressure control to obtain chloroether resin. The chloroether resin has narrow molecular weight distribution, contains regular particles and has a loose structure and good processing properties. The preparation method has the advantages of stable reaction,easy control, large polymerization rate, short reaction time and low raw material cost.

The invention belongs to the technical field of pet health-care products, and particularly relates to a stomach-invigorating and digestion-promoting tablet for pets and a preparation method thereof. The health-care food is prepared from the following components in percentage by mass: 1 to 10 percent of fructus crataegi, 1 to 10 percent of rhizoma dioscoreae, 1 to 10 percent of fructus hordei germinatus, 0.01 to 5 percent of selenium-enriched yeast, 0.01 to 5 percent of vitamin B complex, 0.01 to 5 percent of lipase, 0.01 to 5 percent of amylase, 0.01 to 5 percent of cellulase and the balance of auxiliary materials, and the total amount is 100 percent. According to the invention, hawthorn, Chinese yam, malt, selenium-enriched yeast, multivitamins, lipase, amylase and cellulase are used as active ingredients, the tablet has good prevention and improvement effects on gastrointestinal tracts of pets, the tablet prepared by the method has good food calling effect, the dosage of the raw materials and various auxiliary materials reaches the optimal proportion, and the product has strong stability and high absorption and utilization rate.