Method for preparing microspheres with solid-in-oil-in-hydrophilic oil-in-ethanol

Abstract

The invention relates to a method for preparing microspheres with solid-in-oil-in-hydrophilic oil-in-ethanol, belonging to the field of the pharmaceutical technology and comprising the following steps: (1) adding and stirring or swirling medicament particles to the organic solution, i.e. the oil phase of sustained-release or controlled-release material; (2) adding mixed suspension to another hydrophilic organic solution, i.e. hydrophilic oil phase and stirring the mixed suspension to the hydrophilic organic solution, i.e. the hydrophilic oil phase for 0.1-5 min to form spheres of 1-500 Mum; (3) transferring the mixed suspension containing the microspheres to ethanol and solidifying the mixed suspension for 1-4h; (4) and drying and freezing the sample to obtain the dry microspheres. The diameter of the microspheres can be controlled and adjusted from 1 Mum to 500 Mum according to the need; the microspheres can not cause pollution to the environment; the surfaces of the microspheres aresmooth and round; the microspheres are consistent without being adhered; the frozen-dried powder of the microspheres is white, fine and loose, can not collapse, can not be adhered and has good dispersity. The method can be used for preparing various sustained-release or controlled-release microspheres of various medicament or preparing the adjuvant of vaccines.

Description

technical field [0001] The invention relates to a preparation method in the field of pharmaceutical technology, in particular to a method for preparing hydrophilic oil-in-ethanol-oil-in-oil-oil-in-oil solid (S / O / hO / E) microspheres. Background technique [0002] In the pharmaceutical industry, from drug discovery to clinical application, the last link is drug preparation. Some of the drugs need long-term administration to be cured; others need targeted and other local administration. To achieve these goals, raw materials must be prepared into corresponding dosage forms. For example, drugs that require long-term administration but have a short half-life in the body should be prepared as sustained-release dosage forms; for the treatment of some tumors, some drugs need to be targeted to the disease, such as embolization microsphere preparations that target tumor blood vessels; Since recombinant technology has been used in the expression and production of therapeutic proteins f...

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